Human Pathology
Volume 37, Issue 1 , Pages 32-39 , January 2006

Lesions resembling Langerhans cell histiocytosis in association with other lymphoproliferative disorders: a reactive or neoplastic phenomenon?

  • Lesley J. Christie, MB, ChB (Clinical Lecturer and Specialist Registrar)

      Affiliations

    • Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    • Corresponding Author InformationCorresponding author.
    • ,
  • Alan T. Evans, MD

      Affiliations

    • Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    • ,
  • Susan E. Bray, PhD

      Affiliations

    • Department of Surgery, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    • ,
  • Mark E.F. Smith, PhD

      Affiliations

    • Department of Histopathology, Derriford Hospital, Plymouth, PL6 8DH, UK
    • ,
  • Neil M. Kernohan, PhD

      Affiliations

    • Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    • ,
  • David A. Levison, MD

      Affiliations

    • Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    • ,
  • John R. Goodlad, MD

      Affiliations

    • Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    • Department of Pathology, Western General Hospital, Edinburgh, EH4 2XU, UK

Received 24 June 2005 ,Revised 26 August 2005 ,Accepted 30 August 2005.

References 

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  4. Segal GH, Mesa MV, Fishleder AJ, et al. Precursor Langerhans cell histiocytosis. An unusual histiocytic proliferation in a patient with persistent non–Hodgkin lymphoma and terminal acute monocytic leukaemia. Cancer. 1992;70:547–553
  5. Egeler RN, Neglia JP, Puccetti DM, et al. Association of Langerhans cell histiocytosis with malignant neoplasms. Cancer. 1993;71:865–873
  6. Egeler RM, Neglia JP, Arico M, et al. The relation of Langerhans cell histiocytosis to acute leukaemia, lymphomas, and other solid tumors. Hematol Oncol Clin North Am. 1998;12:369–378
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  9. Izikson L, Vanderpool J, Brodsky G, et al. Combined basal cell carcinoma and Langerhans cell histiocytosis of the scrotum in a patient with occupational exposure to coal tar and dust. Int J Dermatol. 2004;43:678–680
  10. Richmond I, Eyden BP, Banerjee SS. Intranodal Langerhans cell histiocytosis associated with malignant melanoma. Histopathology. 1995;26:380–382
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  13. Adu-Poku K, Thomas DW, Khan MK, et al. Langerhans cell histiocytosis in sequential discordant lymphoma. J Clin Pathol. 2005;58:104–106
  14. Yousem SA, Colby TV, Chen YY, et al. Pulmonary Langerhans cell histiocytosis: molecular analysis of clonality. Am J Surg Pathol. 2001;25:630–636
  15. Busque L, Zhu J, DeHart D, et al. An expression based clonality assay at the human androgen receptor locus (HUMARA) on chromosome X. Nucleic Acids Res. 1994;22:697–698
  16. Fialkow PJ. The origin and development of human tumors studied with cell markers. N Engl J Med. 1974;291:26–35
  17. Li S, Borowitz MJ. CD79a(+) T-cell lymphoblastic lymphoma with coexisting Langerhans cell histiocytosis. Arch Pathol Lab Med. 2001;125:958–960
  18. Yu RC, Chu C, Buluwela L, et al. Clonal proliferation of Langerhans cells in Langerhans cell histiocytosis. Lancet. 1994;26:767–768
  19. Willman CL. Detection of clonal histiocytes in Langerhans cell histiocytosis: biology and clinical significance. Br J Cancer Suppl. 1994;23:S29–S33
  20. Willman CL, Busque L, Griffith BB, et al. Langerhans cell histiocytosis (histiocytosis X)—a clonal proliferative disease. N Engl J Med. 1994;331:154–160
  21. Wu CD, Wickert RS, Williamson JE, et al. Using fluorescence-based human androgen receptor gene assay to analyse the clonality of microdissected dendritic cell tumors. Am J Clin Pathol. 1999;111:105–110

☆ John Goodlad's part-time Senior Clinical Research Fellowship in the Division of Pathology and Neurosciences, University of Dundee Medical School, Dundee, UK, is funded by the Leng Charitable Trust and Ninewells Cancer Campaign, Dundee, UK. A local “Anonymous Trust” provided funding toward the use of the laser capture microscope.

PII: S0046-8177(05)00462-4

doi: 10.1016/j.humpath.2005.08.024

Human Pathology
Volume 37, Issue 1 , Pages 32-39 , January 2006

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