Human Pathology
Volume 41, Issue 2 , Pages 163-171 , February 2010

Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 30 pure and mixed cases

  • Matthew J. Wasco, MD

      Affiliations

    • Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    • ,
  • Stephanie Daignault, MS

      Affiliations

    • Department of Urology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    • Department of Biostatistics, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    • ,
  • Deborah Bradley, MD

      Affiliations

    • Department of Oncology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    • ,
  • Rajal B. Shah, MD

      Affiliations

    • Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    • Department of Urology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    • Corresponding Author InformationCorresponding author. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Received 20 May 2009 ,Revised 22 July 2009 ,Accepted 23 July 2009.

References 

  1. Lopez-Beltran A, Sauter G, Gasser T, et al. Infiltrating urothelial carcinoma. In:  Eble JN, et al. editor. World Health Organization classification of tumours: pathology and genetics of tumours of the urinary system and male genital organs. Lyon, France: IARC Press; 2004;p. 93–109
  2. Cheng L, Lopez-Beltran A, MacLennan GT, Montironi R, Bostwick DG. Neoplasms of the urinary bladder. In:  Cheng L,  Bostwick DG editor. Urologic surgical pathology, 2nd ed. London, UK: Elsevier; 2008;p. 260–351
  3. Volmar KE, Chan TY, De Marzo AM, Epstein JI. Florid von Brunn nests mimicking urothelial carcinoma: a morphologic and immunohistochemical comparison to the nested variant of urothelial carcinoma. Am J Surg Pathol. 2003;27:1243–1252
  4. Dhall D, Al-Almadie H, Olgac S. Nested variant of urothelial carcinoma. Arch Pathol Lab Med. 2007;131:1725–1727
  5. Murphy WM, Deana DG. The nested variant of transitional cell carcinoma: a neoplasm resembling proliferation of Brunn's nests. Mod Pathol. 1992;5:240–243
  6. Pusztaszeri M, Hauser J, Iselin C, Egger JF, Pelte MF. Urothelial carcinoma “nested variant” of renal pelvis and ureter. Urology. 2007;69:778.e15-7
  7. Holmäng S, Johansson SL. The nested variant of transitional cell carcinoma—a rare neoplasm with poor prognosis. Scand J Urol Nephrol. 2001;35:102–105
  8. Liedberg F, Chebil G, Davidsson T, Gadaleanu V, Grabe M, Mansson W. The nested variant of urothelial carcinoma: a rare but important bladder neoplasm with aggressive behavior. Three case reports and a review of the literature. Urol Oncol. 2003;21:7–9
  9. Drew PA, Furman J, Civantos F, Murphy WM. The nested variant of transitional cell carcinoma: an aggressive neoplasm with innocuous histology. Mod Pathol. 1996;9:989–994
  10. Talbert ML, Young RH. Carcinomas of the urinary bladder with deceptively benign-appearing foci. A report of three cases. Am J Surg Pathol. 1989;13:374–381
  11. Stern JB. Unusual benign bladder tumor of Brunn nest origin. Urology. 1979;14:288–289
  12. Billerey C, Martin L, Bittard H, Adessi GL, Carbillet JP. The nested variant of urothelial carcinoma of the bladder. J Urol Pathol. 1999;11:89–101
  13. Cam K, Yildirim A, Ozveri H, Turkeri L, Akdas A. The efficacy of neoadjuvant chemotherapy in invasive bladder cancer. Int Urol Nephrol. 2002;33:49–52
  14. Xiao GQ, Savage SJ, Gribetz ME, Burstein DE, Miller LK, Unger PD. The nested variant of urothelial carcinoma: clinicopathology of 2 cases. Arch Pathol Lab Med. 2003;127:e333–e336
  15. Lin O, Cardillo M, Dalbagni G, Linkov I, Hutchinson B, Reuter VE. Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 12 cases. Mod Pathol. 2003;16:1289–1298
  16. Mai KT, Elmontaser G, Perkins DG, Yazdi HM, Stinson WA, Thijssen A. Histopathological and immunohistochemical study of papillary urothelial neoplasms of low malignant potential and grade associated with extensive invasive low-grade urothelial carcinoma. BJU Int. 2004;94:544–547
  17. Billis A, Schenka AA, Ramos CC, Carneiro LT, Araujo V. Squamous and/or glandular differentiation in urothelial carcinoma: prevalence and significance in transurethral resections of the bladder. Int Urol Nephrol. 2001;33:631–633
  18. Ali-El-Dein B, Sarhan O, Hinev A, Ibrahiem el-HI, Nabeeh A, Ghoneim MA. Superficial bladder tumours: analysis of prognostic factors and construction of a predictive index. BJU Int. 2003;92:393–399
  19. Wasco MJ, Daignault S, Zhang Y, et al. Urothelial carcinoma with divergent histologic differentiation (mixed histologic features) predicts the presence of locally advanced bladder cancer when detected at transurethral resection. Urology. 2007;70:69–74
  20. Weizer AZ, Wasco MJ, Wang R, Daignault S, Lee CT, Shah RB. Presence of multiple adverse histologic features increases the odds of understaging in patients with T1 bladder cancer. J Urol. 2009;182:59–65
  21. Nigwekar P, Tamboli P, Amin MB, Osunkoya AO, Ben-Dor D, Amin MB. Plasmacytoid urothelial carcinoma: detailed analysis of morphology with clinicopathologic correlation in 17 cases. Am J Surg Pathol. 2009;33:417–424
  22. Kunju LP, Mehra R, Snyder M, Shah RB. Prostate-specific antigen, high-molecular weight cytokeratin (clone 34betaE12) and/or p63: an optimal immunohistochemical panel to distinguish poorly differentiated prostate adenocarcinoma from urothelial carcinoma. Am J Clin Pathol. 2006;125:675–681
  23. Black PC, Brown GA, Dinney CP. The impact of variant histology on the outcome of bladder cancer treated with curative intent. Urol Oncol. 2009;27:3–7
  24. Rosenberg JE. Current status of neoadjuvant and adjuvant chemotherapy for muscle-invasive bladder cancer. Expert Rev Anticancer Ther. 2007;7:1729–1736
  25. Rogers CG, Palapattu GS, Shariat SF, et al. Clinical outcomes following radical cystectomy for primary nontransitional cell carcinoma of the bladder compared to transitional cell carcinoma of the bladder. J Urol. 2006;175:2048–2053
  26. Kamat AM, Gee JR, Dinney CP, et al. The case for early cystectomy in the treatment of nonmuscle invasive micropapillary bladder carcinoma. J Urol. 2006;175:881–885
  27. Kamat AM, Dinney CP, Gee JR, et al. Micropapillary bladder cancer: a review of the University of Texas M.D. Anderson Cancer Center experience with 100 consecutive patients. Cancer. 2007;110:62–67
  28. Lagwinski N, Thomas A, Stephenson AJ, et al. Squamous cell carcinoma of the bladder: a clinicopathologic analysis of 45 cases. Am J Surg Pathol. 2007;31:1777–1787

PII: S0046-8177(09)00277-9

doi: 10.1016/j.humpath.2009.07.015

Human Pathology
Volume 41, Issue 2 , Pages 163-171 , February 2010

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