Human Pathology
Volume 37, Issue 3 , Pages 298-311 , March 2006

Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells

  • Xing Cui, MD, PhD

      Affiliations

    • Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, Japan
    • Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951-8510, Japan
    • Corresponding Author InformationCorresponding author. Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, Japan.
    • ,
  • Toshifumi Wakai, MD, PhD

      Affiliations

    • Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951-8510, Japan
    • ,
  • Yoshio Shirai, MD, PhD

      Affiliations

    • Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951-8510, Japan
    • ,
  • Naoyuki Yokoyama, MD, PhD

      Affiliations

    • Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951-8510, Japan
    • ,
  • Katsuyoshi Hatakeyama, MD, PhD

      Affiliations

    • Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City 951-8510, Japan
    • ,
  • Seishiro Hirano, PhD

      Affiliations

    • Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, Japan

Received 6 July 2005 ,Revised 27 October 2005 ,Accepted 27 October 2005.

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☆ Grant Support: This study was supported in part by Grants-in-aid for Scientific Research (Young Scientists B, no. 14780433) from the Japan Society for the Promotion of Science (to Dr Cui).

PII: S0046-8177(05)00606-4

doi: 10.1016/j.humpath.2005.10.013

Human Pathology
Volume 37, Issue 3 , Pages 298-311 , March 2006

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