Human Pathology
Volume 40, Issue 7 , Pages 950-956 , July 2009

Caspases and inhibitor of apoptosis proteins in cutaneous and mucosal melanoma: expression profile and clinicopathologic significance

  • Ni Chen, MD, PhD

      Affiliations

    • Laboratory of Pathology, State Key Laboratory of Biotherapy, West China Hospital, Chengdu, 610041 China
    • Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041 China
    • ,
  • Jing Gong, MD

      Affiliations

    • Laboratory of Pathology, State Key Laboratory of Biotherapy, West China Hospital, Chengdu, 610041 China
    • Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041 China
    • ,
  • Xueqin Chen, MD

      Affiliations

    • Laboratory of Pathology, State Key Laboratory of Biotherapy, West China Hospital, Chengdu, 610041 China
    • Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041 China
    • ,
  • Wentong Meng, MD

      Affiliations

    • Laboratory of Stem Cell Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041 China
    • ,
  • Ying Huang, MD

      Affiliations

    • Laboratory of Pathology, State Key Laboratory of Biotherapy, West China Hospital, Chengdu, 610041 China
    • Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041 China
    • ,
  • Fang Zhao, MD

      Affiliations

    • Department of Pathology, Haartman Institute, Haartmaninkatu 3, PL 21, 00014, University of Helsinki, Helsinki, Finland
    • ,
  • Lin Wang, MD, PhD

      Affiliations

    • Department of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    • ,
  • Qiao Zhou, MD, PhD

      Affiliations

    • Laboratory of Pathology, State Key Laboratory of Biotherapy, West China Hospital, Chengdu, 610041 China
    • Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041 China
    • Corresponding Author InformationCorresponding author.

Received 2 August 2008 ,Revised 2 December 2008 ,Accepted 3 December 2008.

References 

  1. Grossman D, Altieri DC. Drug resistance in melanoma: mechanisms, apoptosis, and new potential therapeutic targets. Cancer Metastasis Rev. 2001;20:3–11
  2. Soengas MS, Lowe SW. Apoptosis and melanoma chemoresistance. Oncogene. 2003;22:3138–3151
  3. Balch CM, Buzaid AC, Soong SJ, et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol. 2001;19:3635–3648
  4. Prasad ML, Patel S, Hoshaw-Woodard S, et al. Prognostic factors for malignant melanoma of the squamous mucosa of the head and neck. Am J Surg Pathol. 2002;26:883–892
  5. Patrick RJ, Fenske NA, Messina JL. Primary mucosal melanoma. J am Acad Dermatol. 2007;56:828–834
  6. Thompson LD, Wieneke JA, Miettinen M. Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic study of 115 cases with a proposed staging system. Am J Surg Pathol. 2003;27:594–611
  7. Salvesen GS, Abrams JM. Caspase activation—stepping on the gas or releasing the brakes? Lessons from humans and flies. Oncogene. 2004;23:2774–2784
  8. Shi Y. Caspase activation, inhibition, and reactivation: a mechanistic view. Protein Sci. 2004;13:1979–1987
  9. Schimmer AD. Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. Cancer Res. 2004;64:7183–7190
  10. Salvesen GS, Duckett CS. IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol. 2002;3:401–410
  11. Reed JC. Apoptosis-regulating proteins as targets for drug discovery. Trends Mol Med. 2001;7:314–319
  12. Vucic D, Stennicke HR, Pisabarro MT, Salvesen GS, Dixit VM. ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. Curr Biol. 2000;10:1359–1366
  13. Hussein MR, Haemel AK, Wood GS. Apoptosis and melanoma: molecular mechanisms. J Pathol. 2003;199:275–288
  14. Ivanov VN, Bhoumik A, Ronai Z. Death receptors and melanoma resistance to apoptosis. Oncogene. 2003;22:3152–3161
  15. Hersey P. Apoptosis and melanoma: how new insights are effecting the development of new therapies for melanoma. Curr Opin Oncol. 2006;18:189–196
  16. Bowen AR, Hanks AN, Allen SM, et al. Apoptosis regulators and responses in human melanocytic and keratinocytic cells. J Invest Dermatol. 2003;120:48–55
  17. Chawla-Sarkar M, Bae SI, Reu FJ, et al. Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis. Cell Death Differ. 2004;11:915–923
  18. Gong J, Chen N, Zhou Q, et al. Melanoma inhibitor of apoptosis protein is expressed differentially in melanoma and melanocytic naevus, but similarly in primary and metastatic melanomas. J Clin Pathol. 2005;58:1081–1085
  19. Emanuel PO, Phelps RG, Mudgil A, Shafir M, Burstein DE. Immunohistochemical detection of XIAP in melanoma. J Cutan Pathol. 2008;35:292–297
  20. Kluger HM, McCarthy MM, Alvero AB, et al. The X-linked inhibitor of apoptosis protein (XIAP) is up-regulated in metastatic melanoma, and XIAP cleavage by phenoxodiol is associated with Carboplatin sensitization. J Transl Med. 2007;5:6
  21. Chiodino C, Cesinaro AM, Ottani D, et al. Communication: expression of the novel inhibitor of apoptosis survivin in normal and neoplastic skin. J Invest Dermatol. 1999;113:415–418
  22. Gradilone A, Gazzaniga P, Ribuffo D, et al. Survivin, bcl-2, bax, and bcl-X gene expression in sentinel lymph nodes from melanoma patients. J Clin Oncol. 2003;21:306–312
  23. Takeuchi H, Morton DL, Elashoff D, Hoon DS. Survivin expression by metastatic melanoma predicts poor disease outcome in patients receiving adjuvant polyvalent vaccine. Int J Cancer. 2005;117:1032–1038
  24. Winnepenninckx V, Lazar V, Michiels S, et al. Gene expression profiling of primary cutaneous melanoma and clinical outcome. J Natl Cancer Inst. 2006;98:472–482
  25. Piras F, Murtas D, Minerba L, et al. Nuclear survivin is associated with disease recurrence and poor survival in patients with cutaneous malignant melanoma. Histopathology. 2007;50:835–842
  26. Chen N, Zhou Q. Constructing tissue microarrays without prefabricating recipient blocks: a novel approach. Am J Clin Pathol. 2005;124:103–107
  27. Kimura H, Weisz A, Ogura T, et al. Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide. J Biol Chem. 2001;276:2292–2298
  28. Liu X, Chen N, Wang X, et al. Apoptosis and proliferation markers in diffusely infiltrating astrocytomas: profiling of 17 molecules. J Neuropathol Exp Neurol. 2006;65:905–913
  29. Chen YB, Tu JJ, Kao J, Zhou XK, Chen YT. Survivin as a useful adjunct marker for the grading of papillary urothelial carcinoma. Arch Pathol Lab Med. 2008;132:224–231
  30. Shinohara ET, Gonzalez A, Massion PP, et al. Nuclear survivin predicts recurrence and poor survival in patients with resected nonsmall cell lung carcinoma. Cancer. 2005;103:1685–1692
  31. Yin W, Chen N, Zhang Y, et al. Survivin nuclear labeling index: a superior biomarker in superficial urothelial carcinoma of human urinary bladder. Mod Pathol. 2006;19:1487–1497
  32. Alonso SR, Ortiz P, Pollan M, et al. Progression in cutaneous malignant melanoma is associated with distinct expression profiles: a tissue microarray-based study. Am J Pathol. 2004;164:193–203
  33. Ding Y, Prieto VG, Zhang PS, et al. Nuclear expression of the antiapoptotic protein survivin in malignant melanoma. Cancer. 2006;106:1123–1129
  34. Fink D, Schlagbauer-Wadl H, Selzer E, et al. Elevated procaspase levels in human melanoma. Melanoma Res. 2001;11:385–393
  35. Persad R, Liu C, Wu TT, et al. Overexpression of caspase-3 in hepatocellular carcinomas. Mod Pathol. 2004;17:861–867

☆ Supported by grants to Dr Zhou from the Natural Science Foundation of China (30570692, 30221001, 30871383) and the Ministry of Education PhD Program Fund of China (20060610053), and to Dr. N Chen (30800637). Dr Meng was supported by the National Basic Research Program of China (2007CB947802).

☆☆ Dr Ni Chen and Dr Jing Gong contributed equally to this project.

PII: S0046-8177(08)00573-X

doi: 10.1016/j.humpath.2008.12.001

Human Pathology
Volume 40, Issue 7 , Pages 950-956 , July 2009

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