Human Pathology
Volume 40, Issue 12 , Pages 1679-1685 , December 2009

Down-regulation of ephrin-A5, a gene product of normal cartilage, in chondrosarcoma

  • Thomas Kalinski, MD

      Affiliations

    • Department of Pathology, Otto-von-Guericke-University, D-39120 Magdeburg, Germany
    • Corresponding Author InformationCorresponding author.
    • ,
  • Albrecht Röpke, PhD

      Affiliations

    • Department of Human Genetics, Westfalian Wilhelms-University, D-48149 Münster, Germany
    • ,
  • Saadettin Sel, MD

      Affiliations

    • Department of Ophthalmology, Martin-Luther-University, D-06120 Halle, Germany
    • ,
  • Irina Kouznetsova, PhD

      Affiliations

    • Department of Molecular Biology and Medical Chemistry, Otto-von-Guericke-University, D-39120 Magdeburg, Germany
    • ,
  • Martin Röpke, MD

      Affiliations

    • Department of Orthopedics, Otto-von-Guericke-University, D-39120 Magdeburg, Germany
    • ,
  • Albert Roessner, MD

      Affiliations

    • Department of Pathology, Otto-von-Guericke-University, D-39120 Magdeburg, Germany

Received 29 October 2008 ,Revised 24 February 2009 ,Accepted 21 March 2009.

References 

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  2. Zhang J, Hughes S. Role of the ephrin and Eph receptor tyrosine kinase families in angiogenesis and development of the cardiovascular system. J Pathol. 2006;208:453–461
  3. Davy A, Soriano P. Ephrin signaling in vivo: look both ways. Dev Dyn. 2005;232:1–10
  4. Himanen JP, Chumley MJ, Lackmann M, et al. Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling. Nat Neurosci. 2004;7:501–509
  5. Davy A, Gale NW, Murray EW, et al. Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion. Genes Dev. 1999;13:3125–3135
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  11. Kalinski T, Krueger S, Pelz AF, et al. Establishment and characterization of the permanent human cell line C3842 derived from a secondary chondrosarcoma in Ollier's disease. Virchows Arch. 2005;446:287–299
  12. Kalinski T, Krueger S, Sel S, Werner K, Ropke M, Roessner A. Differential expression of VEGF-A and angiopoietins in cartilage tumors and regulation by interleukin-1beta. Cancer. 2006;106:2028–2038
  13. Krueger S, Kalinski T, Hundertmark T, et al. Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer. J Pathol. 2005;207:32–42
  14. Röpke A, Buhtz P, Böhm M, et al. Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer. Oncogene. 2005;24:6667–6675
  15. Fox BP, Kandpal RP. Invasiveness of breast carcinoma cells and transcript profile: Eph receptors and ephrin ligands as molecular markers of potential diagnostic and prognostic application. Biochem Biophys Res Commun. 2004;318:882–892
  16. Herath NI, Spanevello MD, Sabesan S, et al. Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival. BMC Cancer. 2006;6:144
  17. Varelias A, Koblar SA, Cowled PA, Carter CD, Clayer M. Human osteosarcoma expresses specific ephrin profiles: implications for tumorigenicity and prognosis. Cancer. 2002;95:862–869
  18. Shi H, Guo J, Duff DJ, et al. Discovery of novel epigenetic markers in non-Hodgkin's lymphoma. Carcinogenesis. 2007;28:60–70
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PII: S0046-8177(09)00169-5

doi: 10.1016/j.humpath.2009.03.024

Human Pathology
Volume 40, Issue 12 , Pages 1679-1685 , December 2009

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