Human Pathology
Volume 38, Issue 2 , Pages 205-211 , February 2007

Immunohistochemistry of primary malignant neuroepithelial tumors of the kidney: a potential source of confusion? A study of 30 cases from the National Wilms Tumor Study Pathology Center

  • Dale A. Ellison, MD

      Affiliations

    • Department of Pathology, Arkansas Children's Hospital and University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    • Corresponding Author InformationCorresponding author. Little Rock, AR 72202, USA.
    • ,
  • David M. Parham, MD

      Affiliations

    • Department of Pathology, Arkansas Children's Hospital and University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    • Department of Pediatrics, Arkansas Children's Hospital and University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    • ,
  • Julia Bridge, MD

      Affiliations

    • Department of Pathology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    • Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE 68198, USA
    • Department of Orthopedic Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    • ,
  • J. Bruce Beckwith, MD

      Affiliations

    • Department of Pathology and Human Anatomy, Loma Linda University, Loma Linda, CA 92350, USA
    • Current address: Missoula, Montana.

Received 19 April 2006 ,Revised 22 August 2006 ,Accepted 23 August 2006.

References 

  1. Rodriguez-Galindo C, Marina NM, Fletcher BD, Parham DM, Bodfner SM, Meyer WH. Is primitive neuroectodermal tumor of the kidney a distinct entity?. Cancer. 1997;79:2243–2250
  2. Murphy WM, Grignon DJ, Perlman EJ. Tumors of the kidney, bladder, and related urinary structures. Ed. 4th series. Washington (DC): American Registry of Pathology; 2004;
  3. Green DM. The treatment of stages I-IV favorable histology Wilms' tumor. J Clin Oncol. 2004;22:1366–1372
  4. Casella R, Moch H, Rochlitz C, et al. Metastatic primitive neuroectodermal tumor of the kidney in adults. Eur Urol. 2001;39:613–617
  5. Juan CJ, Wu CJ, Chen CY, Lee SS, Chen A, Fan HC. Primitive neuroectodermal tumor of the kidney associated with Budd-Chiari syndrome in a 17-year-old girl. J Formos Med Assoc. 2001;100:628–630
  6. Lam JS, Hensle TW, Debelenko L, Granowetter L, Tennenbaum SY. Organ-confined primitive neuroectodermal tumor arising from the kidney. J Pediatr Surg. 2003;38:619–621
  7. Jimenez RE, Folpe AL, Lapham RL, et al. Primary Ewing's sarcoma/primitive neuroectodermal tumor of the kidney: a clinicopathologic and immunohistochemical analysis of 11 cases. Am J Surg Pathol. 2002;26:320–327
  8. Folpe AL, Hill CE, Parham DM, O'Shea PA, Weiss SW. Immunohistochemical detection of FLI-1 protein expression: a study of 132 round cell tumors with emphasis on CD99-positive mimics of Ewing's sarcoma/primitive neuroectodermal tumor. Am J Surg Pathol. 2000;24:1657–1662
  9. Sorensen PH, Liu XF, Delattre O, et al. Reverse transcriptase PCR amplification of EWS/FLI-1 fusion transcripts as a diagnostic test for peripheral primitive neuroectodermal tumors of childhood. Diagn Mol Pathol. 1993;2:147–157
  10. Folpe AL, Hill CE, Parham DM, O'Shea PA, Weiss SW. Immunohistochemical detection of FLI-1 protein expression: a study of 132 round cell tumors with emphasis on CD99-positive mimics of Ewing's sarcoma/primitive neuroectodermal tumor. Am J Surg Pathol. 2000;24:1657–1662
  11. Jimenez RE, Folpe AL, Lapham RL, et al. Primary Ewing's sarcoma/primitive neuroectodermal tumor of the kidney: a clinicopathologic and immunohistochemical analysis of 11 cases. Am J Surg Pathol. 2002;26:320–327
  12. Nakadate H, Yokomori K, Watanabe N, et al. Mutations/deletions of the WT1 gene, loss of heterozygosity on chromosome arms 11p and 11q, chromosome ploidy and histology in Wilms' tumors in Japan. Int J Cancer. 2001;94:396–400
  13. Thorner P, Squire J, Plavsic N, Jong R, Greenberg M, Zielenska M. Expression of WT1 in pediatric small cell tumors: report of two cases with a possible mesothelial origin. Pediatric and Developmental Pathology. 1999;2:33–41
  14. Parham DM, Roloson GJ, Feely M, Green DM, Bridge JA, Beckwith JB. Primary malignant neuroepithelial tumors of the kidney: a clinicopathologic analysis of 146 adult and pediatric cases from the National Wilms' Tumor Study Group Pathology Center. Am J Surg Pathol. 2001;25:133–146
  15. Rossi S, Orvieto E, Furlanetto A, Laurinos L, Ninfo V, Dei Tos AP. Utility of the immunohistochemical detection of FLI-1 expression in round cell and vascular neoplasm using a monoclonal antibody. Mod Pathol. 2004;17:547–552
  16. Argani P, Faria PA, Epstein JI, et al. Primary renal synovial sarcoma: molecular and morphologic delineation of an entity previously included among embryonal sarcomas of the kidney. Am J Surg Pathol. 2000;24:1087–1096
  17. Lae ME, Roche PC, Jin L, Lloyd RV, Nascimento AG. Desmoplastic small round cell tumor: a clinicopathologic, immunohistochemical, and molecular study of 32 tumors. Am J Surg Pathol. 2002;26:823–835
  18. Su MC, Jeng YM, Chu YC. Desmoplastic small round cell tumor of the kidney. Am J Surg Pathol. 2004;28:1379–1383
  19. Mierau GW, Berry PJ, Malott RL, Weeks DA. Appraisal of the comparative utility of immunohistochemistry and electron microscopy in the diagnosis of childhood round cell tumors. Ultrastruct Pathol. 1996;20:507–517

 Presented at the interim meeting of the Society for Pediatric Pathology, Little Rock, AR, October, 2004.

PII: S0046-8177(06)00533-8

doi: 10.1016/j.humpath.2006.08.026

Human Pathology
Volume 38, Issue 2 , Pages 205-211 , February 2007

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