Human Pathology
Volume 40, Issue 12 , Pages 1693-1698 , December 2009

A pathological reassessment of organ-confined, Gleason score 6 prostatic adenocarcinomas that progress after radical prostatectomy

  • Hiroshi Miyamoto, MD, PhD

      Affiliations

    • The Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    • ,
  • David J. Hernandez, MD

      Affiliations

    • The Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    • ,
  • Jonathan I. Epstein, MD

      Affiliations

    • The Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    • The Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    • The Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    • Corresponding Author InformationCorresponding author. Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA.

Received 4 March 2009 ,Revised 27 April 2009 ,Accepted 5 May 2009.

References 

  1. Lerner SE, Blute ML, Bergstralh EJ, Bostwick DG, Eickholt JT, Zincke H. Analysis of risk factors for progression in patients with pathologically confined prostate cancers after radical retropubic prostatectomy. J Urol. 1996;156:137–143
  2. Han M, Partin AW, Zahurak M, Piantadosi S, Epstein JI, Walsh PC. Biochemical (prostate specific antigen) recurrence probability following radical prostatectomy for clinically localized prostate cancer. J Urol. 2003;169:517–523
  3. Epstein JI, Walsh PC, Carmichael M, Brendler CB. Pathologic and clinical findings to predict tumor extent of nonpalpable (stage T1c) prostate cancer. JAMA. 1994;271:368–374
  4. Ramos CG, Roehl KA, Antenor JA, Humphrey PA, Catalona WJ. Percent carcinoma in prostatectomy specimen is associated with risk of recurrence after radical prostatectomy in patients with pathologically organ confined prostate cancer. J Urol. 2004;172:137–140
  5. Merrill MM, Lane BR, Reuther AM, Zhou M, Magi-Galluzzi C, Klein EA. Tumor volume does not predict for biochemical recurrence after radical prostatectomy in patients with surgical Gleason score 6 or less prostate cancer. Urology. 2007;70:294–298
  6. Hernandez DJ, Nielsen ME, Han M, et al. Natural history of pathologically organ-confined (pT2), Gleason score 6 or less, prostate cancer after radical prostatectomy. Urology. 2008;72:172–176
  7. Yoon GS, Wang W, Osunkoya AO, Lane Z, Partin AW, Epstein JI. Residual tumor potentially left behind after local ablation therapy in prostate adenocarcinoma. J Urol. 2008;179:2203–2206[discussion 2206]
  8. Epstein JI, Allsbrook WC, Amin MB, Egevad LL, ISUP Grading Committee . The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. Am J Surg Pathol. 2005;29:1228–1242
  9. Latour M, Amin MB, Billis A, et al. Grading of invasive cribriform carcinoma on prostate needle biopsy: an interobserver study among experts in genitourinary pathology. Am J Surg Pathol. 2008;32:1532–1539
  10. Lotan TL, Epstein JI. Gleason grading of prostatic adenocarcinoma with glomeruloid features on needle biopsy. Hum Pathol. 2009;40:471–477
  11. Pan CC, Potter SR, Partin AW, Epstein JI. The prognostic significance of tertiary Gleason patterns of higher grade in radical prostatectomy specimens: a proposal to modify the Gleason grading system. Am J Surg Pathol. 2000;24:563–569
  12. Evans AJ, Henry PC, Van der Kwast TH, et al. Interobserver variability between expert urologic pathologists for extraprostatic extension and surgical margin status in radical prostatectomy specimens. Am J Surg Pathol. 2008;32:1503–1512
  13. Chuang AY, Nielsen ME, Hernandez DJ, Walsh PC, Epstein JI. The significance of positive surgical margin in areas of capsular incision in otherwise organ confined disease at radical prostatectomy. J Urol. 2007;178:1306–1310

PII: S0046-8177(09)00163-4

doi: 10.1016/j.humpath.2009.05.001

Human Pathology
Volume 40, Issue 12 , Pages 1693-1698 , December 2009

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