Human Pathology
Volume 41, Issue 1 , Pages 139-144 , January 2010

Clonal evidence for the progression of a testicular germ cell tumor to angiosarcoma

Received 17 April 2009 ,Revised 23 June 2009 ,Accepted 6 August 2009.

References 

  1. Ulbright TM. Germ cell neoplasia of the testis. Am J Surg Pathol. 1993;17:1075–1091
  2. Ulbright TM. Testis risk and prognostic factors. The pathologist's perspective. Urol Clin North Am. 1999;26:611–626
  3. Ahmed T, Bosl G, Hajdu S. Teratoma with malignant transformation in germ cell tumors in men. Cancer. 1985;56:860–863
  4. Michael H, Hull M, Foster RS, Sweeney CJ, Ulbright TM. Nephroblastoma-like tumors in patients with testicular germ cell neoplasms. Am J Surg Pathol. 1998;22:1107–1114
  5. Michael H, Hull M, Ulbright T, Foster R, Miller K. Primitive neuroectodermal tumors arising in testicular germ cell neoplasms. Am J Surg Pathol. 1997;21:896–904
  6. Motzer R, Amsterdam A, Prieto V, et al. Teratoma with malignant transformation: diverse malignant histologies arising in men with germ cell tumors. J Urol. 1998;159:133–138
  7. Ulbright TM, Loehrer PJ, Roth LM, Einhorn LH, Williams SD, Clark SA. The development of non-germ cell malignancies within germ cell tumors. Cancer. 1984;54:1824–1833
  8. Ulbright T, Clark S, Einhorn L. Angiosarcoma associated with germ cell tumors. Hum Pathol. 1985;16:268–272
  9. Hughes DF, Allen DC, O'Neill JJ. Angiosarcoma arising in a testicular teratoma. Histopathology. 1991;18:81–83
  10. Raz HR, Maurer R, von Hochstetter A, Hegglin J. Angiosarcoma following teratocarcinoma: “mutation”, successive malignancy or irradiation. Helv Chir Acta. 1989;56:355–357
  11. Lee KC, Yeung K, Welsh C, Katzen H, Haidak D. Angiosarcoma following treatment of testicular seminoma: case report and literature review. J Urol. 1995;153:1055–1056
  12. Steele GS, Clancy TE, Datta MW, Weinstein M, Richie JP. Angiosarcoma arising in a testicular teratoma. J Urol. 2000;163:1872–1873
  13. Sahoo S, Ryan CW, Recant WM, Yang XJ. Angiosarcoma masquerading as embryonal carcinoma in the metastasis from a mature testicular teratoma. Arch Pathol Lab Med. 2003;127:360–363
  14. Malagon HD, Valdez AM, Moran CA, Suster S. Germ cell tumors with sarcomatous components: a clinicopathologic and immunohistochemical study of 46 cases. Am J Surg Pathol. 2007;31:1356–1362
  15. Spiess PE, Pisters LL, Liu P, et al. Malignant transformation of testicular teratoma: a chemoresistant phenotype. Urol Oncol. 2008;26:595–599
  16. Meis-Kindblom JM, Kindblom LG. Angiosarcoma of soft tissue: a study of 80 cases. Am J Surg Pathol. 1998;22:683–697
  17. Mark RJ, Poen JC, Tran LM, Fu YS, Juillard GF. Angiosarcoma. A report of 67 patients and a review of the literature. Cancer. 1996;77:2400–2406
  18. Caldwell JB, Ryan MT, Benson PM, James WD. Cutaneous angiosarcoma arising in the radiation site of a congenital hemangioma. J Am Acad Dermatol. 1995;33:865–870
  19. Kernek KM, Ulbright TM, Zhang S, et al. Identical allelic losses in mature teratoma and other histologic components of malignant mixed germ cell tumors of the testis. Am J Pathol. 2003;163:2477–2484
  20. Jones TD, Wang M, Sung MT, et al. Clonal origin of metastatic testicular teratomas. Clin Cancer Res. 2006;12:5377–5383
  21. Cheng L, Zhang S, Wang M, et al. Molecular genetic evidence supporting the neoplastic nature of stromal cells in “fibrosis” after chemotherapy for testicular germ cell tumors. J Pathol. 2007;213:65–71
  22. Brandli DW, Ulbright TM, Foster RS, et al. Stroma adjacent to metastatic mature teratoma after chemotherapy for testicular germ cell tumors is derived from the same progenitor cells as the teratoma. Cancer Res. 2003;63:6063–6068
  23. Sung MT, Maclennan GT, Lopez-Beltran A, Zhang S, Montironi R, Cheng L. Primary mediastinal seminoma: a comprehensive assessment integrated with histology, immunohistochemistry, and fluorescence in situ hybridization for chromosome 12p abnormalities in 23 cases. Am J Surg Pathol. 2008;32:146–155
  24. Cossu-Rocca P, Zhang S, Roth LM, et al. Chromosome 12p abnormalities in dysgerminoma of the ovary: a FISH analysis. Mod Pathol. 2006;19:611–615
  25. Abbosh PH, Zhang S, Maclennan GT, et al. Germ cell origin of testicular carcinoid tumors. Clin Cancer Res. 2008;14:1393–1396
  26. Comiter CV, Kibel AS, Richie JP, Nucci MR, Renshaw AA. Prognostic features of teratomas with malignant transformation: a clinicopathological study of 21 cases. J Urol. 1998;159:859–863
  27. Allen EA, Burger PC, Epstein JI. Microcystic meningioma arising in a mixed germ cell tumor of the testis: a case report. Am J Surg Pathol. 1999;23:1131–1135
  28. Emerson RE, Ulbright TM, Zhang S, Foster RS, Eble JN, Cheng L. Nephroblastoma arising in a germ cell tumor of testicular origin. Am J Surg Pathol. 2004;28:687–692
  29. Donadio AC, Motzer RJ, Bajorin DF, et al. Chemotherapy for teratoma with malignant transformation. J Clin Oncol. 2003;21:4285–4291

PII: S0046-8177(09)00286-X

doi: 10.1016/j.humpath.2009.08.001

Human Pathology
Volume 41, Issue 1 , Pages 139-144 , January 2010