Human Pathology
Volume 41, Issue 3 , Pages 385-391 , March 2010

Abnormal expression of telomerase/apoptosis limits type II alveolar epithelial cell replication in the early remodeling of usual interstitial pneumonia/idiopathic pulmonary fibrosis

  • Daniel Reis Waisberg, MD

      Affiliations

    • Departament of Pathology, Faculdade de Medicina da Universidade de São Paulo, Brasil
  • ,
  • João Valente Barbas-Filho, MD, PhD

      Affiliations

    • Division of Respiratory Diseases of Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, Brasil
  • ,
  • Edwin Roger Parra, MD, PhD

      Affiliations

    • Departament of Pathology, Faculdade de Medicina da Universidade de São Paulo, Brasil
  • ,
  • Sandra Fernezlian, BS

      Affiliations

    • Departament of Pathology, Faculdade de Medicina da Universidade de São Paulo, Brasil
  • ,
  • Carlos Roberto Ribeiro de Carvalho, MD, PhD

      Affiliations

    • Division of Respiratory Diseases of Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, Brasil
  • ,
  • Ronaldo Adib Kairalla, MD, PhD

      Affiliations

    • Division of Respiratory Diseases of Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, Brasil
  • ,
  • Vera Luiza Capelozzi, MD, PhD

      Affiliations

    • Departament of Pathology, Faculdade de Medicina da Universidade de São Paulo, Brasil
    • Corresponding Author InformationCorresponding author. Faculdade de Medicina da Universidade de São Paulo, Departamento de Patologia, CEP 01296-903, São Paulo, SP, Brasil.

Received 2 July 2009 ,Revised 21 August 2009 ,Accepted 26 August 2009.

References 

  1. Gross TJ, Hunninghake GW. Idiopathic pulmonary fibrosis. N Engl J Med. 2001;345:517–525
  2. Raghu G, Weycker D, Edelsberg J, Bradford WZ, Oster G. Incidence and prevalence of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2006;174:810–816
  3. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. Am J Respir Crit Care Med. 2002;165:277–304
  4. Katzenstein AL, Mukhopadhyay S, Myers JL. Diagnosis of usual interstitial pneumonia and distinction from other fibrosing interstitial lung diseases. Hum Pathol. 2008;39:1275–1294
  5. Selman M, Thannickal VJ, Pardo A, Zisman DA, Martinez FJ, Lynch JP. Idiopathic pulmonary fibrosis: Pathogenesis and therapeutic approaches. Drugs. 2004;64:405–430
  6. King TE, Schwarz MI, Brown K, et al. Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality. Am J Respir Crit Care Med. 2001;164:1025–1032
  7. Nicholson AG, Fulford LG, Colby TV, du Bois RM, Hansell DM, Wells AU. The relationship between individual histologic features and disease progression in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2002;166:173–177
  8. Baptista AL, Parra ER, Filho JV, Kairalla RA, de Carvalho CR, Capelozzi VL. Structural features of epithelial remodeling in usual interstitial pneumonia histologic pattern. Lung. 2006;184:239–244
  9. Kuwano K, Miyazaki H, Hagimoto N, et al. The involvement of Fas-Fas ligand pathway in fibrosing lung diseases. Am J Respir Cell Mol Biol. 1999;20:53–60
  10. Kuwano K, Hagimoto N, Kawasaki M, et al. Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. J Clin Invest. 1999;104:13–19
  11. Barbas-Filho JV, Ferreira MA, Sesso A, Kairalla RA, Carvalho CR, Capelozzi VL. Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IPF) ⁄ usual interstitial pneumonia (UIP). J Clin Pathol. 2001;54:132–138
  12. Tsakiri KD, Cronkhite JT, Kuan PJ, et al. Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci U S A. 2007;104:7552–7557
  13. d 'Adda di Fagagna F, Reaper PM, Clay-Farrace L, et al. A DNA damage check-point response in telomere-initiated senescence. Nature. 2003;426:194–198
  14. Hemann MT, Strong MA, Hao LY, Greider CW. The shortest telomere not average telomere length, is critical for cell viability and chromosome stability. Cell. 2001;107:67–77
  15. White ES, Lazar MH, Thannickal VJ. Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis. J Pathol. 2003;201:343–354
  16. Maher TM, Wells AU, Laurent GJ. Idiopathic pulmonary fibrosis: multiple causes and multiple mechanisms?. Eur Respir J. 2007;30:835–839
  17. Gavrieli Y, Sherman Y, Bem-Sasson AS. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992;119:4993–5501
  18. Wijsman JH, Jonker RR, Keijzer R, van de Velde CJ, Cornelise CJ, van Dierendonck JH. A new method to detect apoptosis in paraffin sections: in situ end labeling of fragmented DNA. J Histochem Cytochem. 1993;41:7–12
  19. Gundersen HJG, Bendtesen TF, Korbo L, et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS. 1988;96:379–394
  20. Evans MJ, Cabral LJ, Stevens RJ, Freeman G. Transformation of alveolar type 2 cells to type 1 cells following exposure to NO2. Exp Mol Pathol. 1975;22:142–150
  21. Rudolph KL, Chang S, Millard M, Schreiber-Agus N, Delpinho RA. Inhibition of experimental liver cirrohosis in mice by telomerase gene delivery. Science. 2000;287:1253–1258
  22. Driscoll B, Buckley S, Bui KC, Anderson KD, Warburton D. Telomerase in alveolar epithelial development and repair. Am J Physiol Lung Cell Mol Physiol. 2000;279:L1191–L1198
  23. Mondello C, Scovassi AI. Telomeros, telomerase, and apoptosis. Biochem Cell Biol. 2004;82:498–507
  24. Smith LL, Coller HÁ, Roberts JM. Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat Cell Biol. 2003;5:474–479
  25. Friendlenger ZG, Cohen PY, Golan O, Arish N, Dayan-Wallach S, Breuer R. Telomerase activity in alveolar epithelial development and repair. Eur Respir J. 2007;30:205–213
  26. Ramirez R, Carracedo J, Jimenez R, et al. Massive telomere loss is an early event of DNA damage-induced apoptosis. J Biol Chem. 2003;278:836–842
  27. Armanios M, Chin JL, Chang YP, et al. Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita. Proc Natl Acad Sci U S A. 2005;102:15960–15964
  28. Armanios MY, Chen JLLJ, Cogan JD, et al. W.Greider CW, Loyd JE. Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med. 2007;356:1317–1326
  29. Cronkhite JT, Xing C, Raghu G, et al. Telomere shortening in familial and sporadic pulmonary fibrosis. Am J Respir Crit Care Med. 2008;178:729–737
  30. Alder JK, Chen JJ, Lancaster L, et al. Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc Natl Acad Sci U S A. 2008;105:13051–13056

 This study was supported by the following Brazilian agencies: the National Council for Scientific and Technological Development, the Foundation for the Support of Research of the State of São Paulo, and the Laboratories for Medical Research, Hospital das Clinicas, Faculdade de Medicina da Universidade de São Paulo.

PII: S0046-8177(09)00320-7

doi: 10.1016/j.humpath.2009.08.019

Human Pathology
Volume 41, Issue 3 , Pages 385-391 , March 2010