Human Pathology
Volume 41, Issue 2 , Pages 239-248 , February 2010

Refractory remodeling of the microenvironment by abnormal type V collagen, apoptosis, and immune response in non-small cell lung cancer

  • Paola Souza, MD

      Affiliations

    • Departament of Pathology, Faculdade de Medicina da Universidade de São Paulo 01246-903, Brazil
  • ,
  • Fabrizio Rizzardi

      Affiliations

    • Departament of Pathology, Faculdade de Medicina da Universidade de São Paulo 01246-903, Brazil
  • ,
  • Gustavo Noleto

      Affiliations

    • Departament of Pathology, Faculdade de Medicina da Universidade de São Paulo 01246-903, Brazil
  • ,
  • Marcelo Atanazio

      Affiliations

    • Departament of Pathology, Faculdade de Medicina da Universidade de São Paulo 01246-903, Brazil
  • ,
  • Osmar Bianchi

      Affiliations

    • Departament of Pathology, Faculdade de Medicina da Universidade de São Paulo 01246-903, Brazil
  • ,
  • Edwin Roger Parra, MD, PhD

      Affiliations

    • Departament of Pathology, Faculdade de Medicina da Universidade de São Paulo 01246-903, Brazil
  • ,
  • Walcy Rosolia Teodoro, PhD

      Affiliations

    • Discipline of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Brazil
  • ,
  • Solange Carrasco

      Affiliations

    • Discipline of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Brazil
  • ,
  • Ana Paula Pereira Velosa, PhD

      Affiliations

    • Discipline of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Brazil
  • ,
  • Sandra Fernezlian

      Affiliations

    • Departament of Pathology, Faculdade de Medicina da Universidade de São Paulo 01246-903, Brazil
  • ,
  • Alexandre Muxfeldt Ab'Saber, MD, PhD

      Affiliations

    • Departament of Pathology, Faculdade de Medicina da Universidade de São Paulo 01246-903, Brazil
  • ,
  • Leila Antonângelo, MD, PhD

      Affiliations

    • Departament of Pathology, Faculdade de Medicina da Universidade de São Paulo 01246-903, Brazil
  • ,
  • Tereza Takagaki, MD, PhD

      Affiliations

    • Oncology, Faculdade de Medicina da Universidade de São Paulo, Brazil
  • ,
  • Cláudia Goldenstein Schainberg, MD, PhD

      Affiliations

    • Discipline of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Brazil
  • ,
  • Natalino Hajime Yoshinari, MD, PhD

      Affiliations

    • Discipline of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Brazil
  • ,
  • Vera Luiza Capelozzi, MD, PhD

      Affiliations

    • Departament of Pathology, Faculdade de Medicina da Universidade de São Paulo 01246-903, Brazil
    • Corresponding Author InformationCorresponding author. Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP 01296-903, Brazil.

Received 30 May 2009 ,Revised 22 July 2009 ,Accepted 23 July 2009.

References 

  1. Aznavoorian S, Murphy AN, Stetler-Stevenson WG, Liotta LA. Molecular aspects of tumor cell invasion and metastasis. Cancer (Phila). 1993;71:1368–1383
  2. Pinto CA, Carvalho PEO, Antonangelo L, et al. Morphometric evaluation of tumor matrix metalloproteinase 9 predicts survival after surgical resection of adenocarcinoma of the lung. Clin Cancer Res. 2003;9:3098–3104
  3. Liotta LA, Rao CN, Barsky SH. Tumor invasion and the extracellular matrix. Lab Invest. 1983;49:636–649
  4. Demarchi LM, Reis MM, Palomino SAP, et al. Prognostic values of stroma proportion and PCNA, Ki-67 and p53 proteins in patients with resected adenocarcinoma of the lung. Mod Pathol. 2000;13:511–520
  5. Mayne R, Burgeson R. Structure and function of collagen types. In:  Ulecham R editors. Biology of Extracellular Matrix, 20th ed. London: Academic Press; 1993;p. 1–37
  6. Mares DC, Heidler KM, Smith GN, et al. Collagen V modulates alloantigen-induced pathology and immunology in the lung. Am J Respir Cell Mol Biol. 2000;23:62–70
  7. Linsenmayer TF, Fitch JM, Birk DE. Heterotypic collagen fibrils and stabilizing collagens. Controlling elements in corneal morphogenesis?. Ann N Y Acad Sci. 1990;580:143–160
  8. Luparello C, Sirchia R. Type V collagen regulates the expression of apoptotic and stress response genes by breast cancer cells. J Cell Physiol. 2005;202:411–421
  9. Minafra S, Morello V, Glorioso F, et al. A new line (8701-BC) from primary ductal infiltrating carcinoma of human breast. Br J Cancer. 1989;60:185–192
  10. Minafra S, Luparello C, Pucci-Minafra I, Sobel ME, Garbisa S. Adhesion of 8701-BC breast cancer cells to type V collagen and 67-kD receptor. J Cell Sci. 1992;102:323–328
  11. Schrump D, Altorki N, Henschke C, Carter D, Turrisi A, Gutierrez M. Non-small cell lung cancer. In:  De Vita V,  Hellman S,  Rosenberg S editor. Cancer: principles and practice of oncology. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2005;p. 753–754
  12. Bernardi FD, Capelozzi VL, Takagaki T, Younes R, Saldiva PH. Usefulness of morphometric evaluation of histopathological slides is useful in predicting long-term outcome of patients with squamous cell carcinoma of the lung. A preliminary report. Chest. 1995;107:614–620
  13. Bernardi FDC, Antonângelo L, Beyruti R, Takagaki T, Saldiva PHN, Capelozzi VL. Clinical, pathological and biological markers of prognosis in surgically resected squamous cell carcinoma of the lung. Mod Pathol. 1997;10:992–1000
  14. Carvalho HA, Takagaki TY, Saldiva PHN, Capelozzi V. Stereological estimates of the nuclear/cytoplasmic ratio and star volume on fibreoptic biopsies are of prognostic value for survival in a preliminary study of advanced squamous cell carcinoma of the lung. Histopathology. 1997;31:420–429
  15. Antonangelo L, Bernardi FDC, Capelozzi VL, et al. Morphometric evaluation of argyrophilic nucleolar organizer region (AgNOR) is useful in predicting long-term survival in squamous cell carcinoma of the lung. Chest. 1997;111:110–114
  16. Rodrigues OR, Antonângelo L, Franco Filho EC, Capelozzi VL, Saldiva PHN. Prognostic significance of argyrophilic nucleolar organizer region (AgNOR) staining in mediastinal lymph nodes metastasis and ressected non-small cell lung cancer. Jpn J Clin Oncol. 1997;27:298–304
  17. Minamoto H, Antonângelo L, Silva AGP, et al. Different cell and microenvironment profiles in metastatic and non-metastatic non-small cell lung carcinomas. Histopathology. 2003;43:427–443
  18. Matheus RS, Bernardi FD, Gallo CP, et al. Nuclear markers (star volume, mitotic index, AgNOR and Ki-67) of the primary tumor and its metastasis in non-small cell lung carcinomas. Pathol Res Pract. 2004;200:13–23
  19. Saito DM, Franco MR, Parra ER, et al. Cell cycle regulator in primary lung adenocarcinoma and its haematogenous metastases. Histopathology. 2007;50:525–527
  20. Parra ER, Park J, Rizzardi F, et al. Prognostic indice expression of cyclin-d1, c-erbB-2 and VEGF: metastases vs corresponding primary cancers and metastatic vs non-metastatic adenocarcinomas. Histol Histopathol. 2008;23:987–993
  21. In:  Travis W,  Brambilla E,  Hermelink-Muller HK,  Harris CC editor. Pathology and genetics of tumours of the lung, pleura, thymus and heart. Lyon: IARC Press; 2004;p. 26–50
  22. Weibel ER. Morphometry: stereological theory and practical methods. In:  Gil J editors. Models of lung disease—microscopy and structural methods. New York: Marcel Dekker; 1990;p. 199–247
  23. Miller EJ, Rhodes RK. Preparation and characterization of the different types of collagen. Methods Enzymol. 1982;82(Pt A):33–64
  24. Lane D, Harlow E. In: Antibodies: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1988;p. 56–81
  25. Parra ER, Kairalla RA, de Carvalho CR, Capelozzi VL. Abnormal deposition of collagen/elastic vascular fibres and prognostic significance in idiopathic interstitial pneumonias. Thorax. 2007;62:428–437
  26. Teodoro WR, Velosa AP, Witzel SS, et al. Architectural remodelling in lungs of rabbits induced by type V collagen immunization: a preliminary morphologic model to study diffuse connective tissue diseases. Pathol Res Pract. 2004;200:681–691
  27. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(Delta Delta C (T)) Method. Methods. 2001;25:402–408
  28. Bateman JF, Lamandè SR, Ramshaw JAM. Collagen superfamily. In:  Comper WD editors. Extracellular matrix volume 2, molecular components and interaction. Amsterdam: Harwood Acad. Public; 1996;p. 22–67
  29. Velosa AP, Teodoro WR, de Oliveira CC, et al. Collagen V nasal tolerance in experimental model of systemic sclerosis. Arch Dermatol Res. 2007;299:177–189
  30. Callado MR, Viana VS, Vendramini MB, et al. Autoantibody profile in the experimental model of scleroderma induced by type V human collagen. Immunology. 2007;122:38–46
  31. Takai KK, Hattori S, Irie S. Type V collagen distribution in liver is reconstructed in coculture system of hepatocytes and stellate cells; the possible functions of type V collagen in liver under normal and pathological conditions. Cell Struct Funct. 2001;26:289–302
  32. Chernousev MA, Stahl RC, Carey DJ. Schwann cell type V collagen inhibits axonal outgrowth and promotes Schwann cell migration via distinct adhesive activities of the collagen and noncollagen domains. J Neurosci. 2001;21:6125–6135
  33. Grotendorst GR, Seppã HE, Kleimanman HK, Martin GR. Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor. Proc Natl Acad Sci USA. 1981;78:3669–3672
  34. Ruggiero F, Champliaud MF, Garrone R, Aumailley M. Interactions between cells and collagen V molecules or single chains involve distinct mechanisms. Exp Cell Res. 1994;210:215–223
  35. Parekh TV, Wang XW, Makri-Werzen DM, Greenspan DS, Newman MJ. Type V collagen is an epithelial cell cycle inhibitor that is induced by and mimics the effects of transforming growth factor β1. Cell Growth Differ. 1998;9:423–433
  36. Konomi H, Toshihiko H, Kiyoo N, Masataka A. Localization of type V collagen and type IV collagen in human cornea, lung and skin. immunohistochemical evidence by anti-collagen antibodies characterized by immunoelectroblotting. Am J Pathol. 1984;116:417–426
  37. Reiser KM, Last JA. Type V collagen. Quantitation in normal lungs and in lungs of rats with bleomycin-induced pulmonary fibrosis. J Biol Chem. 1983;258:269–275
  38. Para ER, Teodoro WR, Velosa AP, de Oliveira CC, Yoshinari NH, Capelozzi VL. Interstitial and vascular type V collagen morphologic disorganization in usual interstitial pneumonia. J Histochem Cytochem. 2006;54:1315–1325
  39. Sgonc R. The vascular perspective of systemic sclerosis: of chickens, mice and men. Int Arch Allergy Immunol. 1999;120:169–176
  40. Bezerra MC, Teodoro WR, de Oliveira CC, et al. Scleroderma-like remodeling induced by type V collagen. Arch Dermatol Res. 2006;298:51–57
  41. Ogido LT, Teodoro WR, Velosa AP, et al. Abnormal collagen deposition in synovia after collagen type V immunization in rabbits. Histol Histopathol. 2008;23:263–269

 This study was supported by the following Brazilian agencies: the National Council for Scientific and Technological Development; the Foundation for the Support of Research of the State of São Paulo; and the Laboratories for Medical Research, Hospital das Clinicas, University of São Paulo Medical School.

 Silver Sponsorship by Oral Presentation at the 2009 Vienna European Respiratory Congress.

 Oral Presentation at the 2009 22nd European Congress of Pathology.

PII: S0046-8177(09)00280-9

doi: 10.1016/j.humpath.2009.07.018

Human Pathology
Volume 41, Issue 2 , Pages 239-248 , February 2010