Human Pathology
Volume 39, Issue 10 , Pages 1431-1437, October 2008

The combination of high cyclin E and Skp2 expression in breast cancer is associated with a poor prognosis and the basal phenotype☆☆☆

  • David Voduc, MD, FRCPC

      Affiliations

    • Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 4E6
    • Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, British Columbia, Canada V6J 3Z6
    • Corresponding Author InformationCorresponding author. Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada V5Z 4E6.
    • ,
  • Torsten O. Nielsen, MD, PhD

      Affiliations

    • Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, British Columbia, Canada V6J 3Z6
    • Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada V5Z 1M9
    • ,
  • Maggie C. Cheang, MMedSc

      Affiliations

    • Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, British Columbia, Canada V6J 3Z6
    • ,
  • William D. Foulkes, MD, PhD

      Affiliations

    • Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montreal, Quebec, Canada H2W 1S6

Received 8 October 2007; received in revised form 5 March 2008; accepted 11 March 2008. published online 14 July 2008.

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☆ This study examines a novel combination of breast cancer immunohistochemical biomarkers on a large tissue microarray with long follow-up. We show that this combination has prognostic value and is closely associated with the basal breast cancer phenotype.

☆☆ This work was supported by a grant from the Canadian Breast Cancer Research Alliance to WDF and TON. The Genetic Pathology Evaluation Centre is supported by an unrestricted educational grant from Sanofi-Aventis.

PII: S0046-8177(08)00134-2

doi:10.1016/j.humpath.2008.03.004

Human Pathology
Volume 39, Issue 10 , Pages 1431-1437, October 2008

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