Human Pathology
Volume 41, Issue 2 , Pages 293-296 , February 2010

Invasive ductal breast cancer within a malignant phyllodes tumor: case report and assessment of clonality

  • Stephan Macher-Goeppinger, MD

      Affiliations

    • Institute of Pathology, Heidelberg University, 69120 Heidelberg, Germany
    • ,
  • Frederik Marme, MD

      Affiliations

    • Department of Gynaecology and Obstetrics, Heidelberg University, 69120 Heidelberg, Germany
    • ,
  • Benjamin Goeppert, MD

      Affiliations

    • Institute of Pathology, Heidelberg University, 69120 Heidelberg, Germany
    • ,
  • Roland Penzel, Phd

      Affiliations

    • Institute of Pathology, Heidelberg University, 69120 Heidelberg, Germany
    • ,
  • Peter Schirmacher, MD

      Affiliations

    • Institute of Pathology, Heidelberg University, 69120 Heidelberg, Germany
    • ,
  • Hans Peter Sinn, MD

      Affiliations

    • Institute of Pathology, Heidelberg University, 69120 Heidelberg, Germany
    • ,
  • Sebastian Aulmann, MD

      Affiliations

    • Institute of Pathology, Heidelberg University, 69120 Heidelberg, Germany
    • Corresponding Author InformationCorresponding author.

Received 17 April 2009 ,Revised 29 July 2009 ,Accepted 7 August 2009.

References 

  1. Mueller J. In: Ueber den feineren Bau und die Formen der krankhaften Geschwuelste. Berlin: G. Reimer; 1838;p. 56
  2. Lester J, Stout AP. Cystosarcoma phyllodes. Cancer. 1954;7:335–353
  3. Lee AHS. Recent developments in the histological diagnosis of spindle cell carcinoma, fibromatosis and phyllodes tumour of the breast. Histopathology. 2008;52:45–75
  4. Tan PH, Jayabaskar T, Chuah KL, et al. Phyllodes tumors of the breast. Am J Clin Pathol. 2005;123:529–540
  5. Haagensen CD. Cystosarcoma phyllodes. In: Diseases of the breast. 3rd ed. Philadelphia: WB Saunders; 1986;p. 284–312
  6. Oberman HA. Metaplastic carcinoma of the breast. Am J Surg Pathol. 1987;11:918–929
  7. Rosen PP. Unusual clinical presentations of carcinoma. In: Breast pathology. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2008;p. 721–758
  8. Harris M, Persaud V. Carcinosarcoma of the breast. J Pathol. 1974;112:99–105
  9. Wargotz ES, Norris HJ. Metaplastic carcinomas of the breast. III. Carcinosarcoma. Cancer. 1989;64:1490–1499
  10. Zhuang Z, Lininger RA, Man YG, Albuquerque A, Merino MJ, Tavassoli FA. Identical clonality of both components of mammary carcinosarcoma with differential loss of heterozygosity. Mod Pathol. 1997;10:354–362
  11. Abeln EC, Smit VT, Wessels JW, de Leeuw WJ, Cornelisse CJ, Fleuren GJ. Molecular genetic evidence for the conversion hypothesis of the origin of malignant mixed müllerian tumours. J Pathol. 1997;183:424–431
  12. Wada H, Enomoto T, Fujita M, et al. Molecular evidence that most but not all carcinosarcomas of the uterus are combination tumors. Cancer Res. 1997;57:5379–5385
  13. Nomura M, Inoue Y, Fujita S, et al. A case of noninvasive ductal carcinoma arising in malignant phyllodes tumor. Breast Cancer. 2006;13:89–94
  14. Korula A, Varghese J, Thomas M, Vyas F, Korula A. Malignant phyllodes tumour with intraductal and invasive carcinoma and lymph node metastasis. Singapore Med J. 2008;49:e318–e321
  15. Parfitt JR, Armstrong C, O'Malley F, Ross J, Tuck AB. In-situ and invasive carcinoma within a phyllodes tumor associated with lymph node metastases. World J Surg Oncol. 2004;2:46

PII: S0046-8177(09)00291-3

doi: 10.1016/j.humpath.2009.08.006

Human Pathology
Volume 41, Issue 2 , Pages 293-296 , February 2010

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