Human Pathology
Volume 39, Issue 10 , Pages 1446-1453 , October 2008

CD10 Immunostaining distinguishes atypical polypoid adenomyofibroma (atypical polypoid adenomyoma) from endometrial carcinoma invading the myometrium

  • Yoshihiro Ohishi, MD, PhD

      Affiliations

    • Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • Corresponding Author InformationCorresponding author. Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
    • ,
  • Tsunehisa Kaku, MD, PhD

      Affiliations

    • Division of Maternal Health, Department of Health Sciences, School of Medicine, Kyushu University, Fukuoka, Japan
    • ,
  • Hiroaki Kobayashi, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Kyushu University Hospital, Fukuoka, Japan
    • ,
  • Shinichi Aishima, MD, PhD

      Affiliations

    • Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    • ,
  • Yoshihisa Umekita, MD, PhD

      Affiliations

    • Field of Oncology, Department of Tumor Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    • ,
  • Norio Wake, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Kyushu University Hospital, Fukuoka, Japan
    • ,
  • Masazumi Tsuneyoshi, MD, PhD

      Affiliations

    • Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Received 1 November 2007 ,Revised 12 February 2008 ,Accepted 18 February 2008.

References 

  1. Mazur MT. Atypical polypoid adenomyomas of the endometrium. Am J Surg Pathol. 1981;5:473–482
  2. Longacre TA, Chung H, Rouse RV, Hendrickson MR. Atypical polypoid adenomyofibromas (atypical polypoid adenomyomas) of the uterus: a clinicopathologic study of 55 cases. Am J Surg Pathol. 1996;20:1–20
  3. Soslow RA, Chung MH, Rouse RV, Hendrickson MR, Longacre TA. Atypical polypoid adenomyofibroma (APA) versus well-differentiated endometrial carcinoma with prominent stromal matrix: an immunohistochemical study. Int J Gynecol Pathol. 1996;15:209–216
  4. Greaves MF, Hariri G, Newman RA, Sutherland DR, Ritter MA, Ritz J. Selective expression of the common acute lymphoblastic leukemia (gp100) antigen on immature lymphoid cells and their malignant counterparts. Blood. 1983;61:628–639
  5. Weiss LM, Bindl JM, Picozzi VJ, Link MP, Warnke RA. Lymphoblastic lymphoma: an immunophenotype study of 26 cases with comparison to T cell acute lymphoblastic leukemia. Blood. 1986;67:474–478
  6. Gregory CD, Tursz T, Edwards CF, Tetaud C, Talbot M, Caillou B, et al. Identification of a subset of normal B cells with a Burkitt's lymphoma (BL)-like phenotype. J Immunol. 1987;139:313–318
  7. Stein H, Lennert K, Feller AC, Mason DY. Immunohistological analysis of human lymphoma: correlation of histological and immunological categories. Adv Cancer Res. 1984;42:67–147
  8. Chu P, Arber DA. Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms. Frequent expression in renal cell carcinoma and endometrial stromal sarcoma. Am J Clin Pathol. 2000;113:374–382
  9. McCluggage WG, Sumathi VP, Maxwell P. CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stromal and of endometrial stromal neoplasms. Histopathology. 2001;39:273–278
  10. Srodon M, Klein WM, Kurman RJ. CD10 immunostaining does not distinguish endometrial carcinoma invading myometrium from carcinoma involving adenomyosis. Am J Surg Pathol. 2003;27:786–789
  11. Nascimento AF, Hirsch MS, Cviko A, Quade BJ, Nucci MR. The role of CD10 staining in distinguishing invasive endometrial adenocarcinoma from adenocarcinoma involving adenomyosis. Mod Pathol. 2003;16(1):22–27
  12. Sugiyama T, Ohta S, Nishida T, Okura N, Tanabe K, Yakushiji M. Two cases of endometrial adenocarcinoma arising from atypical polypoid adenomyoma. Gynecol Oncol. 1998;71:141–144
  13. Lee KR. Atypical polypoid adenomyoma of the endometrium associated with adenomyomatosis and adenocarcinoma. Gynecol Oncol. 1993;51:416–418
  14. Young RH, Treger T, Scully RE. Atypical polypoid adenomyoma of the uterus. A report of 27 cases. Am J Clin Pathol. 1986;86:139–145
  15. Fukunaga M, Endo Y, Ushigome S, Ishikawa E. Atypical polypoid adenomyomas of the uterus. Histopathology. 1995;27:35–42
  16. Mittal KR, Peng XC, Wallach RC, Demopoulos RI. Coexistent atypical polypoid adenomyoma and endometrial adenocarcinoma. Hum Pathol. 1995;26:574–576
  17. Chiarelli S, Buritica C, Litta P, Ciani S, Guarch R, Nogales FF. An immunohistochemical study of morules in endometrioid lesions of female genital tract: CD10 is a characteristic marker of morular metaplasia. Clin Cancer Res. 2006;12:4251–4256
  18. Mikami Y, Hata S, Kiyokawa T, Manabe T. Expression of CD10 in malignant mullerian mixed tumors and adenosarcomas: an immunohistochemical study. Mod Pathol. 2001;15(9):923–930
  19. McCluggage WG, Oliva E, Herrington CS, McBride H, Young RH. CD10 and calretinin staining of endocervical glandular lesions, endocervical stroma and endometrioid adenocarcinomas of the uterine corpus: CD10 positivity is characteristic of, but not specific for, mesonephric lesions and is not specific for endometrial stroma. Histopathology. 2003;43:144–150
  20. Ogawa H, Iwaya K, Izumi M, et al. Expression of CD10 by stromal cells during colorectal tumor development. Hum Pathol. 2002;33:806–811
  21. Makretsov NA, Hayes M, Carter BA, Dabiri S, Gilks CB, Huntsman DG. Stromal CD10 expression in invasive breast carcinoma correlates with poor prognosis, estrogen receptor negativity, and high grade. Mod Pathol. 2007;20:84–89
  22. Oliva E, Young RH, Amin MB, Clement PB. An immunohistochemical analysis of endometrial stromal and smooth muscle tumors of the uterus: a study of 54 cases emphasizing the importance of using a panel because of overlap in immunoreactivity for individual antibodies. Am J Surg Pathol. 2002;26(4):403–412
  23. Meis-Kindblom JM, Enzinger FM. In: Fibrous tissue tumors. Mosby-Wolfe: Color Atlas of Soft Tissue Tumors; 1996;p. 1–44
  24. Yilmaz A, Rush DS, Soslow RA. Endometrial stromal sarcomas with unusual histologic features: a report of 24 primary and metastatic tumors emphasizing fibroblastic and smooth muscle differentiation. Am J Surg Pathol. 2002;26:1142–1150

PII: S0046-8177(08)00105-6

doi: 10.1016/j.humpath.2008.02.006

Human Pathology
Volume 39, Issue 10 , Pages 1446-1453 , October 2008

Article Tools

* Image Usage & Resolution