Human Pathology
Volume 41, Issue 1 , Pages 48-58 , January 2010

Frequent epigenetic inactivation of the receptor tyrosine kinase EphA5 by promoter methylation in human breast cancer

  • De-Yuan Fu, MD

      Affiliations

    • Breast Cancer Institute, Cancer Hospital, Department of Oncology, Shanghai Medical College, Institutes of Biomedical Science, Fudan University, Shanghai 200032, PR China
    • Department of Breast Surgery, Subei People's Hospital of Jiangsu Province, Yangzhou, 225001, China
    • These authors contributed equally to this work.
    • ,
  • Zhi-Min Wang, PhD

      Affiliations

    • Chinese National Human Genome Center at Shanghai, Shanghai, 201203, PR China
    • These authors contributed equally to this work.
    • ,
  • Bei-Lan Wang, BS

      Affiliations

    • Chinese National Human Genome Center at Shanghai, Shanghai, 201203, PR China
    • ,
  • Li Chen, MS

      Affiliations

    • Breast Cancer Institute, Cancer Hospital, Department of Oncology, Shanghai Medical College, Institutes of Biomedical Science, Fudan University, Shanghai 200032, PR China
    • ,
  • Wen-Tao Yang, MD

      Affiliations

    • Department of Pathology, Cancer Hospital, Department of Oncology, Shanghai Medical College, Institutes of Biomedical Science, Fudan University, Shanghai 200032, PR China
    • ,
  • Zhen-Zhou Shen, MD

      Affiliations

    • Breast Cancer Institute, Cancer Hospital, Department of Oncology, Shanghai Medical College, Institutes of Biomedical Science, Fudan University, Shanghai 200032, PR China
    • ,
  • Wei Huang, PhD

      Affiliations

    • Chinese National Human Genome Center at Shanghai, Shanghai, 201203, PR China
    • Corresponding Author InformationCorresponding authors. Zhi-Min Shao is to be contacted at Department of Breast Surgery, Cancer Hospital/Cancer Institute, Breast Cancer Institute, Fudan University, Shanghai 200032, PR China. Wei Huang, Chinese National Human Genome Center at Shanghai, Shanghai 201203, PR China.
    • ,
  • Zhi-Ming Shao, MD

      Affiliations

    • Breast Cancer Institute, Cancer Hospital, Department of Oncology, Shanghai Medical College, Institutes of Biomedical Science, Fudan University, Shanghai 200032, PR China
    • Corresponding Author InformationCorresponding authors. Zhi-Min Shao is to be contacted at Department of Breast Surgery, Cancer Hospital/Cancer Institute, Breast Cancer Institute, Fudan University, Shanghai 200032, PR China. Wei Huang, Chinese National Human Genome Center at Shanghai, Shanghai 201203, PR China.

Received 10 March 2009 ,Revised 3 June 2009 ,Accepted 11 June 2009.

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☆ This research was supported in part by the grants from the National Basic Research Program of China (2006CB910501), National Natural Science Foundation of China (30371580, 30572109), and Shanghai Science and Technology Committee (03J14019, 06DJ14004, 06DZ19504).

PII: S0046-8177(09)00226-3

doi: 10.1016/j.humpath.2009.06.007

Human Pathology
Volume 41, Issue 1 , Pages 48-58 , January 2010

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