Human Pathology
Volume 41, Issue 4 , Pages 513-521 , April 2010

Mucinous nonneoplastic cyst of the pancreas: apomucin phenotype distinguishes this entity from intraductal papillary mucinous neoplasm

  • Wenqing Cao, MD

      Affiliations

    • Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    • These two authors contributed equally to this study.
    • ,
  • Brain P. Adley, MD

      Affiliations

    • Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    • These two authors contributed equally to this study.
    • ,
  • Jie Liao, MD

      Affiliations

    • Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    • ,
  • Xiaoqi Lin, MD, PhD

      Affiliations

    • Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    • ,
  • Mark Talamonti, MD

      Affiliations

    • Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    • ,
  • David J. Bentrem, MD

      Affiliations

    • Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    • ,
  • Sambasiva M. Rao, MD

      Affiliations

    • Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    • Corresponding Author InformationCorresponding authors.
    • ,
  • Guang-Yu Yang, MD, PhD

      Affiliations

    • Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    • Corresponding Author InformationCorresponding authors.

Received 19 January 2009 ,Revised 15 May 2009 ,Accepted 21 May 2009.

References 

  1. Khalid A, Brugge W. ACG practice guidelines for the diagnosis and management of neoplastic pancreatic cysts. Am J Gastroenterol. 2007;102:2339–2349
  2. Adsay NV. Cystic neoplasia of the pancreas: pathology and biology. J Gastrointest Surg. 2008;12:401–404
  3. Kosmahl M, Pauser U, Peters K, et al. Cystic neoplasms of the pancreas and tumor-like lesions with cystic features: a review of 418 cases and a classification proposal. Virchows Arch. 2004;445:168–178
  4. Brunner A, Ladurner R, Kosmahl M, Mikuz G, Tzankov A. Mucinous nonneoplastic cyst of the pancreas accompanied by non-parasitic asymptomatic liver cysts. Virchows Arch. 2004;444:482–484
  5. Kosmahl M, Egawa N, Schroder S, Carneiro F, Luttges J, Kloppel G. Mucinous nonneoplastic cyst of the pancreas: a novel nonneoplastic cystic change?. Mod Pathol. 2002;15:154–158
  6. Goh BK, Tan YM, Tan PH, Ooi LL. Mucinous nonneoplastic cyst of the pancreas: a truly novel pathological entity?. World J Gastroenterol. 2005;11:2045–2047
  7. Goh BK, Tan YM, Chung YF, et al. Non-neoplastic cystic and cystic-like lesions of the pancreas: may mimic pancreatic cystic neoplasms. ANZ J Surg. 2006;76:325–331
  8. Hruban RH, Klimstra DS. Tumors of the pancreas. In:  Hahn KS editors. Washington, DC: American Registry of Pathology; 2007;p. 358–360
  9. Uchida T, Ohashi H, Aoki E, et al. Clonality analysis by methylation-specific PCR for the human androgenreceptor gene (HUMARA-MSP). Leukemia. 2000;14:207–212
  10. Kubota T, Nonoyama S, Tonoki H, et al. A new assay for the analysis of X-chromosome inactivation based on methylation-specific PCR. Hum Genet. 1999;104:49–55
  11. Takaori K. Current understanding of precursors to pancreatic cancer. J Hepatobiliary Pancreat Surg. 2007;14:217–223
  12. Brugge WR, Lauwers GY, Sahani D, Fernandez-del Castillo C, Warshaw AL. Cystic neoplasms of the pancreas. N Engl J Med. 2004;351:1218–1226
  13. Zhai J, Sarkar R, Ylagan L. Pancreatic mucinous lesions: a retrospective analysis with cytohistological correlation. Diagn Cytopathol. 2006;34:724–730
  14. Bassi C, Sarr MG, Lillemoe KD, Reber HA. Natural history of intraductal papillary mucinous neoplasms (IPMN): current evidence and implications for management. J Gastrointest Surg. 2008;12:645–650
  15. Lévy P, Jouannaud V, O'Toole D, et al. Natural history of intraductal papillary mucinous tumors of the pancreas: actuarial risk of malignancy. Clin Gastroenterol Hepatol. 2006;4:460–468
  16. Yasuda H, Takada T, Amano H, Yoshida M. Surgery for mucin-producing pancreatic tumor. Hepatogastroenterology. 1998;45:2009–2015

☆ This study was partially supported by NIH R21 CA122514 grant.

PII: S0046-8177(09)00333-5

doi: 10.1016/j.humpath.2009.05.017

Human Pathology
Volume 41, Issue 4 , Pages 513-521 , April 2010

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