Human Pathology
Volume 40, Issue 12 , Pages 1686-1692 , December 2009

Reg IV expression and clinicopathologic features of gallbladder carcinoma

  • Hidehiko Tamura, MD, PhD

      Affiliations

    • Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
    • ,
  • Masayuki Ohtsuka, MD, PhD

      Affiliations

    • Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
    • Corresponding Author InformationCorresponding author.
    • ,
  • Mitsutsune Washiro, MD, PhD

      Affiliations

    • Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
    • ,
  • Fumio Kimura, MD, PhD

      Affiliations

    • Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
    • ,
  • Hiroaki Shimizu, MD, PhD

      Affiliations

    • Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
    • ,
  • Hiroyuki Yoshidome, MD, PhD

      Affiliations

    • Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
    • ,
  • Atsushi Kato, MD, PhD

      Affiliations

    • Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
    • ,
  • Naohiko Seki, PhD

      Affiliations

    • Department of Functional Genomics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
    • ,
  • Masaru Miyazaki, MD, PhD

      Affiliations

    • Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan

Received 19 January 2009 ,Revised 2 June 2009 ,Accepted 11 June 2009.

References 

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  2. Oue N, Mitani Y, Aung PP, et al. Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma. J Pathol. 2005;207:185–198
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  16. Wu XS, Akiyama Y, Igari T, et al. Expression of homeodomain protein CDX2 in gallbladder carcinomas. J Cancer Res Clin Oncol. 2005;131:271–278
  17. Silberg DG, Swain GP, Suh ER, Traber PG. Cdx1 and cdx2 expression during intestinal development. Gastroenterology. 2000;119:961–971
  18. Nakata K, Nagai E, Ohuchida K, et al. REG4 is associated with carcinogenesis in the ‘intestinal’ pathway of intraductal papillary mucinous neoplasms. Mod Pathol. 2009;22:460–468
  19. In:  Sobin LH,  Wittekind Ch editor. International Union Against Cancer: TNM classification of malignant tumors. 6th ed.. New York: Wiley-Liss; 2002;
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  21. Mitani Y, Oue N, Matsumura S, et al. Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. Oncogene. 2007;26:4383–4393
  22. Matsumoto K, Mizoshita T, Tsukamoto T, et al. Cdx2 expression in pancreatic tumors: relationship with prognosis of invasive ductal carcinomas. Oncol Rep. 2004;12:1239–1243
  23. Adsay NV, Merati K, Basturk O, et al. Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms. Delineation of an “intestinal” pathway of carcinogenesis in the pancreas. Am J Surg Pathol. 2004;28:839–848
  24. de Aretxabala X, Roa I, Burgos L. Gallbladder cancer, management of early tumors. Hepatogastroenterology. 1999;46:1547–1551
  25. Wistuba II, Sugio K, Hung J, et al. Allele-specific mutations involved in the pathogenesis of endemic gallbladder carcinoma in Chile. Cancer Res. 1995;55:2511–2515
  26. Bishnupuri KS, Luo Q, Murmu N, Houchen CW, Anant S, Dieckgraefe BK. Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon carcinomas. Gastroenterology. 2006;130:137–149
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  29. Gore RM, Yaghmai V, Newmark GM, Berlin JW, Miller FH. Imaging benign and malignant disease of the gallbladder. Radiol Clin North Am. 2002;40:1307–1323
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PII: S0046-8177(09)00206-8

doi: 10.1016/j.humpath.2009.06.001

Human Pathology
Volume 40, Issue 12 , Pages 1686-1692 , December 2009

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