Human Pathology
Volume 34, Issue 1 , Pages 89-92 , January 2003

Two cases of unusual acral melanocytic tumors: Illustration of molecular cytogenetics as a diagnostic tool

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  1. Barnhill RL, Argenyi ZB, From L, et al.  Atypical Spitz nevi/tumors: Lack of consensus for diagnosis, discrimination from melanoma, and prediction of outcome. Hum Pathol. 1999;30:513–520
  2. Piepkorn M. On the nature of histologic observations: The case of the Spitz nevus. J Am Acad Dermatol. 1995;32:248–254
  3. Bastian BC, LeBoit PE, Hamm H, et al.  Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization. Cancer Res. 1998;58:2170–2175
  4. Bastian BC, Wesselmann U, Pinkel D, et al.  Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma. J Invest Dermatol. 1999;113:1065–1069
  5. Bastian BC, LeBoit PE, Pinkel D. genomic approaches to skin cancer diagnosis. Arch Dermatol. 2001;137:1507–1511
  6. Bastian BC, Kashani-Sabet M, Hamm H, et al.  Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin. Cancer Res. 2000;60:1968–1973
  7. Casso EM, Grin-Jorgensen CM, Grant-Kels JM. Spitz nevi. J Am Acad Dermatol. 1992;27:901–913
  8. Kukita A, Ishihara K. Clinical features and distribution of malignant melanoma and pigmented nevi on the soles of the feet in Japan. J Invest Dermatol. 1989;92:210S–213S
  9. Harvell JD, Bastian BC, LeBoit PE: Persistent and recurrent Spitz nevi: A histopathologic, immunohistochemical and molecular pathologic study of 22 cases. Am J Surg Pathol, in press
  10. Barnhill RL, Flotte TJ, Fleischli M, et al.  Cutaneous melanoma and atypical Spitz tumors in childhood. Cancer. 1995;76:1833–1845
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☆ Supported by the Marvin and Roma Auerback Melanoma Fund and a Grant-in Aid for Scientific Research (C2-12670812) from the Japan Society for the Promotion of Science.

☆☆ Address correspondence and reprint requests to Fumiaki Shirasaki, MD, PhD, Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8641, Japan.

PII: S0046-8177(03)00004-2

doi: 10.1053/hupa.2003.49

Human Pathology
Volume 34, Issue 1 , Pages 89-92 , January 2003

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