Human Pathology
Volume 40, Issue 12 , Pages 1706-1714 , December 2009

Metallothionein overexpression and its prognostic relevance in intrahepatic cholangiocarcinoma and extrahepatic hilar cholangiocarcinoma (Klatskin tumors)

  • Klaus Jürgen Schmitz, MD

      Affiliations

    • Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg-Essen, D-45147 Essen, Germany
    • Corresponding Author InformationCorresponding author.
    • ,
  • Hauke Lang, MD

      Affiliations

    • Department of General and Abdominal Surgery, Johannes Gutenberg University Hospital Mainz, Mainz, Germany
    • ,
  • Gernot Kaiser, MD

      Affiliations

    • Department of General, Visceral and Transplantation Surgery, University Hospital of Essen, University of Duisburg-Essen, Germany
    • ,
  • Jeremias Wohlschlaeger, MD

      Affiliations

    • Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg-Essen, D-45147 Essen, Germany
    • ,
  • Georgios Charalambos Sotiropoulos, MD

      Affiliations

    • Department of General and Abdominal Surgery, Johannes Gutenberg University Hospital Mainz, Mainz, Germany
    • ,
  • Hideo Andreas Baba, MD

      Affiliations

    • Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg-Essen, D-45147 Essen, Germany
    • Member of the West German Cancer Centre Essen (WTZE).
    • ,
  • Bharat Jasani, MD

      Affiliations

    • Department of Pathology, University of Wales College of Medicine, Cardiff, UK
    • ,
  • Kurt Werner Schmid, MD

      Affiliations

    • Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg-Essen, D-45147 Essen, Germany
    • Member of the West German Cancer Centre Essen (WTZE).

Received 24 November 2008 ,Revised 12 January 2009 ,Accepted 31 January 2009.

References 

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  2. Klatskin G. Adenocarcinoma of the hepatic duct at its bifurcation within the porta hepatis: an unusual tumor with distinct clinical and pathological features. Am J Med. 1965;38:241–256
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  8. Murphy BJ, Kimura T, Sato BG, Shi Y, Andrews GK. Metallothionein induction by hypoxia involves cooperative interactions between metal-responsive transcription factor-1 and hypoxia-inducible transcription factor-1alpha. Mol Cancer Res. 2008;6:483–490
  9. Chubatsu LS, Meneghini R. Metallothionein protects DNA from oxidative damage. Biochem J. 1993;291(Pt 1):193–198
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  11. Jasani B, Schmid KW. Significance of metallothionein overexpression in human tumours. Histopathology. 1997;31:211–214
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  15. Schmitz KJ, Lang H, Wohlschlaeger J, et al. Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma. Virchows Arch. 2007;450:135–141
  16. Lang H, Sotiropoulos GC, Fruhauf NR, et al. Extended hepatectomy for intrahepatic cholangiocellular carcinoma (ICC): when is it worthwhile? Single center experience with 27 resections in 50 patients over a 5-year period. Ann Surg. 2005;241:134–143
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  24. Cherian MG, Apostolova MD. Nuclear localization of metallothionein during cell proliferation and differentiation. Cell Mol Biol (Noisy -le-grand). 2000;46:347–356
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  27. Jarnagin WR, Bowne W, Klimstra DS, et al. Papillary phenotype confers improved survival after resection of hilar cholangiocarcinoma. Ann Surg. 2005;241:703–712
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PII: S0046-8177(09)00166-X

doi: 10.1016/j.humpath.2009.01.026

Human Pathology
Volume 40, Issue 12 , Pages 1706-1714 , December 2009

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