Human Pathology
Volume 41, Issue 3 , Pages 352-357 , March 2010

Epstein-Barr virus–positive diffuse large B-cell lymphoma in elderly patients is rare in Western populations

  • Sylvia Hoeller, MD

      Affiliations

    • Institute of Pathology, University Hospital, University of Basel, 4031 Basel, Switzerland
  • ,
  • Alexandar Tzankov, MD

      Affiliations

    • Institute of Pathology, University Hospital, University of Basel, 4031 Basel, Switzerland
  • ,
  • Stefano A. Pileri, MD

      Affiliations

    • Department of Hematology and Oncological Sciences “L. and A. Seràgnoli”, Hematopathology Section, Bologna University School of Medicine, St. Orsola Hospital, 40138 Bologna, Italy
  • ,
  • Philip Went, MD

      Affiliations

    • Institute of Pathology, Triemli Hospital, Birmensdorferstrasse 497, 8063 Zürich, Switzerland
  • ,
  • Stephan Dirnhofer, MD

      Affiliations

    • Institute of Pathology, University Hospital, University of Basel, 4031 Basel, Switzerland
    • Corresponding Author InformationCorresponding author.

Received 24 April 2009 ,Revised 17 June 2009 ,Accepted 2 July 2009.

References 

  1. Cohen JI, Bollard CM, Khanna R, Pittaluga S. Current understanding of the role of Epstein-Barr virus in lymphomagenesis and therapeutic approaches to EBV-associated lymphomas. Leuk Lymphoma. 2008;49(Suppl 1):27–34
  2. Dolcetti R. B lymphocytes and Epstein-Barr virus: the lesson of posttransplant lymphoproliferative disorders. Autoimmun Rev. 2007;7:96–101
  3. Kanegane H, Nomura K, Miyawaki T, Tosato G. Biological aspects of Epstein-Barr virus (EBV)-infected lymphocytes in chronic active EBV infection and associated malignancies. Crit Rev Oncol Hematol. 2002;44:239–249
  4. Nakamura S, Jaffe ES, Swerdlow SH. EBV positive diffuse large B-cell lymphoma of the elderly. In:  Swerdlow S,  Campo E,  Harris N, et al. editor. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. IARC: Lyon; 2008;p. 243–244
  5. Oyama T, Yamamoto K, Asano N, et al. Age-related EBV-associated B-cell lymphoproliferative disorders constitute a distinct clinicopathologic group: a study of 96 patients. Clin Cancer Res. 2007;13:5124–5132
  6. Oyama T, Ichimura K, Suzuki R, et al. Senile EBV+ B-cell lymphoproliferative disorders: a clinicopathologic study of 22 patients. Am J Surg Pathol. 2003;27:16–26
  7. Gibson SE, Hsi E. Epstein Barr Virus –positive B-cell lymphoma of the elderly at a United States tertary medical center: an uncommon aggressive lymphoma with a nongerminal center B-cell phenotype. Hum Pathol. 2009;
  8. Tzankov A, Went P, Zimpfer A, Dirnhofer S. Tissue microarray technology: principles, pitfalls and perspectives—lessons learned from hematological malignancies. Exp Gerontol. 2005;40:737–744
  9. Hans CP, Weisenburger DD, Greiner TC, et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 2004;103:275–282
  10. Kuze T, Nakamura N, Hashimoto Y, Sasaki Y, Abe M. The characteristics of Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma: comparison between EBV(+) and EBV(-) cases in Japanese population. Jpn J Cancer Res. 2000;91:1233–1240
  11. Shimoyama Y, Yamamoto K, Asano N, Oyama T, Kinoshita T, Nakamura S. Age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorders: special references to lymphomas surrounding this newly recognized clinicopathologic disease. Cancer Sci. 2008;99:1085–1091
  12. Kojima M, Sugiura I, Itoh H, et al. Histological varieties of Epstein-Barr virus-related lymph node lesion resembling autoimmune disease-like clinicopathological findings in middle-aged and elderly patients: a study of six cases. Pathol Res Pract. 2006;202:609–615
  13. Kojima M, Kashimura M, Itoh H, et al. Epstein-Barr virus-related reactive lymphoproliferative disorders in middle-aged or elderly patients presenting with atypical features. A clinicopathological study of six cases. Pathol Res Pract. 2007;203:587–591
  14. Kojima M, Morita Y, Nakamura N, Shimizu K, Murayama K, Nakamura S. Plasmacytic hyperplasia in age-related Epstein-Barr virus-associated lymphoproliferative disorders: a report of two cases. Pathol Res Pract. 2008;204:267–272
  15. Shiozawa E, Saito B, Yamochi-Onizuka T, et al. Senile EBV-associated B-cell lymphoproliferative disorder of indolent clinical phenotype with recurrence as aggressive lymphoma. Pathol Int. 2007;57:688–693
  16. Cho EY, Kim KH, Kim WS, Yoo KH, Koo HH, Ko YH. The spectrum of Epstein-Barr virus-associated lymphoproliferative disease in Korea: incidence of disease entities by age groups. J Korean Med Sci. 2008;23:185–192
  17. Perrine SP, Hermine O, Small T, et al. A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus-associated lymphoid malignancies. Blood. 2007;109:2571–2578
  18. Park S, Lee J, Ko YH, et al. The impact of Epstein-Barr virus status on clinical outcome in diffuse large B-cell lymphoma. Blood. 2007;110:972–978

PII: S0046-8177(09)00292-5

doi: 10.1016/j.humpath.2009.07.024

Human Pathology
Volume 41, Issue 3 , Pages 352-357 , March 2010