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Human Pathology
Volume 41, Issue 3
, Pages 358-365
, March 2010
Overexpression of cell division cycle 7 homolog is associated with gene amplification frequency in breast cancer
References
- . Cdc7p-Dbf4p becomes famous in the cell cycle. J Cell Sci. 2000;113(Pt 12):2111–2117
- . Functions of mammalian Cdc7 kinase in initiation/monitoring of DNA replication and development. Mutat Res. 2003;532:29–40
- . Cdc7 kinase complex: a key regulator in the initiation of DNA replication. J Cell Physiol. 2002;190:287–296
- Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin. J Biol Chem. 2006;281:39249–39261
- . Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. Mol Biol Cell. 2006;17:4459–4472
- Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells. J Cell Biochem. 2008;104:1075–1086
- Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells. Cancer Res. 2004;64:7110–7116
- . A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. J Biol Chem. 2005;280:13062–13070
- . ATR-dependent activation of p38 MAP kinase is responsible for apoptotic cell death in cells depleted of Cdc7. J Biol Chem. 2008;283:25171–25177
- . Cdc7 kinase mediates claspin phosphorylation in DNA replication checkpoint. Oncogene. 2008;27:3475–3482
- A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nat Chem Biol. 2008;4:357–365
- Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships. J Med Chem. 2008;51:487–501
- First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. J Med Chem. 2009;
- . Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation. Neoplasia. 2008;10:920–931
- Cdc7 expression in melanomas, Spitz tumors and melanocytic nevi. J Cutan Pathol. 2009;36:433–438
- Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma. Clin Cancer Res. 2009;
- . Tissue microarrays in drug discovery. Nat Rev Drug Discov. 2003;2:962–972
- Prognostic relevance of gene amplifications and coamplifications in breast cancer. Cancer Res. 2004;64:8534–8540
- Tissue microarrays for comparing molecular features with proliferation activity in breast cancer. Int J Cancer. 2006;118:2190–2194
- Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer. Nat Genet. 2007;39:655–660
- KIT (CD117)-positive breast cancers are infrequent and lack KIT gene mutations. Clin Cancer Res. 2004;10:178–183
- Immunohistochemical analysis of ER, PR, HER-2, CK 5/6, p63 and EGFR antigen expression in medullary breast cancer. Tumori. 2008;94:838–844
- . c-myc Amplification is associated with HER2 amplification and closely linked with cell proliferation in tissue microarray of nonselected breast cancers. Hum Pathol. 2005;36:634–639
- . Comparative genomic hybridization analysis of breast tumors with predetermined profiles of DNA amplification. Cancer Res. 1997;57:4368–4377
- . Intrinsic nuclear import activity of geminin is essential to prevent re-initiation of DNA replication in Xenopus eggs. Genes Cells. 2005;10:63–73
- . Amplification of chicken actin genes during myogenesis. In: Schimke RT editors. Gene amplification. Cold Spring Harbor (NY): Cold Spring Harbor Press; 1982;p. 137–146
- . Drosophila minichromosome maintenance 6 is required for chorion gene amplification and genomic replication. Mol Biol Cell. 2002;13:607–620
- . Building up the Drosophila eggshell: first of all the eggshell genes must be transcribed. Dev Dyn. 2008;237:2061–2072
- . The organization and amplification of two chromosomal domains containing Drosophila chorion genes. Cell. 1981;27:193–201
- . The Drosophila chiffon gene is required for chorion gene amplification, and is related to the yeast Dbf4 regulator of DNA replication and cell cycle. Development. 1999;126:4281–4293
- Molecular architecture of the human GINS complex. EMBO Rep. 2007;8:678–684
- . Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase. Genes Cells. 2007;12:745–758
- . An oncogene-induced DNA damage model for cancer development. Science. 2008;319:1352–1355
- . Cdc7 as a potential new target for cancer therapy. Drug News Perspect. 2008;21:481–488
- . DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene. 2007;26:7773–7779
PII: S0046-8177(09)00294-9
doi: 10.1016/j.humpath.2009.08.008
© 2010 Elsevier Inc. All rights reserved.
« Previous
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Human Pathology
Volume 41, Issue 3
, Pages 358-365
, March 2010
