Human Pathology
Volume 40, Issue 4 , Pages 516-526 , April 2009

Clinicopathologic spectrum of massive and submassive hepatic necrosis in infants and children

  • Richard Kirsch, MBChB, PhD, FCPath(Anat), FRCPC

      Affiliations

    • Division of Pathology, Department of Pediatric Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X8 Canada
    • Corresponding Author InformationCorresponding author. Mount Sinai Hospital, 600 University Avenue, Toronto, Canada M5G 1X8.
    • ,
  • Jason Yap, MBChB, FRCAP

      Affiliations

    • Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, M5G 1X8 Canada
    • ,
  • Eve A. Roberts, MD, FRCPC

      Affiliations

    • Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, M5G 1X8 Canada
    • ,
  • Ernest Cutz, MD, FRCPC

      Affiliations

    • Division of Pathology, Department of Pediatric Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X8 Canada

Received 23 February 2008 ,Revised 23 July 2008 ,Accepted 28 July 2008.

References 

  1. Cochran JB, Losek JD. Acute liver failure in children. Pediatr Emerg Care. 2007;23:129–135
  2. Dhawan A, Cheeseman P, Mieli-Vergani G. Approaches to acute liver failure in children. Pediatr Transplant. 2004;8:584–588
  3. Treem WR. Fulminant hepatic failure in children. J Pediatr Gastroenterol Nutr. 2002;35(Suppl 1):S33–S38
  4. Devictor D, Desplanques L, Debray D, et al. Emergency liver transplantation for fulminant liver failure in infants and children. Hepatology. 1992;16:1156–1162
  5. Psacharopoulos HT, Mowat AP, Davies M, Portmann B, Silk DB, Williams R. Fulminant hepatic failure in childhood: an analysis of 31 cases. Arch Dis Child. 1980;55:252–258
  6. Rivera-Penera T, Moreno J, Skaff C, McDiarmid S, Vargas J, Ament ME. Delayed encephalopathy in fulminant hepatic failure in the pediatric population and the role of liver transplantation. J Pediatr Gastroenterol Nutr. 1997;24:128–134
  7. Bendre SV, Bavdekar AR, Bhave SA, Pandit AN, Chitambar SD, Arankalle VA. Fulminant hepatic failure: etiology, viral markers and outcome. Indian Pediatr. 1999;36:1107–1112
  8. Ciocca M, Moreira-Silva SF, Alegria S, et al. Hepatitis A as an etiologic agent of acute liver failure in Latin America. Pediatr Infect Dis J. 2007;26:711–715
  9. Ciocca ME, Ramonet MD, Cuarterolo ML, Lopez SI, Cernadas C, Alvarez F. Prognostic factors in pediatric acute liver failure. Arch Dis Child. 2008;93:48–51
  10. Hanna JN, Warnock TH, Shepherd RW, Selvey LA. Fulminant hepatitis A in indigenous children in north Queensland. Med J Aust. 2000;172:19–21
  11. Moreira-Silva SF, Frauches DO, Almeida AL, Mendonca HF, Pereira FE. Acute liver failure in children: observations in Vitoria, Espirito Santo State, Brazil. Rev Soc Bras Med Trop. 2002;35:483–486
  12. Poddar U, Thapa BR, Prasad A, Sharma AK, Singh K. Natural history and risk factors in fulminant hepatic failure. Arch Dis Child. 2002;87:54–56
  13. Shah U, Habib Z, Kleinman RE. Liver failure attributable to hepatitis A virus infection in a developing country. Pediatrics. 2000;105:436–438
  14. Zacarias J, Brinck P, Cordero J, Velasco M. Etiologies of fulminant hepatitis in pediatric patients in Santiago, Chile. Pediatr Infect Dis J. 1987;6:686–687
  15. Khuroo MS, Kamili S. Aetiology and prognostic factors in acute liver failure in India. J Viral Hepat. 2003;10:224–231
  16. Aydogdu S, Ozgenc F, Yurtsever S, Akman SA, Tokat Y, Yagci RV. Our experience with fulminant hepatic failure in Turkish children: etiology and outcome. J Trop Pediatr. 2003;49:367–370
  17. Lee WS, McKiernan P, Kelly DA. Etiology, outcome and prognostic indicators of childhood fulminant hepatic failure in the United kingdom. J Pediatr Gastroenterol Nutr. 2005;40:575–581
  18. Squires RH, Shneider BL, Bucuvalas J, et al. Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. J Pediatr. 2006;148:652–658
  19. Ferrell LCP, Wright T, et al. Predictive value of pretransplant liver biopsy in patients with fulminant/subfulminant hepatitis. Mod Pathol. 1993;6:109A
  20. Hanau C, Munoz SJ, Rubin R. Histopathological heterogeneity in fulminant hepatic failure. Hepatology. 1995;21:345–351
  21. Chan PC, Chen HL, Ni YH, et al. Outcome predictors of fulminant hepatic failure in children. J Formos Med Assoc. 2004;103:432–436
  22. Ferrell LDTN, Scheuer PJ. Acute and chronic viral hepatitis. In:  Mac Sween RNM,  Burt AD,  Portmann BC,  Ishak KG,  Scheuer PJ,  Anthony PP editor. Pathology of the Liver. 4th ed.. London, United Kingdom: Churchill Livingstone; 2000;
  23. Horney JT, Galambos JT. The liver during and after fulminant hepatitis. Gastroenterology. 1977;73:639–645
  24. Phillips MJ, Poucell S. Modern aspects of the morphology of viral hepatitis. Hum Pathol. 1981;12:1060–1084
  25. Hadzic N, Height S, Ball S, et al. Evolution in the management of acute liver failure-associated aplastic anemia in children: a single centre experience. J Hepatol. 2008;48:68–73
  26. Fimmel CJ, Guo L, Compans RW, et al. A case of syncytial giant cell hepatitis with features of a paramyxoviral infection. Am J Gastroenterol. 1998;93:1931–1937
  27. Hicks J, Barrish J, Zhu SH. Neonatal syncytial giant cell hepatitis with paramyxoviral-like inclusions. Ultrastruct Pathol. 2001;25:65–71
  28. Phillips MJ, Blendis LM, Poucell S, et al. Syncytial giant-cell hepatitis. Sporadic hepatitis with distinctive pathological features, a severe clinical course, and paramyxoviral features. N Engl J Med. 1991;324:455–460
  29. Ben-Ari Z, Broida E, Monselise Y, et al. Syncytial giant-cell hepatitis due to autoimmune hepatitis type II (LKM1+) presenting as subfulminant hepatitis. Am J Gastroenterol. 2000;95:799–801
  30. Fraquelli M, Colli A, Cocciolo M, Conte D. Adult syncytial giant cell chronic hepatitis due to herbal remedy. J Hepatol. 2000;33:505–508
  31. Kryczka W, Walewska-Zielecka B, Dutkiewicz E. Acute seronegative hepatitis C manifesting itself as adult giant cell hepatitis—a case report and review of literature. Med Sci Monit. 2003;9(Suppl 3):29–31
  32. Moreno A, Moreno A, Perez-Elias MJ, et al. Syncytial giant cell hepatitis in human immunodeficiency virus-infected patients with chronic hepatitis C: 2 cases and review of the literature. Hum Pathol. 2006;37:1344–1349
  33. Demetris AJ. Central venulitis in liver allografts: considerations of differential diagnosis. Hepatology. 2001;33:1329–1330
  34. Krasinskas AM, Ruchelli ED, Rand EB, Chittams JL, Furth EE. Central venulitis in pediatric liver allografts. Hepatology. 2001;33:1141–1147
  35. Lory J, Zimmermann A. Endotheliitis-like changes in chronic hepatitis C. Histol Histopathol. 1997;12:359–366
  36. Donaldson BW, Gopinath R, Wanless IR, et al. The role of transjugular liver biopsy in fulminant liver failure: relation to other prognostic indicators. Hepatology. 1993;18:1370–1376

PII: S0046-8177(08)00447-4

doi: 10.1016/j.humpath.2008.07.018

Human Pathology
Volume 40, Issue 4 , Pages 516-526 , April 2009

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