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Human Pathology
Volume 40, Issue 7
, Pages 957-964
, July 2009
p16, Ki-67, and BD ProEx™C immunostaining: a practical approach for diagnosis of cervical intraepithelial neoplasia
References
- . Human papillomavirus genotyping and p16INK4a expression in cervical intraepithelial neoplasia of adolescents. Mod Pathol. 2005;18:267–273
- . Detection of cervical high-grade squamous intraepithelial lesions from cytologic samples using a novel immunocytochemical assay (ProEx C). Cancer. 2006;108:494–500
- p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol. 2002;26:1389–1399
- . P16 expression in the female genital tract and its value in diagnosis. Adv Anat Pathol. 2006;13:8–15
- . Overexpression of p16 and p14ARF is associated with human papillomavirus infection in cervical squamous cell carcinoma and dysplasia. Pathol Int. 2002;52:375–383
- . Cyclin D–dependent kinases INK4 inhibitors and cancer. Biochim Biophys Acta. 2002;1602:73–87
- Immunohistochemical assessment of Ki-67 as prognostic cellular proliferation marker in anal canal carcinoma. J Exp Clin Cancer Res. 2000;19:471–475
- Identification of cervical cancer markers by cDNA and tissue microarrays. Cancer Res. 2003;63:1927–1935
- . Multiple biomarkers in molecular oncology. I. Molecular diagnostics applications in cervical cancer detection. Expert Rev Mol Diagn. 2007;7:117–131
- Gene expression profiles of primary HPV 16– and HPV 18–infected early stage cervical cancers and normal cervical epithelium: identification of novel candidate molecular markers for cervical cancer diagnosis and therapy. Virology. 2005;331:269–291
- . BD ProEx C: a sensitive and specific marker of HPV-associated squamous lesions of the cervix. Am J Surg Pathol. 2008;32:899–906
- Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer. 2001;92:276–284
- . Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol. 1998;153:1741–1748
- . Biomarker (ProEx™C, p16(INK4A), and MiB-1) distinction of high-grade squamous intraepithelial lesion from its mimics. Mod Pathol. 2008;21:1067–1074
- . The utility of p16(Ink4a) in discriminating between cervical intraepithelial neoplasia 1 and nonneoplastic equivocal lesions of the cervix. Arch Pathol Lab Med. 2008;132:795–799
- Evaluation of p16INK4a, minichromosome maintenance protein 2, DNA topoisomerase IIalpha, ProEX C, and p16INK4a/ProEX C in cervical squamous intraepithelial lesions. Hum Pathol. 2007;38:1335–1344
- . P16/Ki-67 immunostaining is useful in stratification of atypical metaplastic epithelium of the cervix. Clinical Medicine: Pathology. 2008;1:35–42[Electronic publication]
- . p16 and Ki-67 immunostaining in atypical immature squamous metaplasia of the uterine cervix: correlation with human papillomavirus detection. Arch Pathol Med. 2007;131:1343–1349
- Human papillomavirus (HPV) in atypical squamous cervical cytology: the Invader HPV Test as a new screening assay. J Clin Microbiol. 2008;46:869–875
- . P16 and Ki-67 immunostaining is a useful adjunct in the assessment of biopsies for HPV-associated anal intraepithelial neoplasia. Am J Surg Pathol. 2006;30:795–801
- . p16(INK4a) expression correlates with degree of cervical neoplasia: a comparison with Ki-67 expression and detection of high-risk HPV types. Mod Pathol. 2003;16:665–673
- p16 and MIB1 improve the sensitivity and specificity of the diagnosis of high grade squamous intraepithelial lesions: methodological issues in a report of 447 biopsies with consensus diagnosis and HPV HCII testing. Gynecol Oncol. 2007;107(1 Suppl 1):S233–S240[Electronic publication 2007 Sep 7]
- . Differentiating high-grade cervical intraepithelial lesion from atrophy in postmenopausal women using Ki-67, cyclin E, and p16 immunohistochemical analysis. J Low Genit Tract Dis. 2005;9:100–107
This study was presented in part at the USCAP annual meeting, Denver, CO, March 2008.
PII: S0046-8177(08)00577-7
doi: 10.1016/j.humpath.2008.12.005
© 2009 Elsevier Inc. All rights reserved.
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Human Pathology
Volume 40, Issue 7
, Pages 957-964
, July 2009
