« Previous
Next »
Human Pathology
Volume 36, Issue 5
, Pages 536-545
, May 2005
The phosphorylated form of connexin43 is up-regulated in breast hyperplasias and carcinomas and in their neoformed capillaries
References
- . Connexions with connexins: the molecular basis of direct intercellular signaling. Eur J Biochem. 1996;238:1–27
- . The gap junction communication channel. Cell. 1996;84:381–388
- . Connexins, connexons and intercellular communication. Annu Rev Biochem. 1996;65:475–502
- . Three dimensional structure of a recombinant gap junction membrane channel. Science. 1999;283:1176–1180
- Structural and functional diversity of connexin genes in the mouse and human genome. Biol Chem. 2002;383:725–737
- . Regulation of gap junctions by phosphorylation of connexins. Arch Biochem Biophys. 2000;384:205–215
- . Gap junction distribution and connexin expression in the human breast. Exp Cell Res. 1996;223:29–38
- . Rapid modulation of gap junction expression in mouse mammary gland during pregnancy, lactation and involution. J Histochem Cytochem. 1994;42:931–938
- . Steroid hormone regulation of rat myometrial gap junction formation: effects on Cx43 levels and trafficking. Biol Reprod. 1995;52:457–560
- Reduced connexin 43 expression in high grade human prostatic adenocarcinoma cells. Biochem Biophys Res Commun. 1996;227:64–69
- Gap junction intercellular communication and connexin43 expression in human ovarian surface epithelial cells and ovarian carcinomas in vivo and in vitro. Carcinogenesis. 1999;20:1369–1373
- . Reduced levels of connexin43 in cervical dysplasia: inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression. Carcinogenesis. 2000;21:1097–1109
- . Ultrastructural localization of gap junction protein connexin 43 in normal human skin, basal cell carcinoma, and squamous cell carcinoma. J Cutan Pathol. 1997;24:628–635
- Deficiency of connexin43 gap junctions is an independent marker for breast tumors. Cancer Res. 1999;59:4104–4110
- . Expression of gap junction protein connexin 26 and connexin 43 in normal human breast and in breast tumors. J Pathol. 1998;184:37–43
- . Phosphorylation and subcellular distribution of connexin43 in normal and stressed cells. Cell Tissue Res. 2003;311:23–30
- . Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctions. J Cell Biol. 1991;115:1357–1374
- . Selective expression of a novel mucin-type glycoprotein in human tumors. Hum Pathol. 1988;19:623–627
- . Tenascin in normal, hyperplastic and neoplastic tissues. Hum Pathol. 1991;22:636–643
- . Nup 88(karyoporin) in human malignant neoplasms and dysplasias: correlations of immunostaining of tissue sections, cytologic smears, and immunoblot analysis. Hum Pathol. 2002;33:534–536
- . Use of the avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabelled antibody (PAP) procedures. J Histochem Cytochem. 1981;29:577–580
- . Immunohistochemical analysis of Ewing's tumors: patterns of intermediate filaments and desmosomal proteins indicate cell type heterogeneity and pluripotential differentiation. Am J Pathol. 1987;127:288–304
- . Ultrastructural features of papillomatosis and carcinoma of nipple ducts. The significance of myoepithelial cells and basal lamina in benign, “questionable” and malignant lesions. Pathol Annu. 1974;9:441–474
- . Ultrastructural analysis in the differential diagnosis of breast tumors. The significance of myoepithelial cells, basal lamina, intracytoplasmic lumina and secretory granules. Pathol Res Pract. 1980;167:45–70
- Characterization of breast carcinomas by two monoclonal antibodies distinguishing myoepithelial from luminal cells. J Histochem Cytochem. 1986;34:869–881
- . Differential diagnosis of benign epithelial cell proliferations and carcinomas of the breast using antibodies to cytokeratins. Hum Pathol. 1988;19:276–289
- . Coexpression patterns of vimentin and glial filament protein with cytokeratins in the normal, hyperplastic and neoplastic breast. Am J Pathol. 1990;137:1143–1151
- . Ultrastructure of medullary, intraductal, tubular and adenocystic carcinoma. Comparative patterns of myoepithelial differentiation and basal lamina deposition. Am J Pathol. 1975;78:401–416
- . Tyrosine phosphorylation of connexin43 by v-Src is mediated by SH2 and SH3 domain interactions. J Biol Chem. 1997;272:22824–22831
- . Dissection of the molecular basis of pp60(v-src) induced gating of connexin 43 gap junction channels. J Cell Biol. 1999;144:1033–1045
- . Interaction of c-Src with gap junction connexin-43. J Biol Chem. 2001;276:8544–8549
- . Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication. J Cell Biol. 2000;149:1503–1512
- . Epidermal growth factor stimulates the disruption of gap junction communication and connexin43 phosphorylation independent of 12-0-tetradecanoylphorbol 13-acetate-sensitive protein kinase C: the possible involvement of mitogen-activated kinase. Mol Biol Cell. 1993;4:837–848
- Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein. J Biol Chem. 1996;271:3779–3786
- . Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase. J Biol Chem. 1998;273:9188–9196
- . Growth factor receptors on breast cancer: potential for therapeutic intervention. Oncologist. 2003;8:5–17
- . Platelet-derived growth factor-induced disruption of gap junctional communication and phosphorylation of connexin 43 involves protein kinase C and mitogen-activated protein kinase. J Cell Physiol. 1998;176:332–341
- . Tumor necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cells. Cytokine. 1998;10:258–264
- . Distribution of connexin 37, connexin 40 and connexin 43 in the aorta and coronary artery of several mammals. Histochem Cell Biol. 1999;112:479–486
- . Multiple connexin expression in regenerating arterial endothelial gap junctions. Arterioscler Thromb Vasc Biol. 2000;20:1753–1762
- . Downregulation of connexin 43 expression by high glucose reduces gap junction activity in microvascular endothelial cells. Diabetes. 2000;51:1565–1571
- . A mitosis-specific phosphorylation of the gap junction protein connexin43 in human vascular cells: biochemical characterization and localization. J Cell Biol. 1997;137:203–210
- . Angiogenesis: an expanding universe. Hum Path. 2002;33:1061–1063
- . Mechanisms and future directions for angiogenesis-based cancer therapies. J Clin Oncol. 2002;20:3906–3927
- . Increased invasive capacity of connexin-43 malignant glioma cells. J Neurosurg. 2003;99:1039–1046
PII: S0046-8177(05)00164-4
doi: 10.1016/j.humpath.2005.03.013
© 2005 Elsevier Inc. All rights reserved.
« Previous
Next »
Human Pathology
Volume 36, Issue 5
, Pages 536-545
, May 2005
