Human Pathology
Volume 41, Issue 3 , Pages 443-446 , March 2010

Glioblastoma with signet-ring morphology: a case report and review of the literature

  • Sarah E. Martin, MD

      Affiliations

    • Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    • Corresponding Author InformationCorresponding author.
    • ,
  • Jose M. Bonnin, MD

      Affiliations

    • Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    • ,
  • David C. Hall, MD

      Affiliations

    • Indianapolis Neurosurgerical Group, Indianapolis, IN 46202, USA
    • ,
  • Eyas M. Hattab, MD

      Affiliations

    • Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA

Received 10 April 2009 ,Revised 25 June 2009 ,Accepted 21 August 2009.

References 

  1. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. WHO classification of tumours of the central nervous system. Lyon: International Agency for Research on Cancer; 2007;
  2. Miller CR, Perry A. Glioblastoma. Arch Pathol Lab Med. 2007;131:397–406
  3. Burger PC, Bernd W. Scheithauer. Atlas of tumor pathology: tumors of the central nervous system, third series, Fascicle 10. Washington, D.C.: Armed Forces Institute of Pathology; 1993;
  4. Vajtai I, Mucsi Z, Varga Z, Bodi I. Signet-ring cell ependymoma: case report with implications for pathogenesis and differential diagnosis. Pathol Res Pract. 1999;195:853–858
  5. Mikami Y, Shirabe T, Hata S, Watanabe A. Oligodendroglioma with signet-ring cell morphology: a case report with an immunohistochemical and ultrastructural study. Pathol Int. 1998;48:144–150
  6. Chan ACL, Ho LC, Yip WWL, Cheung FC. Pigmented ependymoma with lipofuscin and neuromelanin production. Arch Pathol Lab Med. 2003;127:872–875
  7. Deniz K, Tanriverdi F, Selcuklu A, Kontas O, Kelestimur F. Signet ring-like cells in pituitary adenoma. Pathol Res Pract. 2008;204:209–212
  8. Hirato J, Nakazato Y, Iijima M, et al. An unusual variant of ependymoma with extensive tumor cell vacuolization. Acta Neuropathol (Berl). 1997;93:310–316
  9. Kros JM, van den Brink WA, van Loon-van Luyt JJ, Stefanko SZ. Signet-ring cell oligodendroglioma–report of two cases and discussion of the differential diagnosis. Acta Neuropathol (Berl). 1997;93:638–643
  10. Mizuno J, Nakagawa H, Inoue T, Kondo S, Hara K, Hashizume Y. Signet-ring cell ependymoma with intratumoral hemorrhage in the medulla oblongata. J Clin Neurosci. 2005;12:711–714
  11. Ramos D, Cerda-Nicolas M, Lopez-Gines C, et al. Oligoastrocytoma with signet-ring cell differentiation. A morphological, ultrastructural and immunohistochemical study. Neurocirugia (Astur). 2003;14:46–51
  12. Sugita Y, Terasaki M, Shigemori M, Morimatsu M, Honda E, Oshima Y. Astroblastoma with unusual signet-ring-like cell components: a case report and literature review. Neuropathology. 2002;22:200–205
  13. Rosenblum MK, Erlandson RA, Budzilovich GN. The lipid-rich epithelioid glioblastoma. Am J Surg Pathol. 1991;15:925–934
  14. Kim H, Dorfman RF, Rappaport H. Signet ring cell lymphoma. A rare morphologic and functional expression of nodular (follicular) lymphoma. Am J Surg Pathol. 1978;2:119–132
  15. Pappas CT, Johnson PC, Sonntag VK. Signet-ring cell lymphoma of the central nervous system. Case report. J Neurosurg. 1998;69:789–792

☆ Presented in part, at the 85th annual meeting of the American Association of Neuropathologists, San Antonio, TX, June 11 to 14, 2009.

PII: S0046-8177(09)00319-0

doi: 10.1016/j.humpath.2009.08.017

Human Pathology
Volume 41, Issue 3 , Pages 443-446 , March 2010

Article Tools

* Image Usage & Resolution