Human Pathology
Volume 39, Issue 8 , Pages 1258-1262 , August 2008

Insights from a whole cystectomy specimen—association of primary small cell carcinoma of the bladder with transitional cell carcinoma in situ

  • Nadine Therese Gaisa, MD

      Affiliations

    • Institute of Pathology, RWTH Aachen University, 52074 Aachen, Germany
    • ,
  • Derya Tilki, MD

      Affiliations

    • Department of Urology, University Hospital Munich-Großhadern, LMU Munich, 81377 München, Germany
    • ,
  • Inge Losen

      Affiliations

    • Institute of Pathology, RWTH Aachen University, 52074 Aachen, Germany
    • ,
  • Edgar Dahl, PhD

      Affiliations

    • Institute of Pathology, RWTH Aachen University, 52074 Aachen, Germany
    • ,
  • Robert Stoehr, PhD

      Affiliations

    • Institute of Pathology, University Hospital Erlangen, 91054 Erlangen, Germany
    • ,
  • Christian Georg Stief, MD

      Affiliations

    • Department of Urology, University Hospital Munich-Großhadern, LMU Munich, 81377 München, Germany
    • ,
  • Ruth Knüchel, MD

      Affiliations

    • Institute of Pathology, RWTH Aachen University, 52074 Aachen, Germany
    • Corresponding Author InformationCorresponding author. Institute of Pathology, RWTH Aachen University, 52074 Aachen, Germany.

Received 7 December 2007 ,Accepted 27 December 2007.

References 

  1. Cheng L, Pan CX, Yang XJ, et al. Small cell carcinoma of the urinary bladder: a clinicopathologic analysis of 64 patients. Cancer. 2004;101:957–962
  2. Sved P, Gomez P, Manoharan M, Civantos F, Soloway MS. Small cell carcinoma of the bladder. BJU Int. 2004;94:12–17
  3. Smith A. Neurosecretory cells in carcinoma in situ of the urinary bladder—an incidental finding. Ultrastruct Pathol. 1985;8:267
  4. Fetissof F, Dubois MP, Arbeille-Brassart B, Lanson Y, Boivin F, Jobard P. Endocrine cells in the prostate gland, urothelium and Brenner tumors. Immunohistological and ultrastructural studies. Virchows Arch B Cell Pathol Incl Mol Pathol. 1983;42:53–64
  5. Trias I, Algaba F, Condom E, et al. Small cell carcinoma of the urinary bladder. Presentation of 23 cases and review of 134 published cases. Eur Urol. 2001;39:85–90
  6. Stoehr R, Zietz S, Burger M, et al. Deletions of chromosomes 9 and 8p in histologically normal urothelium in patients with bladder cancer. Eur Urol. 2005;47:58–63
  7. Cheng L, Jones TD, McCarthy RP, et al. Molecular genetic evidence for a common clonal origin of urinary bladder small cell carcinoma and co-existing urothelial carcinoma. Am J Pathol. 2005;166:1533–1539
  8. Terracciano L, Richter J, Tornillo L, et al. Chromosomal imbalances in small cell carcinomas of the urinary bladder. J Pathol. 1999;189:230–235

PII: S0046-8177(08)00005-1

doi: 10.1016/j.humpath.2007.12.017

Human Pathology
Volume 39, Issue 8 , Pages 1258-1262 , August 2008

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