Human Pathology
Volume 41, Issue 3 , Pages 447-451 , March 2010

Case report: focal nesidioblastosis (“nesidioblastoma”) in an adult

  • Michele K. McElroy, MD

      Affiliations

    • University of California San Diego Department of Pathology, San Diego, CA, USA
    • ,
  • Andrew M. Lowy, MD

      Affiliations

    • University of California San Diego Department of Surgery, Division of Surgical Oncology, San Diego, CA, USA
    • ,
  • Noel Weidner, MD

      Affiliations

    • University of California San Diego Department of Pathology, San Diego, CA, USA
    • Corresponding Author InformationCorresponding author. UCSD Department of Pathology, 200 W. Arbor Dr #8720, San Diego, CA 92103-8720, USA.

Received 21 July 2009 ,Revised 2 September 2009 ,Accepted 9 September 2009.

References 

  1. Witteles RM, Straus IF, Sugg SL, Koka MR, Costa EA, Kaplan EL. Adult-onset nesidioblastosis causing hypoglycemia: an important clinical entity and continuing treatment dilemma. Arch Surg. 2001;136:656–663
  2. Thompson GB, Service FJ, Andrews JC, et al. Noninsulinoma pancreatogenous hypoglycemia syndrome: an update in 10 surgically treated patients. Surgery. 2000;128:937–944[discussion 944-935]
  3. Kloppel G, Anlauf M, Raffel A, Perren A, Knoefel WT. Adult diffuse nesidioblastosis: genetically or environmentally induced?. Hum Pathol. 2008;39:3–8
  4. Sandler R, Horwitz DL, Rubenstein AH, Kuzuya H. Hypoglycemia and endogenous hyperinsulinism complicating diabetes mellitus. Application of the C-peptide assay to diagnosis and therapy. Am J Med. 1975;59:730–736
  5. Starke A, Saddig C, Kirch B, Tschahargane C, Goretzki P. Islet hyperplasia in adults: challenge to preoperatively diagnose non-insulinoma pancreatogenic hypoglycemia syndrome. World J Surg. 2006;30:670–679
  6. Kenney B, Tormey CA, Qin L, Sosa JA, Jain D, Neto A. Adult nesidioblastosis. Clinicopathologic correlation between pre-operative selective arterial calcium stimulation studies and post-operative pathologic findings. JOP. 2008;9:504–511
  7. Rumilla KM, Erickson LA, Service FJ, et al. Hyperinsulinemic hypoglycemia with nesidioblastosis: histologic features and growth factor expression. Mod Pathol. 2009;22:239–245
  8. Cummings DE. Gastric bypass and nesidioblastosis—too much of a good thing for islets?. N Engl J Med. 2005;353:300–302
  9. Dissanayake AS, Jones V, Fernando DJ. Adult hyperinsulinaemic hypoglycaemia caused by coexisting nesidioblastosis and insulinoma. Eur J Intern Med. 2008;19:303
  10. Anlauf M, Schlenger R, Perren A, et al. Microadenomatosis of the endocrine pancreas in patients with and without the multiple endocrine neoplasia type 1 syndrome. Am J Surg Pathol. 2006;30:560–574
  11. Anlauf M, Wieben D, Perren A, et al. Persistent hyperinsulinemic hypoglycemia in 15 adults with diffuse nesidioblastosis: diagnostic criteria, incidence, and characterization of beta-cell changes. Am J Surg Pathol. 2005;29:524–533
  12. Sempoux C, Guiot Y, Dubois D, et al. Pancreatic B-cell proliferation in persistent hyperinsulinemic hypoglycemia of infancy: an immunohistochemical study of 18 cases. Mod Pathol. 1998;11:444–449
  13. Casanova D, Polavieja MG, Naranjo A, et al. Surgical treatment of persistent hyperinsulinemic hypoglycemia (PHH) (insulinoma and nesidioblastosis). Langenbecks Arch Surg. 2007;392:663–670
  14. Clancy TE, Moore FD, Zinner MJ. Post-gastric bypass hyperinsulinism with nesidioblastosis: subtotal or total pancreatectomy may be needed to prevent recurrent hypoglycemia. J Gastrointest Surg. 2006;10:1116–1119

PII: S0046-8177(09)00330-X

doi: 10.1016/j.humpath.2009.09.002

Human Pathology
Volume 41, Issue 3 , Pages 447-451 , March 2010

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