Recurrence of lymphangioleiomyomatosis after single lung transplantation: New insights into pathogenesis☆

Accepted 17 September 2002.

Abstract

Lymphangioleiomyomatosis (LAM) is a rare disease found primarily in white women of childbearing age. The present study describes a case of recurrent LAM after single lung transplantation. Double-staining nonisotopic in situ hybridization, immunohistochemistry, and short tandem repeat loci analysis demonstrated that the recurrent LAM lesions originated from the recipient. The data strongly support that metastatic spread of LAM cells or migration of progenitor cells plays an important role in the pathogenesis of LAM. HUM PATHOL 34:95-98. Copyright 2003, Elsevier Science (USA). All rights reserved.

Keywords: lung transplantation, lymphangioleiomyomatosis, recurrence, nonisotopic in situ hybridization, short-tandem repeat loci analysis

Abbreviations: IHC , immunohistochemistry, LAM , lymphangioleiomyomatosis, NISH , nonisotopic in situ hybridization, PCR , polymerase chain reaction, STR , short tandem repeat, TSC , tuberous sclerosis complex

Institute of Pathology and Institute of Forensic Medicine, Ludwig-Maximilians University, Munich, Germany

☆ Address correspondence and reprint requests to Iris Bittmann, MD, Institute of Pathology, Ludwig-Maximilians University, Thalkirchner Str. 36, 80337 Munich, Germany.

PII: S0046-8177(03)00005-4

doi:10.1053/hupa.2003.50

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