Human Pathology
Volume 40, Issue 7 , Pages 942-949 , July 2009

Human papillomavirus profile of women in Belize City, Belize: correlation with cervical cytopathologic findings

  • Helen P. Cathro, MBChB, MPH

      Affiliations

    • Department of Pathology, PO Box 800214, University of Virginia Health System, Charlottesville, VA 22908, USA
    • Corresponding Author InformationCorresponding author.
  • ,
  • Theresa Loya, MD, MPH

      Affiliations

    • Los Angeles County Department of Public Health, Los Angeles, CA 90650, USA
  • ,
  • Frederick Dominguez, MD, MPH

      Affiliations

    • Los Angeles County Department of Public Health, Los Angeles, CA 90650, USA
  • ,
  • Susan L. Howe, MPH

      Affiliations

    • Clínica Maria Luisa Ortiz, Mulukuku, Nicaragua
  • ,
  • Renee Howell, PhD

      Affiliations

    • Digene Corporation, Gaithersburg, MD 20878, USA
  • ,
  • Kyle Orndorff, MS

      Affiliations

    • Digene Corporation, Gaithersburg, MD 20878, USA
  • ,
  • Jessica Moreno, MD

      Affiliations

    • Department of Obstetrics and Gynecology, University of Arizona, Tucson, AZ 85701, USA
  • ,
  • Elena Mendez, MD

      Affiliations

    • Hermosillo, 83000 Mexico
  • ,
  • Po Chu Fung, MBA

      Affiliations

    • Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
  • ,
  • Natalie L. Beer, MD

      Affiliations

    • Belize Ministry of Health, Belmopan, Belize
  • ,
  • Peter Allen, DDS, MPH

      Affiliations

    • Belize Ministry of Health, Belmopan, Belize
  • ,
  • Alba M. Sosa, MD

      Affiliations

    • Karl Heusner Memorial Hospital, Belize City, Belize
  • ,
  • Kelly K. Gurka, PhD, MPH

      Affiliations

    • Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
  • ,
  • Mark H. Stoler, MD

      Affiliations

    • Department of Pathology, PO Box 800214, University of Virginia Health System, Charlottesville, VA 22908, USA
  • ,
  • Henry F. Frierson Jr, MD

      Affiliations

    • Department of Pathology, PO Box 800214, University of Virginia Health System, Charlottesville, VA 22908, USA

Received 17 October 2008 ,Revised 22 December 2008 ,Accepted 30 December 2008.

References 

  1. Muy N. HPV and cervical cancer in the World 2007 report. Vaccine. 2007;25(Suppl 3):C1–C230
  2. Munoz N, Bosch FX, de Sanjose S, et al. The causal link between human papillomavirus and invasive cervical cancer: a population-based case-control study in Colombia and Spain. Int J Cancer. 1992;52:743–749
  3. Walboomers JM, Jacobs MV, Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189:12–19
  4. Munoz N, Bosch FX, de Sanjose S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003;348:518–527
  5. Schiffman MH, Bauer HM, Hoover RN, et al. Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia. J Natl Cancer Inst. 1993;85:958–964
  6. Trottier H, Mahmud S, Costa MC, et al. Human papillomavirus infections with multiple types and risk of cervical neoplasia. Cancer Epidemiol Biomarkers Prev. 2006;15:1274–1280
  7. Levi JE, Fernandes S, Tateno AF, et al. Presence of multiple human papillomavirus types in cervical samples from HIV-infected women. Gynecol Oncol. 2004;92:225–231
  8. Oliveira L. Patterns of genotype distribution in multiple human papillomavirus infections. Eur Soc Clin Microbiol. 2007;14:60–65
  9. Bosch FX, Manos MM, Munoz N, et al. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group. J Natl Cancer Inst. 1995;87:796–802
  10. Ferrera A, Velema JP, Figueroa M, et al. Human papillomavirus infection, cervical dysplasia and invasive cervical cancer in Honduras: a case-control study. Int J Cancer. 1999;82:799–803
  11. Giuliano AR, Papenfuss M, Abrahamsen M, et al. Human papillomavirus infection at the United States-Mexico border: implications for cervical cancer prevention and control. Cancer Epidemiol Biomarkers Prev. 2001;10:1129–1136
  12. Gonzalez-Losa Mdel R, Rosado-Lopez I, Valdez-Gonzalez N, Puerto-Solis M. High prevalence of human papillomavirus type 58 in Mexican colposcopy patients. J Clin Virol. 2004;29:202–205
  13. Herrero R, Hildesheim A, Bratti C, et al. Population-based study of human papillomavirus infection and cervical neoplasia in rural Costa Rica. J Natl Cancer Inst. 2000;92:464–474
  14. Herrero R, Castle PE, Schiffman M, et al. Epidemiologic profile of type-specific human papillomavirus infection and cervical neoplasia in Guanacaste, Costa Rica. J Infect Dis. 2005;191:1796–1807
  15. Lazcano-Ponce E, Herrero R, Munoz N, et al. Epidemiology of HPV infection among Mexican women with normal cervical cytology. Int J Cancer. 2001;91:412–420
  16. Torroella-Kouri M, Morsberger S, Carrillo A, et al. HPV prevalence among Mexican women with neoplastic and normal cervixes. Gynecol Oncol. 1998;70:115–120
  17. Solomon D, Davey D, Kurman R, et al. The 2001 Bethesda System: terminology for reporting results of cervical cytology. Jama. 2002;287:2114–2119
  18. Stokes ME, Davis CS, Koch GG. Categorical data analysis using the SAS system. 2nd ed. Cary, NC: SAS Institute; 2000;
  19. In:  Doll R,  Payne P,  Waterhouse J editor. Cancer Incidence in Five Continents: a Technical Report, (Vol I). Berlin: Springer-Verlag; 1966;(for UICC)
  20. Clifford GM, Gallus S, Herrero R, et al. Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: a pooled analysis. Lancet. 2005;366:991–998
  21. Clifford GM, Smith JS, Aguado T, Franceschi S. Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis. Br J Cancer. 2003;89:101–105
  22. Franceschi S, Clifford GM. Re: a study of the impact of adding HPV types to cervical cancer screening and triage tests. J Natl Cancer Inst. 2005;97:938–939author reply 939-41
  23. Smith JS, Lindsay L, Hoots B, et al. Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update. Int J Cancer. 2007;121:621–632
  24. Clifford GM, Smith JS, Plummer M, Munoz N, Franceschi S. Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis. Br J Cancer. 2003;88:63–73
  25. Munoz N, Bosch FX, Castellsague X, et al. Against which human papillomavirus types shall we vaccinate and screen? The international perspective. Int J Cancer. 2004;111:278–285
  26. van der Graaf Y, Molijn A, Doornewaard H, Quint W, van Doorn LJ, van den Tweel J. Human papillomavirus and the long-term risk of cervical neoplasia. Am J Epidemiol. 2002;156:158–164
  27. Gravitt PE, Kovacic MB, Herrero R, et al. High load for most high risk human papillomavirus genotypes is associated with prevalent cervical cancer precursors but only HPV16 load predicts the development of incident disease. Int J Cancer. 2007;121:2787–2793
  28. Gravitt PE, van Doorn LJ, Quint W, et al. Human papillomavirus (HPV) genotyping using paired exfoliated cervicovaginal cells and paraffin-embedded tissues to highlight difficulties in attributing HPV types to specific lesions. J Clin Microbiol. 2007;45:3245–3250
  29. Franco EL, Harper DM. Vaccination against human papillomavirus infection: a new paradigm in cervical cancer control. Vaccine. 2005;23:2388–2394
  30. Bosch FX, Castellsague X, de Sanjose S. HPV and cervical cancer: screening or vaccination?. Br J Cancer. 2008;98:15–21
  31. Harper DM, Franco EL, Wheeler CM, et al. Sustained efficacy up to 4.5 years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and 18: follow-up from a randomised control trial. Lancet. 2006;367:1247–1255
  32. de Sanjose S, Diaz M, Castellsague X, Clifford G, et al. Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a metaanalysis. Lancet. 2007;7:453–459

 The study was sponsored by The American Cancer Society (Oklahoma City, OK, USA); The Belizean Ministry of Health (Belmopan, Belize); The Department of Pathology, the University of Virginia at Charlottesville (Charlottesville, VA, USA); Digene Corporation (Gaithersburg, MD, USA).

PII: S0046-8177(09)00002-1

doi: 10.1016/j.humpath.2008.12.015

Human Pathology
Volume 40, Issue 7 , Pages 942-949 , July 2009