Human Pathology
Volume 41, Issue 2 , Pages 214-222 , February 2010

N-myc downstream regulated gene-1/Cap43 may play an important role in malignant progression of prostate cancer, in its close association with E-cadherin

  • YooHyun Song, MD

      Affiliations

    • Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • ,
  • Yoshinao Oda, MD, PhD

      Affiliations

    • Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • Corresponding Author InformationCorresponding author. Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
    • ,
  • Mikifumi Hori, MD, PhD

      Affiliations

    • Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • ,
  • Kentaro Kuroiwa, MD, PhD

      Affiliations

    • Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • ,
  • Mayumi Ono, PhD

      Affiliations

    • Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • ,
  • Fumihito Hosoi, MS

      Affiliations

    • Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • ,
  • Yuji Basaki, PhD

      Affiliations

    • Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • ,
  • Shoji Tokunaga, PhD

      Affiliations

    • Department of Medical Informatics, Kyushu University Hospital, Fukuoka 812-8582, Japan
    • ,
  • Michihiko Kuwano, MD, PhD

      Affiliations

    • Division of Innovative Anticancer Diagnosis and Therapeutics, Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka 812-8582, Japan
    • ,
  • Seiji Naito, MD, PhD

      Affiliations

    • Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • ,
  • Masazumi Tsuneyoshi, MD, PhD

      Affiliations

    • Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan

Received 22 April 2009 ,Revised 17 July 2009 ,Accepted 22 July 2009.

References 

  1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin. 2007;57:43–66
  2. Han M, Partin AW, Zahurak M, Piantadosi S, Epstein JI, Walsh PC. Biochemical (prostate specific antigen) recurrence probability following radical prostatectomy for clinically localized prostate cancer. J Urol. 2003;169:517–523
  3. Zhou D, Salnikow K, Costa M. Cap43, a novel gene specifically induced by Ni2+ compounds. Cancer Res. 1998;58:2182–2189
  4. van Belzen N, Dinjens WN, Diesveld MP, et al. A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms. Lab Invest. 1997;77:85–92
  5. Taketomi Y, Sugiki T, Saito T, et al. Identification of NDRG1 as an early inducible gene during in vitro maturation of cultured mast cells. Biochem Biophys Res Commun. 2003;306:339–346
  6. Piquemal D, Joulia D, Balaguer P, Basset A, Marti J, Commes T. Differential expression of the RTP/Drg1/Ndr1 gene product in proliferating and growth arrested cells. Biochim Biophys Acta. 1999;1450:364–373
  7. Kurdistani SK, Arizti P, Reimer CL, Sugrue MM, Aaronson SA, Lee SW. Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage. Cancer Res. 1998;58:4439–4444
  8. Guan RJ, Ford HL, Fu Y, Li Y, Shaw LM, Pardee AB. Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer. Cancer Res. 2000;60:749–755
  9. Bandyopadhyay S, Pai SK, Gross SC, et al. The Drg-1 gene suppresses tumor metastasis in prostate cancer. Cancer Res. 2003;63:1731–1736
  10. Bandyopadhyay S, Pai SK, Hirota S, et al. PTEN up-regulates the tumor metastasis suppressor gene Drg-1 in prostate and breast cancer. Cancer Res. 2004;64:7655–7660
  11. Cangul H. Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers. BMC Genet. 2004;5:27
  12. Cangul H, Salnikow K, Yee H, Zagzag D, Commes T, Costa M. Enhanced expression of a novel protein in human cancer cells: a potential aid to cancer diagnosis. Cell Biol Toxicol. 2002;18:87–96
  13. Chen J, Li S, Yang Z, Lu G, Hu H. Correlation between NDRG1 and PTEN expression in endometrial carcinoma. Cancer Sci. 2008;99:706–710
  14. Wang Z, Wang F, Wang WQ, et al. Correlation of N-myc downstream-regulated gene 1 overexpression with progressive growth of colorectal neoplasm. World J Gastroenterol. 2004;10:550–554
  15. Chua MS, Sun H, Cheung ST, et al. Overexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinoma. Mod Pathol. 2007;20:76–83
  16. Maruyama Y, Ono M, Kawahara A, et al. Tumor growth suppression in pancreatic cancer by a putative metastasis suppressor gene Cap43/NDRG1/Drg-1 through modulation of angiogenesis. Cancer Res. 2006;66:6233–6242
  17. Angst E, Sibold S, Tiffon C, et al. Cellular differentiation determines the expression of the hypoxia-inducible protein NDRG1 in pancreatic cancer. Br J Cancer. 2006;95:307–313
  18. Fotovati A, Fujii T, Yamaguchi M, et al. 17Beta-estradiol induces down-regulation of Cap43/NDRG1/Drg-1, a putative differentiation-related and metastasis suppressor gene, in human breast cancer cells. Clin Cancer Res. 2006;12:3010–3018
  19. Koshiji M, Kumamoto K, Morimura K, et al. Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity. World J Gastroenterol. 2007;13:2803–2810
  20. Nishio S, Ushijima K, Tsuda N, et al. Cap43/NDRG1/Drg-1 is a molecular target for angiogenesis and a prognostic indicator in cervical adenocarcinoma. Cancer Lett. 2008;264:36–43
  21. Umbas R, Isaacs WB, Bringuier PP, et al. Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer Res. 1994;54:3929–3933
  22. Morton RA, Ewing CM, Nagafuchi A, Tsukita S, Isaacs WB. Reduction of E-cadherin levels and deletion of the alpha-catenin gene in human prostate cancer cells. Cancer Res. 1993;53:3585–3590
  23. De Marzo AM, Knudsen B, Chan-Tack K, Epstein JI. E-cadherin expression as a marker of tumor aggressiveness in routinely processed radical prostatectomy specimens. Urology. 1999;53:707–713
  24. Lachat P, Shaw P, Gebhard S, van Belzen N, Chaubert P, Bosman FT. Expression of NDRG1, a differentiation-related gene, in human tissues. Histochem Cell Biol. 2002;118:399–408
  25. Stein S, Thomas EK, Herzog B, et al. NDRG1 is necessary for p53-dependent apoptosis. J Biol Chem. 2004;279:48930–48940
  26. Kachhap SK, Faith D, Qian DZ, et al. The N-myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin. PLoS ONE. 2007;2:e844
  27. Koksal IT, Ozcan F, Kilicaslan I, Tefekli A. Expression of E-cadherin in prostate cancer in formalin-fixed, paraffin-embedded tissues: correlation with pathological features. Pathology. 2002;34:233–238
  28. Rubin MA, Mucci NR, Figurski J, Fecko A, Pienta KJ, Day ML. E-cadherin expression in prostate cancer: a broad survey using high-density tissue microarray technology. Hum Pathol. 2001;32:690–697
  29. Kuczyk M, Serth J, Machtens S, et al. Expression of E-cadherin in primary prostate cancer: correlation with clinical features. Br J Urol. 1998;81:406–412
  30. Caruso RP, Levinson B, Melamed J, et al. Altered N-myc downstream-regulated gene 1 protein expression in African-American compared with Caucasian prostate cancer patients. Clin Cancer Res. 2004;10(1 Pt 1):222–227

☆ This work was supported by a Grant-in-Aid for Scientific Research (B) from the Japan Society for the Promotion of Science (21390107), Tokyo, Japan. The English used in this manuscript was revised by KN International Inc (3 Golf Center, Suite no. 407, Hoffman Estates, IL 60169).

☆☆ The authors declare no disclosures or conflicts of interest.

PII: S0046-8177(09)00275-5

doi: 10.1016/j.humpath.2009.07.011

Human Pathology
Volume 41, Issue 2 , Pages 214-222 , February 2010

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