Inflammatory myofibroblastic tumor with ALK/TPM3 fusion presenting as ileocolic intussusception: an unusual presentation of an unusual neoplasm

Milne, Anya N.A.; Sweeney, Karl J.; O'Riordain, Diarmuid S.; Pauwels, Patrick; Debiec-Rychter, Maria; Offerhaus, G. Johan A.; Jeffers, Michael

doi:10.1016/j.humpath.2005.09.012

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Volume 37, Issue 1 , Pages 112-116, January 2006

Inflammatory myofibroblastic tumor with ALK/TPM3 fusion presenting as ileocolic intussusception: an unusual presentation of an unusual neoplasm☆

Anya N.A. Milne, MB, Ba(Mod)
- Department of Pathology, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands
- Corresponding author.
Karl J. Sweeney, MD, AFRCSI
- Department of Surgery, The Adelaide and Meath Hospital, Dublin 16, Ireland
Diarmuid S. O'Riordain, MD, FRCSI
- Department of Surgery, The Adelaide and Meath Hospital, Dublin 16, Ireland
Patrick Pauwels, MD, PhD
- Department of Pathology, Maastricht Academic Hospital, 6202 AZ Maastricht, The Netherlands
Maria Debiec-Rychter, MD, PhD
- Centre for Human Genetics, University of Leuven, 3000 Leuven, Belgium
G. Johan A. Offerhaus, MD, PhD
- Department of Pathology, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands
Michael Jeffers, MRCPath
- Department of Cellular Pathology, The Adelaide and Meath Hospital, Dublin 16, Ireland

Received 5 July 2005; accepted 15 September 2005. published online 28 November 2005.

Summary

Inflammatory myofibroblastic tumor is a rare spindle cell lesion of indeterminate malignant potential occurring in both pulmonary and extrapulmonary tissues. This report describes an unusual presentation of an unusual tumor at an unusual location: an intramural ileal case of inflammatory myofibroblastic tumor presenting with intussusception in a 29-year-old woman. We characterize this tumor through microscopic and ultrastructural analysis, extensive immunohistochemical analysis, ploidy analysis, and Epstein-Barr virus in situ hybridization, and we report the finding of an ALK/TPM3 fusion using fluorescence in situ hybridization.

Keywords: Inflammatory myofibroblastic tumor, Intussusception, Anaplastic lymphoma kinase