Human Pathology
Volume 37, Issue 1 , Pages 101-111, January 2006

Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors☆

  • Martine Cools, MD

      Affiliations

    • Department of Pathology, Josephine Nefkens Institute, Erasmus MC–University Medical Center, Daniel den Hoed, 3000 DR Rotterdam, The Netherlands
    • ,
  • Friedemann Honecker, MD

      Affiliations

    • Department of Pathology, Josephine Nefkens Institute, Erasmus MC–University Medical Center, Daniel den Hoed, 3000 DR Rotterdam, The Netherlands
    • Department of Oncology/Hematology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
    • ,
  • Hans Stoop, BSc

      Affiliations

    • Department of Pathology, Josephine Nefkens Institute, Erasmus MC–University Medical Center, Daniel den Hoed, 3000 DR Rotterdam, The Netherlands
    • ,
  • Joris D. Veltman, BSc

      Affiliations

    • Department of Pathology, Josephine Nefkens Institute, Erasmus MC–University Medical Center, Daniel den Hoed, 3000 DR Rotterdam, The Netherlands
    • ,
  • Ronald R. de Krijger, MD, PhD

      Affiliations

    • Department of Pathology, Josephine Nefkens Institute, Erasmus MC–University Medical Center, Daniel den Hoed, 3000 DR Rotterdam, The Netherlands
    • ,
  • Ewout Steyerberg, PhD

      Affiliations

    • Department of Public Health, Center for Clinical Decision Science, Erasmus MC–University Medical Center, 3000 DR Rotterdam, The Netherlands
    • ,
  • Katja P. Wolffenbuttel, MD

      Affiliations

    • Department of Pediatric Urology, Sophia Children's Hospital, Erasmus MC–University Medical Center, 3000 DR Rotterdam, The Netherlands
    • ,
  • Carsten Bokemeyer, MD, PhD

      Affiliations

    • Department of Oncology/Hematology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
    • ,
  • Yun-Fai Chris Lau, PhD

      Affiliations

    • Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, University of California, San Francisco, CA 94121, USA
    • ,
  • Stenvert L.S. Drop, MD, PhD

      Affiliations

    • Department of Pediatric Endocrinology, Sophia Children's Hospital, Erasmus MC–University Medical Center, 3000 DR Rotterdam, The Netherlands
    • ,
  • Leendert H.J. Looijenga, PhD

      Affiliations

    • Department of Pathology, Josephine Nefkens Institute, Erasmus MC–University Medical Center, Daniel den Hoed, 3000 DR Rotterdam, The Netherlands
    • Corresponding Author InformationCorresponding author.

Received 29 March 2005; accepted 24 September 2005.

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☆ This study was financially supported by the ESPE Research Fellowship which is sponsored by Novo Nordisk (Copenhagen, Denmark), the Deutsche Krebshilfe (Bonn, Germany), and the Dutch Cancer Society (Amsterdam, The Netherlands).

PII: S0046-8177(05)00536-8

doi:10.1016/j.humpath.2005.09.021

Human Pathology
Volume 37, Issue 1 , Pages 101-111, January 2006

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