« Previous
Next »
Human Pathology
Volume 41, Issue 2
, Pages 262-270
, February 2010
p53 expression in tumor-stromal fibroblasts is closely associated with the nodal metastasis and outcome of patients with invasive ductal carcinoma who received neoadjuvant therapy
References
- Stromal gene expression predicts clinical outcome in breast cancer. Nat Med. 2008;14:518–527
- Signal pathway profiling of epithelial and stromal compartments of colonic carcinoma reveals epithelial-mesenchymal transition. Oncogene. 2008;27:323–331
- Differential gene expression profile in breast cancer–derived stromal fibroblasts. Breast Cancer Res Treat. 2008;110:273–281
- Prognostic impact of syndecan-1 expression in invasive ductal carcinomas. Br J Cancer. 2008;98:1993–1998
- Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6–dependent manner. Cancer Res. 2008;68:9087–9095
- Proliferative activity of intratumoral fibroblasts is closely correlated with lymph node and distant organ metastases of invasive ductal carcinoma of the breast. Am J Pathol. 2000;156:1701–1710
- Highly proliferative fibroblasts forming fibrotic focus govern metastasis of invasive ductal carcinoma of the breast. Mod Pathol. 2001;14:325–337
- Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implication for tumorigenesis. Cancer Res. 2000;60:2562–2566
- Breast-cancer stromal cells with TP53 mutations and nodal metastases. N Engl J Med. 2007;357:2543–2551
- . Histological grading and prognosis in breast cancer. Br J Cancer. 1957;11:359–377
- Tumor necrosis is a prognostic predictor for early recurrence and death in lymph node–positive breast cancer: a 10-year follow-up study of 728 eastern cooperative oncology group patients. J Clin Oncol. 1993;11:1929–1935
- Fibrotic focus in infiltrating ductal carcinoma of the breast: a significant histopathological prognostic parameter for predicting the long-term survival of the patients. Breast Cancer Res Treat. 1998;49:195–208
- Prognostic significance of fibrotic focus in invasive ductal carcinoma of the breast: a prospective observational study. Mod Pathol. 2002;15:502–516
- . Biological and clinical considerations regarding the use of surgery and chemotherapy in the treatment of primary breast cancer. Cancer. 1977;40:574–587
- . Adjuvant chemotherapy in the primary management of breast cancer. Med Clin North Am. 1977;61:953–965
- Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J Natl Cancer Inst. 1993;85:200–206
- Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol. 1998;11:155–168
- Progesterone receptor by immunohistochemistry and clinical outcome in breast cancer: a validation study. Mod Pathol. 2004;17:1545–1554
- Estrogen- and progesterone-receptor status in ECOG2197: comparison of immunohistochemistry by local and central laboratories and quantitative reverse transcription polymerase chain reaction by central laboratory. J Clin Oncol. 2008;26:2473–2481
- American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. Arch Pathol Lab Med. 2007;131:18–43
- Breast cancer response to neoadjuvant chemotherapy: predictive markers and relation with outcome. Br J Cancer. 2003;88:406–412
- Influence of neoadjuvant therapy with epirubicin and docetaxel on the expression of HER2/neu in patients with breast cancer. Breast Cancer Res Treat. 2003;82:207–213
- . HER2/neu, p53, Ki67, and hormone receptors do not change during neoadjuvant chemotherapy in breast cancer. Virchows Arch. 2005;446:489–496
- Assessment of histologic features and expression of biomarkers in predicting pathologic response to anthracycline-based neoadjuvant chemotherapy in patients with breast cancer. Cancer. 2002;94:3107–3114
- Clinical response after two cycle compared to HER2, Ki-67, p53, and bcl-2 in independently predicting a pathologic complete response after preoperative chemotherapy in patients with operable carcinoma of the breast. Breast Cancer Res. 2008;10:R30
- . Should histologic type be taken into account when considering neoadjuvant chemotherapy in breast carcinoma?. Breast J. 2009;15:146–154
- . Akt promotes cisplatin resistance in human ovarian cancer cells through inhibition of p53 phosphorylation and nuclear function. Int J Cancer. 2008;122:534–546
- Attenuated p53 activation in tumor-associated stromal cells accompanies decreased sensitivity to etoposide and vincristine. Br J Cancer. 2008;99:118–125
- p53 mutations in stromal fibroblasts sensitize tumors against chemotherapy. Int J Cancer. 2008;123:967–971
- . Under pressure: stromal fibroblasts change their ways. Cell. 2005;123:985–987
- Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. Cell. 2006;123:1001–1011
- Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis. Cancer Res. 2005;65:1627–1630
- Molecular characterization of the tumor microenviroment in breast cancer. Cancer Cell. 2004;6:17–32
- Induction of epithelial to mesenchymal transition in PMC42-LA human breast carcinoma cells by carcinoma-associated fibroblast secreted factors. Breast Cancer Res. 2007;9:R19
- Breast-cancer stromal cells with TP53 mutations. N Engl J Med. 2008;10:1634–1635
- Multivariate prognostic evaluation of the mitotic activity index and fibrotic focus in node-negative invasive breast cancers. Eur J Cancer. 2005;41:2093–2101
- Intratumoral hypoxia resulting in the presence of a fibrotic focus is an independent predictor of early distant relapse in lymph node–negative breast cancer patients. Histopathology. 2001;39:416–425
☆ This study was supported in part by a Grant-in-Aid for Scientific Research (KAKENHI) (C) (19590378, 21590393) from Japan Society for the Promotion of Science and in part by a Grant-in-Aid for Cancer Research from the Ministry of Health, Labor and Welfare (20-16) of Japan.
PII: S0046-8177(09)00284-6
doi: 10.1016/j.humpath.2009.07.021
© 2010 Elsevier Inc. All rights reserved.
« Previous
Next »
Human Pathology
Volume 41, Issue 2
, Pages 262-270
, February 2010
