Human Pathology
Volume 34, Issue 1 , Pages 32-40 , January 2003

Cell kinetics and genetic instabilities in differentiated type early gastric cancers with different mucin phenotype

,Accepted 17 September 2002.

References 

  1. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 1965;64:31–49
  2. Nakamura K, Sugano H, Takagi K. Carcinoma of the stomach in incipient phase: Its histogenesis and histological appearances. Jpn J Cancer Res. 1968;59:251–258
  3. Endoh Y, Tamura G, Motoyama T, et al.  Well-differentiated adenocarcinoma mimicking complete-type intestinal metaplasia in the stomach. Hum Pathol. 1999;30:826–832
  4. Sasaki I, Yao T, Nawata H, et al.  Minute gastric carcinoma of differentiated type with special reference to the significance of intestinal metaplasia, proliferative zone, and p53 protein during tumor development. Cancer. 1999;85:1719–1729
  5. Tatematsu M, Ichinose M, Miki K, et al.  Gastric and intestinal phenotypic expression of human stomach cancers as revealed by pepsinogen immunohistochemistry and mucin histochemistry. Acta Pathol Jpn. 1990;40:494–504
  6. Tajima Y, Shimoda T, Nakanishi Y, et al.  Gastric and intestinal phenotypic marker expression in gastric carcinomas and its prognostic significance: Immunohistochemical analysis of 136 lesions. Oncology. 2001;61:212–220
  7. Koseki K, Takizawa T, Koike M, et al.  Distinction of differentiated-type early gastric carcinoma with gastric type mucin expression. Cancer. 2000;89:724–732
  8. Kabashima A, Yao T, Sugimachi K, et al.  Relationship between biologic behavior and phenotypic expression in intramucosal gastric carcinomas. Hum Pathol. 2002;33:80–86
  9. Ohmura K, Tamura G, Endoh Y, et al.  Microsatellite alterations in differentiated-type adenocarcinomas and precancerous lesions of the stomach with special reference to cellular phenotype. Hum Pathol. 2000;31:1031–1035
  10. Endoh Y, Sakata K, Tamura G, et al.  Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways. J Pathol. 2000;191:257–263
  11. Loeb LA. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 1991;51:3075–3079
  12. Lee HS, Lee BL, Kim SH, et al.  Microsatellite instability in synchronous gastric carcinomas. Int J Cancer. 2001;91:619–624
  13. Tokunaga E, Oki E, Oda S, et al.  Frequency of microsatellite instability in breast cancer determined by high-resolution fluorescent microsatellite analysis. Oncology. 2000;59:44–49
  14. Oda S, Oki E, Maehara Y, et al.  Precise assessment of microsatellite instability using high-resolution fluorescent microsatellite analysis. Nucleic Acids Res. 1997;25:3415–3420
  15. Thibodeau SN, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. Science. 1993;260:816–819
  16. Lothe RA, Peltomaki P, Meling GI, et al.  Genomic instability in colorectal cancer: Relationship to clinicopathological variables and family history. Cancer Res. 1993;53:5849–5852
  17. Michael-Robinson JM, Biemer-Hüttmann AE, Purdie DM, et al.  Tumour-infiltrating lymphocytes and apoptosis are independent features in colorectal cancer stratified according to microsatellite instability status. Gut. 2001;48:360–366
  18. Michael-Robinson JM, Reid LE, Purdie DM, et al.  Proliferation, apoptosis, and survival in high-level microsatellite instability sporadic colorectal cancer. Clin Cancer Res. 2001;7:2347–2356
  19. Rugge M, Correa P, Dixon MF, et al.  Gastric dysplasia: The Padova international classification. Am J Surg Pathol. 2000;24:167–176
  20. Japanese Research Society for Gastric Cancer . The General Rules for Gastric Cancer Study. ed 12. Tokyo, Japan: , Kinbara; 1993;
  21. Katsuyama T, Spicer SS. Histochemical differentiation of complex carbohydrates with variants of the concanavarin A horseradish peroxidase method. J Histochem Cytochem. 1978;26:223–250
  22. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992;119:493–501
  23. Boland CR, Thibodeau SN, Hamilton SR, et al.  A national cancer institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of intestinal criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res. 1998;58:5248–5257
  24. Goessl C, Heicappell H, Münker R, et al.  Microsatellite analysis of plasma DNA from patients with clear cell renal carcinoma. Cancer Res. 1998;58:4728–4732
  25. Kobayashi K, Okamoto T, Takayama S, et al.  Genetic instability in intestinal metaplasia is a frequent event leading to well-differentiated early adenocarcinoma of the stomach. Eur J Cancer. 2000;36:1113–1119
  26. Wyllie AH. The biology of cell death in tumors. Anticancer Res. 1996;5:131–136
  27. Shinohara T, Ohshima K, Murayama H, et al.  Apoptosis and proliferation in gastric carcinoma: The association with histological type. Histopathology. 1996;29:123–129
  28. Ikeda M, Shomori K, Endo K, et al.  Frequent occurrence of apoptosis in an early event in the oncogenesis of human gastric carcinoma. Virchows Arch. 1998;432:43–47
  29. Tamura G, Sato K, Akiyama S, et al.  Molecular characterization of undifferentiated-type gastric carcinoma. Lab Invest. 2001;81:593–598
  30. Bonner RF, Emmert-Buck M, Cole K, et al.  Laser capture microdissection: Molecular analysis of tissue. Science. 1997;278:1481–1483
  31. Dillon D, Zheng K, Costa J. Rapid, efficient genotyping of clinical tumor samples by laser-capture microdissection/PCR/SSCP. Exp Mol Pathol. 2001;70:195–200
  32. Cawkwell L, Bell SM, Lewis FA, et al.  Rapid detection of allele loss in colorectal tumors using microsatellites and fluoresent DNA technology. Br J Cancer. 1993;67:1262–1267
  33. Cawkwell L, Li D, Lewis FA, et al.  Microsatellite instability in colorectal cancer: Improved assessment using fluorescent polymerase chain reaction. Gastroenterology. 1995;109:465–471
  34. Oki E, Oda S, Maehara Y, et al.  Mutated gene-specific phenotype of dinucleotide repeat instability in human colorectal carcinoma cells deficient in DNA mismatch repair. Oncogene. 1999;18:2143–2147
  35. Simms LA, Radford-Smith G, Biden KG, et al.  Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers. Oncogene. 1998;17:2003–2008
  36. Biden KG, Simms LA, Cummings M, et al.  Expression of Bcl-2 protein is decreased in colorectal adenocarcinomas with microsatellite instability. Oncogene. 1999;18:1245–1249
  37. Soong R, Robbins PD, Dix BR, et al.  Concordance between p53 protein overexpression and gene mutation in large series of common human carcinogenesis. Hum Pathol. 1996;27:1050–1055
  38. Keller G, Rudelius M, Vogelsang H, et al.  Microsatellite instability and loss of heterozygosity in gastric carcinoma in comparison to family history. Am J Pathol. 1998;152:1281–1289
  39. Rampino N, Yamamoto H, Ionov Y, et al.  Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science. 1997;275:967–969
  40. Markowitz S, Wang J, Myeroff L, et al.  Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science. 1995;268:1276–1277
  41. Wu MS, Lee CW, Shun CT, et al.  Clinicopathological significance of altered loci of replication error and microsatellite instability–associated mutations in gastric cancer. Cancer Res. 1998;58:1494–1497
  42. Oliveira C, Seruca R, Seixas M, et al.  The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different “target genes”: A study of the TGF-βRII, IGFII-R, and BAX genes. Am J Pathol. 1998;153:1211–1219

 Address correspondence and reprint requests to Jiro Watari, MD, Third Department of Internal Medicine, Asahikawa Medical College, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan.

PII: S0046-8177(02)29702-6

doi: 10.1053/hupa.2003.2

Human Pathology
Volume 34, Issue 1 , Pages 32-40 , January 2003