Human Pathology
Volume 41, Issue 3 , Pages 425-430 , March 2010

End-stage nonalcoholic fatty liver disease: evaluation of pathomorphologic features and relationship to cryptogenic cirrhosis from study of explant livers in a living donor liver transplant program

  • Nabeen C. Nayak, MD

      Affiliations

    • Department of Pathology, Sir Ganga Ram Hospital, New Delhi 110060, India
    • Corresponding Author InformationCorresponding author.
    • ,
  • Nandini Vasdev, MD

      Affiliations

    • Department of Pathology, Sir Ganga Ram Hospital, New Delhi 110060, India
    • ,
  • Sanjiv Saigal, MD

      Affiliations

    • Department of Liver Transplant, Sir Ganga Ram Hospital, New Delhi 110060, India
    • ,
  • Arvinder S. Soin, MS

      Affiliations

    • Department of Liver Transplant, Sir Ganga Ram Hospital, New Delhi 110060, India

Received 26 December 2008 ,Revised 2 May 2009 ,Accepted 3 June 2009.

References 

  1. Anthony PP, Ishak KG, Nayak NC, Poulsen HE, Scheuer PJ, Sobin LH. The morphology of cirrhosis. Recommendations on definition, nomenclature and classification by a working group sponsored by the World Health Organization. J Clin Pathol. 1978;31:395–414
  2. Maheshwari A, Thuluvath PJ. Cryptogenic cirrhosis and NAFLD: are they related?. Am J Gastroenterol. 2006;101:664–668
  3. Sakugawa H, Nakasone H, Nakayoshi T, et al. Clinical characteristics of patients with cryptogenic liver cirrhosis in Okinawa. Japan. Hepatogastroenterology. 2003;50:2005–2008
  4. Kodali VP, Gordon SC, Silverman AL, McCray DG. Cryptogenic liver disease in the United States: further evidence for non-A, non-B, and non-C hepatitis. Am J Gastroenterol. 1994;89:1836–1839
  5. Nayak NC, Vasdev HG, Gulwani H, Saigal S, Soin AS. Etiologic basis of end stage chronic liver disease in adults: A study on native liver explants. Submitted for publication.
  6. Saberifiroozi M, Serati AR, Malekhosseini SA, et al. Analysis of patients listed for liver transplantation in Shiraz. Iran. Indian J Gastroenterol. 2006;25:11–13
  7. Ayata G, Gordon FD, Lewis WD, et al. Cryptogenic cirrhosis: clinicopathologic findings at and after liver transplantation. Hum Pathol. 2002;33:1098–1104
  8. Mendez-Sanchez N, Aguilar-Ramirez JR, Reyes A, et al. Etiology of liver cirrhosis in Mexico. Ann Hepatol. 2004;3:30–33
  9. Czaja AJ, Carpenter HA, Santrach PJ, Moore SB, Homburger HA. The nature and prognosis of severe cryptogenic chronic active hepatitis. Gastroenterology. 1993;104:1755–1761
  10. Brunt EM. Pathology of nonalcoholic steatohepatitis. Hepatol Res. 2005;3368–3371
  11. Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 2006;43(Suppl 1):S99–S112
  12. Sanjeevi A, Lyden E, Sunderman B, Weseman R, Ashwathnarayan R, Mukherjee S. Outcomes of liver transplantation for cryptogenic cirrhosis: a single-center study of 71 patients. Transplant Proc. 2003;35:2977–2980
  13. Adams LA, Sanderson S, Lindor KD, Angulo P. The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. J Hepatol. 2005;42:132–138
  14. Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology. 1990;11:74–80
  15. Harrison SA, Torgerson S, Hayashi PH. The natural history of nonalcoholic fatty liver disease: a clinical histopathological study. Am J Gastroenterol. 2003;98:2042–2047
  16. Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology. 2003;37:1202–1219
  17. Agarwal SR, Malhotra V, Sakhuja P, Sarin SK. Clinical, biochemical and histological profile of nonalcoholic steatohepatitis. Indian J Gastroenterol. 2001;20:183–186
  18. Bacon BR, Farahvash MJ, Janney CG, Neuschwander-Tetri BA. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology. 1994;107:1103–1109
  19. Sanyal AJ. AGA technical review on nonalcoholic fatty liver disease. Gastroenterology. 2002;123:1705–1725
  20. Brunt EM. Nonalcoholic steatohepatitis: pathologic features and differential diagnosis. Semin Diagn Pathol. 2005;22:330–338
  21. Vasdev N, Kakati AG, Saigal S, Nayak NC. Spectrum of histological features in nonalcoholic fatty liver disease. Natl Med J India. 2007;20:282–287
  22. Brunt EM. Alcoholic and nonalcoholic steatohepatitis. Clin Liver Dis 2002; 6:399-420, vii.
  23. Ratziu V, Charlotte F, Heurtier A, et al. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology. 2005;128:1898–1906
  24. In:  Burt AD,  Portmann BC,  Ferrell LD editor. MacSween's pathology of the liver. 5th ed. London: Churchill Livingstone; 2006;
  25. Caldwell SH, Oelsner DH, Iezzoni JC, Hespenheide EE, Battle EH, Driscoll CJ. Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease. Hepatology. 1999;29:664–669
  26. Goldar-Najafi A, Gordon FD, Lewis WD, et al. Liver transplantation for alcoholic liver disease with or without hepatitis C. Int J Surg Pathol. 2002;10:115–122
  27. Kojima H, Sakurai S, Matsumura M, et al. Cryptogenic cirrhosis in the region where obesity is not prevalent. World J Gastroenterol. 2006;12:2080–2085

PII: S0046-8177(09)00328-1

doi: 10.1016/j.humpath.2009.06.021

Human Pathology
Volume 41, Issue 3 , Pages 425-430 , March 2010

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