Human Pathology
Volume 37, Issue 3 , Pages 298-311, March 2006

Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells☆

  • Xing Cui, MD, PhD

      Affiliations

    • Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, Japan
    • Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951-8510, Japan
    • Corresponding Author InformationCorresponding author. Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, Japan.
    • ,
  • Toshifumi Wakai, MD, PhD

      Affiliations

    • Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951-8510, Japan
    • ,
  • Yoshio Shirai, MD, PhD

      Affiliations

    • Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951-8510, Japan
    • ,
  • Naoyuki Yokoyama, MD, PhD

      Affiliations

    • Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951-8510, Japan
    • ,
  • Katsuyoshi Hatakeyama, MD, PhD

      Affiliations

    • Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951-8510, Japan
    • ,
  • Seishiro Hirano, PhD

      Affiliations

    • Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, Japan

Received 6 July 2005; received in revised form 27 October 2005; accepted 27 October 2005. published online 16 December 2005.

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.

☆ Grant Support: This study was supported in part by Grants-in-aid for Scientific Research (Young Scientists B, no. 14780433) from the Japan Society for the Promotion of Science (to Dr Cui).

PII: S0046-8177(05)00606-4

doi:10.1016/j.humpath.2005.10.013

Human Pathology
Volume 37, Issue 3 , Pages 298-311, March 2006

Article Tools

* Image Usage & Resolution