Human Pathology
Volume 41, Issue 2 , Pages 214-222, February 2010

N-myc downstream regulated gene-1/Cap43 may play an important role in malignant progression of prostate cancer, in its close association with E-cadherin☆☆☆

  • YooHyun Song, MD

      Affiliations

    • Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • ,
  • Yoshinao Oda, MD, PhD

      Affiliations

    • Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • Corresponding Author InformationCorresponding author. Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
    • ,
  • Mikifumi Hori, MD, PhD

      Affiliations

    • Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • ,
  • Kentaro Kuroiwa, MD, PhD

      Affiliations

    • Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • ,
  • Mayumi Ono, PhD

      Affiliations

    • Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • ,
  • Fumihito Hosoi, MS

      Affiliations

    • Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • ,
  • Yuji Basaki, PhD

      Affiliations

    • Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • ,
  • Shoji Tokunaga, PhD

      Affiliations

    • Department of Medical Informatics, Kyushu University Hospital, Fukuoka 812-8582, Japan
    • ,
  • Michihiko Kuwano, MD, PhD

      Affiliations

    • Division of Innovative Anticancer Diagnosis and Therapeutics, Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka 812-8582, Japan
    • ,
  • Seiji Naito, MD, PhD

      Affiliations

    • Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • ,
  • Masazumi Tsuneyoshi, MD, PhD

      Affiliations

    • Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan

Received 22 April 2009; received in revised form 17 July 2009; accepted 22 July 2009. published online 05 October 2009.

Summary 

N-myc downstream regulated gene-1 (NDRG1)/Cap43 plays an important role in tumor progression and metastases in many kinds of cancers. Recently, it was reported that NDRG1/Cap43 is involved in the aggressiveness of prostate cancer and also that its expression is associated with the expression of E-cadherin in prostate carcinoma cell lines. In the current study, to elucidate the functional and pathologic roles of NDRG1/Cap43 in prostate cancer, we investigated whether the expression of NDRG1/Cap43 is associated with the clinicopathologic parameters of prostate cancer or E-cadherin expression. NDRG1/Cap43 expression and E-cadherin expression were examined immunohistochemically in 148 patients with prostate cancer. We investigated the correlation between membranous or cytoplasmic expression of NDRG1/Cap43 and E-cadherin and evaluated the prognostic or clinicopathologic significance of the expression of NDRG1/Cap43. The patients with decreased NDRG1/Cap43 membranous expression showed significantly lower disease-free survival rates compared with the patients with preserved NDRG1/Cap43 membranous expression. Decreased membranous and high cytoplasmic NDRG1/Cap43 expression was also correlated with a higher Gleason score. A significant correlation was observed between NDRG1/Cap43 membranous expression and E-cadherin membranous expression (r = 0.7130; P < .0001) and between NDRG1/Cap43 cytoplasmic expression and E-cadherin cytoplasmic expression (r = 0.5847; P < .0001). Decreased NDRG1/Cap43 membranous expression had a significant impact on patient disease-free survival in multivariate analysis (P = .0175). NDRG1/Cap43 could be a novel marker for malignant progression and poor prognosis in prostate cancer, plausibly in its close association with the down-regulation of E-cadherin expression.

Keywords: NDRG1/Cap43, Prostate, Carcinogenesis, E-cadherin, Prognosis

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☆ This work was supported by a Grant-in-Aid for Scientific Research (B) from the Japan Society for the Promotion of Science (21390107), Tokyo, Japan. The English used in this manuscript was revised by KN International Inc (3 Golf Center, Suite no. 407, Hoffman Estates, IL 60169).

☆☆ The authors declare no disclosures or conflicts of interest.

PII: S0046-8177(09)00275-5

doi:10.1016/j.humpath.2009.07.011

Human Pathology
Volume 41, Issue 2 , Pages 214-222, February 2010

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