Human Pathology
Volume 41, Issue 3 , Pages 326-335 , March 2010

Papillary squamous intraepithelial lesions of the uterine cervix: human papillomavirus-dependent changes in cell cycle expression and cytologic features

  • Cher-Wei Liang, MD

      Affiliations

    • Department of Pathology, Cathay General Hospital, Taipei 106, Taiwan
    • Department of Pathology, National Taiwan University Hospital, Taipei 100, Taiwan
    • ,
  • Ming-Chieh Lin, MD

      Affiliations

    • Department of Pathology, National Taiwan University Hospital, Taipei 100, Taiwan
    • ,
  • Chen-Hsiang Hsiao, MD

      Affiliations

    • Department of Pathology, National Taiwan University Hospital, Taipei 100, Taiwan
    • ,
  • Yi-Ting Lin, MS

      Affiliations

    • Department of Pathology, National Taiwan University Hospital, Taipei 100, Taiwan
    • ,
  • Kuan-Ting Kuo, MD

      Affiliations

    • Department of Pathology, National Taiwan University Hospital, Taipei 100, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Pathology, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei City 10001, Taiwan.

Received 10 February 2009 ,Revised 12 May 2009 ,Accepted 14 May 2009.

References 

  1. Ward BE, Saleh AM, Williams JV, Zitz JC, Crum CP. Papillary immature metaplasia of the cervix: a distinct subset of exophytic cervical condyloma associated with HPV-6/11 nucleic acids. Mod Pathol. 1992;5:391–395
  2. Trivijitsilp P, Mosher R, Sheets EE, Sun D, Crum CP. Papillary immature metaplasia (immature condyloma) of the cervix: a clinicopathologic analysis and comparison with papillary squamous carcinoma. Hum Pathol. 1998;29:641–648
  3. Duggan MA. Cytologic and histologic diagnosis and significance of controversial squamous lesions of the uterine cervix. Mod Pathol. 2000;13:252–260
  4. Crum CP, Rose PG. Cervical squamous neoplasia. In:  Crum CP,  Lee KR editor. Diagnostic gynecologic and obstetric pathology. Philadelphia, United States: Elsevier Saunders; 2006;p. 267–354
  5. Kang GH, Min K, Shim YH, Kim KR. Papillary immature metaplasia of the uterine cervix: a report of 5 cases with an emphasis on the differential diagnosis from reactive squamous metaplasia, high-grade squamous intraepithelial lesion and papillary squamous cell carcinoma. J Korean Med Sci. 2001;16:762–768
  6. Kuo KT, Chang HC, Hsiao CH, Lin MC. Increased Ki-67 proliferative index and absence of P16INK4 in CIN-HPV related pathogenic pathways different from cervical squamous intraepithelial lesion. Br J Ophthalmol. 2006;90:894–899
  7. Feoli-Fonseca JC, Oligny LL, Filion M, et al. A two-tier polymerase chain reaction direct sequencing method for detecting and typing human papillomaviruses in pathological specimens. Diagn Mol Pathol. 1998;7:317–323
  8. Jacobs MV, Snijders PJ, van den Brule AJ, Helmerhorst TJ, Meijer CJ, Walboomers JM. A general primer GP5+/GP6(+)-mediated PCR-enzyme immunoassay method for rapid detection of 14 high-risk and 6 low-risk human papillomavirus genotypes in cervical scrapings. J Clin Microbiol. 1997;35:791–795
  9. Huang HJ, Huang SL, Lin CY, et al. Human papillomavirus genotyping by a polymerase chain reaction-based genechip method in cervical carcinoma treated with neoadjuvant chemotherapy plus radical surgery. Int J Gynecol Cancer. 2004;14:639–649
  10. Kruse AJ, Skaland I, Janssen EA, et al. Quantitative molecular parameters to identify low-risk and high-risk early CIN lesions: role of markers of proliferative activity and differentiation and Rb availability. Int J Gynecol Pathol. 2004;23:100–109
  11. Baak JP, Kruse AJ, Garland SM, et al. Combined p53 and retinoblastoma protein detection identifies persistent and regressive cervical high-grade squamous intraepithelial lesions. Am J Surg Pathol. 2005;29:1062–1066
  12. Nucci MR, Castrillon DH, Bai H, et al. Biomarkers in diagnostic obstetric and gynecologic pathology: a review. Adv Anat Pathol. 2003;10:55–68
  13. Mosher RE, Lee KR, Trivijitsilp P, Crum CP. Cytologic correlates of papillary immature metaplasia (immature condyloma) of the cervix. Diagn Cytopathol. 1998;18:416–421
  14. Keating JT, Ince T, Crum CP. Surrogate biomarkers of HPV infection in cervical neoplasia screening and diagnosis. Adv Anat Pathol. 2001;8:83–92
  15. Klaes R, Benner A, Friedrich T, et al. p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol. 2002;26:1389–1399
  16. Branca M, Ciotti M, Santini D, et al. p16(INK4A) expression is related to grade of cin and high-risk human papillomavirus but does not predict virus clearance after conization or disease outcome. Int J Gynecol Pathol. 2004;23:354–365
  17. Negri G, Vittadello F, Romano F, et al. p16INK4a expression and progression risk of low-grade intraepithelial neoplasia of the cervix uteri. Virchows Arch. 2004;445:616–620
  18. Tringler B, Gup CJ, Singh M, et al. Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia. Hum Pathol. 2004;35:689–696
  19. Dray M, Russell P, Dalrymple C, et al. p16(INK4a) as a complementary marker of high-grade intraepithelial lesions of the uterine cervix. I: Experience with squamous lesions in 189 consecutive cervical biopsies. Pathology. 2005;37:112–124
  20. Guimaraes MC, Goncalves MA, Soares CP, Bettini JS, Duarte RA, Soares EG. Immunohistochemical expression of p16INK4a and bcl-2 according to HPV type and to the progression of cervical squamous intraepithelial lesions. J Histochem Cytochem. 2005;53:509–516
  21. Lorenzato M, Caudroy S, Bronner C, et al. Cell cycle and/or proliferation markers: what is the best method to discriminate cervical high-grade lesions?. Hum Pathol. 2005;36:1101–1107
  22. Wang JL, Zheng BY, Li XD, et al. p16INK4A and p14ARF expression pattern by immunohistochemistry in human papillomavirus-related cervical neoplasia. Mod Pathol. 2005;18:629–637
  23. Lambert AP, Anschau F, Schmitt VM. p16INK4A expression in cervical premalignant and malignant lesions. Exp Mol Pathol. 2006;80:192–196
  24. Eleuterio J, Giraldo PC, Goncalves AK, et al. Prognostic markers of high-grade squamous intraepithelial lesions: the role of p16INK4a and high-risk human papillomavirus. Acta Obstet Gynecol Scand. 2007;86:94–98
  25. Kalof AN, Evans MF, Simmons-Arnold L, Beatty BG, Cooper K. p16INK4A immunoexpression and HPV in situ hybridization signal patterns: potential markers of high-grade cervical intraepithelial neoplasia. Am J Surg Pathol. 2005;29:674–679
  26. Pinto AP, Carvalho MC, Kolb S, Tirone FA, Maia LR, Escobar CS. Value of cytology in papillary condylomatous lesions of the cervix. Acta Cytol. 2007;51:51–60

PII: S0046-8177(09)00304-9

doi: 10.1016/j.humpath.2009.05.015

Human Pathology
Volume 41, Issue 3 , Pages 326-335 , March 2010

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