Human Pathology
Volume 41, Issue 3 , Pages 447-451, March 2010

Case report: focal nesidioblastosis (“nesidioblastoma”) in an adult

  • Michele K. McElroy, MD

      Affiliations

    • University of California San Diego Department of Pathology, San Diego, CA, USA
    • ,
  • Andrew M. Lowy, MD

      Affiliations

    • University of California San Diego Department of Surgery, Division of Surgical Oncology, San Diego, CA, USA
    • ,
  • Noel Weidner, MD

      Affiliations

    • University of California San Diego Department of Pathology, San Diego, CA, USA
    • Corresponding Author InformationCorresponding author. UCSD Department of Pathology, 200 W. Arbor Dr #8720, San Diego, CA 92103-8720, USA.

Received 21 July 2009; received in revised form 2 September 2009; accepted 9 September 2009. published online 11 December 2009.

Summary 

Adult nesidioblastosis is an uncommon cause of hyperinsulinemic hypoglycemia characterized by diffuse islet hyperplasia with β-cell hypertrophy and atypia. The cause of nesidioblastosis in adults is unclear but may be different from nesidioblastosis in infants. In contrast to infants, a focal form of adult nesidioblastosis (ie, “nesidioblastoma”) has not been documented, although proposed. We report a 44-year-old man with symptomatic hypoglycemia and localized nesidioblastosis treated with surgical enucleation resulting in normalization of blood glucose. Postoperative euglycemia has persisted in this patient to date (4 months at the time of manuscript submission).

Keywords: Adult nesidioblastosis, Persistent hyperinsulinemic hypoglycemia

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PII: S0046-8177(09)00330-X

doi:10.1016/j.humpath.2009.09.002

Human Pathology
Volume 41, Issue 3 , Pages 447-451, March 2010

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