Human Pathology
Volume 34, Issue 1 , Pages 95-98 , January 2003

Recurrence of lymphangioleiomyomatosis after single lung transplantation: New insights into pathogenesis

,Accepted 17 September 2002.

References 

  1. Taylor JR, Ryu J, Colby TV, et al.  Lymphangioleiomyomatosis: Clinical course in 32 patients. N Engl J Med. 1990;323:1254–1260
  2. Strizheva GD, Carsillo T, Kruger WD, et al.  The spectrum of mutations in TSC1 and TSC2 in women with tuberous sclerosis and lymphangiomyomatosis. Am J Respir Crit Care Med. 2001;163:253–258
  3. Bittmann I, Dose TB, Muller C, et al.  Lymphangioleiomyomatosis: Recurrence after single lung transplantation. Hum Pathol. 1997;28:1420–1423
  4. Carsillo T, Astrinidis A, Henske EP. Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Proc Natl Acad Sci U S A. 2000;97:6085–6090
  5. Tanaka H, Imada A, Morikawa T, et al.  Diagnosis of pulmonary lymphangioleiomyomatosis by HMB45 in surgically treated spontaneous pneumothorax. Eur Respir J. 1995;8:1879–1882
  6. Haas CJ, Hirschmann A, Sendelhofert A, et al.  Improvement of nonradioactive DNA in situ hybridization. Biotech Histochem. 1998;73:228–232
  7. Schutze K, Lahr G. Identification of expressed genes by laser-mediated manipulation of single cells. Nat Biotechnol. 1998;16:737–742
  8. Anslinger K, Rolf B, Keil W. Evaluation and application of the AmpF/STR profiler plus PCR amplification kit in a Bavarian population sample. Int J Legal Med. 2001;114:278–280
  9. Moss J, Avila NA, Barnes PM, et al.  Prevalence and clinical characteristics of lymphangioleiomyomatosis (LAM) in patients with tuberous sclerosis complex. Am J Respir Crit Care Med. 2001;164:669–671
  10. Nine JS, Yousem SA, Paradis IL, et al.  Lymphangioleiomyomatosis: Recurrence after lung transplantation. J Heart Lung Transplant. 1994;13:714–719
  11. Robey PG. Stem cells near the century mark. J Clin Invest. 2000;105:1489–1491
  12. Theise ND, Badve S, Saxena R, et al.  Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology. 2000;31:235–240
  13. Lagasse E, Connors H, Al Dhalimy M, et al.  Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med. 2000;6:1229–1234
  14. Ferrari G, Cusella-De Angelis G, Coletta M, et al.  Muscle regeneration by bone marrow-derived myogenic progenitors. Science. 1998;279:1528–1530
  15. Pacheco-Rodriguez G, Kristof AS, Stevens LA, et al.  Giles F. Filley Lecture: Genetics and gene expression in lymphangioleiomyomatosis. Chest. 2002;121:56S–60S
  16. Pechet TT, Singhal AK, Meyers BF, et al.  Lung transplantation for lymphangioleiomyomatosis. J Heart Lung Transplant. 2001;20:174
  17. Logginidou H, Ao X, Russo I, et al.  Frequent estrogen and progesterone receptor immunoreactivity in renal angiomyolipomas from women with pulmonary lymphangioleiomyomatosis. Chest. 2000;117:25–30
  18. Yu J, Astrinidis A, Henske EP. Chromosome 16 loss of heterozygosity in tuberous sclerosis and sporadic lymphangiomyomatosis. Am J Respir Crit Care Med. 2001;164:1537–1540
  19. Wienecke R, Maize JC, Reed JA, et al.  Expression of the TSC2 product tuberin and its target Rap1 in normal human tissues. Am J Pathol. 1997;150:43–50
  20. Goncharova EA, Goncharov DA, Eszterhas A, et al.  Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation: A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). J Biol Chem. 2002;277:30958–30967
  21. Henry KW, Yuan X, Koszewski NJ, et al.  Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members. J Biol Chem. 1998;273:20535–20539
  22. Noonan DJ, Lou D, Griffith N, et al.  A calmodulin binding site in the tuberous sclerosis 2 gene product is essential for regulation of transcription events and is altered by mutations linked to tuberous sclerosis and lymphangioleiomyomatosis. Arch Biochem Biophys. 2002;398:132–140

☆ Address correspondence and reprint requests to Iris Bittmann, MD, Institute of Pathology, Ludwig-Maximilians University, Thalkirchner Str. 36, 80337 Munich, Germany.

PII: S0046-8177(03)00005-4

doi: 10.1053/hupa.2003.50

Human Pathology
Volume 34, Issue 1 , Pages 95-98 , January 2003

Article Tools

* Image Usage & Resolution