Human Pathology
Volume 41, Issue 4 , Pages 540-551 , April 2010

Defining the borders of splenic marginal zone lymphoma: a multiparameter study

  • Scott D. Dufresne, MD

      Affiliations

    • Division of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
  • ,
  • Raymond E. Felgar, MD, PhD

      Affiliations

    • Division of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
  • ,
  • Rachel L. Sargent, MD

      Affiliations

    • Division of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
  • ,
  • Urvashi Surti, PhD

      Affiliations

    • Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    • Pittsburgh Cytogenetics Laboratory, Magee-Womens Hospital of UPMC, Pittsburgh, PA 15213, USA
  • ,
  • Susanne M. Gollin, PhD

      Affiliations

    • Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    • Pittsburgh Cytogenetics Laboratory, Magee-Womens Hospital of UPMC, Pittsburgh, PA 15213, USA
    • Department of Human Genetics, University of Pittsburgh Graduate School of Public Health and University of Pittsburgh Cancer Institute Cytogenetics Facility, Pittsburgh, PA 15213, USA
  • ,
  • Ellen D. McPhail, MD

      Affiliations

    • Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 53902, USA
  • ,
  • James R. Cook, MD, PhD

      Affiliations

    • Department of Clinical Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
  • ,
  • Steven H. Swerdlow, MD

      Affiliations

    • Division of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    • Corresponding Author InformationCorresponding author. Division of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, UPMC-Presbyterian Hospital, Pittsburgh, PA 15213, USA.

Received 26 June 2009 ,Revised 12 September 2009 ,Accepted 18 September 2009.

References 

  1. Isaacson PG, Piris M, Catovsky D, et al. Splenic marginal zone lymphoma. In:  Jaffe ES,  Harris NL,  Stein H,  Vardiman JW editor. Pathology and genetics of tumors of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2001;p. 135–137
  2. Hammer RD, Glick AD, Greer JP, Collins RD, Cousar JB. Splenic marginal zone lymphoma. A distinct B-cell neoplasm. Am J Surg Pathol. 1996;20:613–626
  3. Isaacson PG, Piris M, Berger F, et al. Splenic marginal zone lymphoma. In:  Swerdlow SH,  Campo E,  Harris NL,  Jaffe ES,  Pileri SA,  Stein H,  Jurgen T,  Vardiman JW editor. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2008;p. 185–187
  4. Boonstra R, Bosga-Bouwer A, van Imhoff GW, et al. Splenic marginal zone lymphomas presenting with splenomegaly and typical immunophenotype are characterized by allelic loss in 7q31-32. Mod Pathol. 2003;16:1210–1217
  5. Matutes E, Oscier D, Montalban C, et al. Splenic marginal zone lymphoma proposals for a revision of diagnostic, staging and therapeutic criteria. Leukemia. 2008;22:487–495
  6. Papadaki T, Stamatopoulos K, Belessi C, et al. Splenic marginal-zone lymphoma: one or more entities? A histologic, immunohistochemical, and molecular study of 42 cases. Am J Surg Pathol. 2007;31:438–446
  7. Callet-Bauchu E, Baseggio L, Felman P, et al. Cytogenetic analysis delineates a spectrum of chromosomal changes that can distinguish non-MALT marginal zone B-cell lymphomas among mature B-cell entities: a description of 103 cases. Leukemia. 2005;19:1818–1823
  8. Corcoran MM, Mould SJ, Orchard JA, et al. Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations. Oncogene. 1999;18:6271–6277
  9. Mateo M, Mollejo M, Villuendas R, et al. 7q31-32 allelic loss is a frequent finding in splenic marginal zone lymphoma. Am J Pathol. 1999;154:1583–1589
  10. Sole F, Woessner S, Florensa L, et al. Frequent involvement of chromosomes 1, 3, 7 and 8 in splenic marginal zone B-cell lymphoma. Br J Haematol. 1997;98:446–449
  11. Remstein ED, Law M, Mollejo M, Piris MA, Kurtin PJ, Dogan A. The prevalence of IG translocations and 7q32 deletions in splenic marginal zone lymphoma. Leukemia. 2008;22:1268–1272
  12. Wotherspoon AC, Finn TM, Isaacson PG. Trisomy 3 in low-grade B-cell lymphomas of mucosa-associated lymphoid tissue. Blood. 1995;85:2000–2004
  13. Piris M, Foucar K, Mollejo M, Campo E, Falini B. Splenic B-cell lymphoma/leukaemia, unclassifiable. In:  Swerdlow SH,  Campo E,  Harris NL,  Jaffe ES,  Pileri SA,  Stein H,  Thiele J,  Vardiman JW editor. WHO classification of tumors of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2008;p. 191–193
  14. Mollejo M, Algara P, Mateo MS, et al. Splenic small B-cell lymphoma with predominant red pulp involvement: a diffuse variant of splenic marginal zone lymphoma?. Histopathology. 2002;40:22–30
  15. Soma LA, Gollin SM, Remstein ED, et al. Splenic small B-cell lymphoma with IGH/BCL3 translocation. Hum Pathol. 2006;37:218–230
  16. Chen D, Law ME, Theis JD, et al. Clinicopathologic features of CDK6 translocation-associated B-cell lymphoproliferative disorders. Am J Surg Pathol. 2009;33:720–729
  17. Sherer ME, Shekhter-Levin S, Krause JR, Joyce RA, Gollin SM. Atypical (7;19) translocation in acute myelomonocytic leukemia. Cancer Genet Cytogenet. 1991;57:169–173
  18. Isaacson PG, Matutes E, Burke M, Catovsky D. The histopathology of splenic lymphoma with villous lymphocytes. Blood. 1994;84:3828–3834
  19. Mollejo M, Menarguez J, Lloret E, et al. Splenic marginal zone lymphoma: a distinctive type of low-grade B-cell lymphoma. A clinicopathological study of 13 cases. Am J Surg Pathol. 1995;19:1146–1157
  20. Traverse-Glehen A, Baseggio L, Bauchu EC, et al. Splenic red pulp lymphoma with numerous basophilic villous lymphocytes: a distinct clinicopathologic and molecular entity?. Blood. 2008;111:2253–2260
  21. Piris MA, Mollejo M, Campo E, Menarguez J, Flores T, Isaacson PG. A marginal zone pattern may be found in different varieties of non-Hodgkin's lymphoma: the morphology and immunohistology of splenic involvement by B-cell lymphomas simulating splenic marginal zone lymphoma. Histopathology. 1998;33:230–239
  22. Huh YO, Abruzzo LV, Rassidakis GZ, et al. The t(14;19)(q32;q13)-positive small B-cell leukaemia: a clinicopathologic and cytogenetic study of seven cases. Br J Haematol. 2007;136:220–228
  23. Isaacson PG. Splenic marginal zone lymphoma. Blood. 1996;88:751–752
  24. Steiniger B, Timphus EM, Barth PJ. The splenic marginal zone in humans and rodents: an enigmatic compartment and its inhabitants. Histochem Cell Biol. 2006;126:641–648
  25. Audouin J, Le Tourneau A, Molina T, et al. Patterns of bone marrow involvement in 58 patients presenting primary splenic marginal zone lymphoma with or without circulating villous lymphocytes. Br J Haematol. 2003;122:404–412
  26. Matutes E, Morilla R, Owusu-Ankomah K, Houlihan A, Catovsky D. The immunophenotype of splenic lymphoma with villous lymphocytes and its relevance to the differential diagnosis with other B-cell disorders. Blood. 1994;83:1558–1562
  27. Swerdlow SH, Murray LJ, Habeshaw JA, Stansfeld AG. Lymphocytic lymphoma/B-chronic lymphocytic leukaemia—an immunohistopathological study of peripheral B lymphocyte neoplasia. Br J Cancer. 1984;50:587–599
  28. Van Huyen JP, Molina T, Delmer A, et al. Splenic marginal zone lymphoma with or without plasmacytic differentiation. Am J Surg Pathol. 2000;24:1581–1592
  29. Swerdlow SH, Berger F, Pileri SA, Harris NL, Jaffe ES, Stein H. Lymphoplasmacytic lymphoma. In:  Swerdlow SH,  Campo E,  Harris NL,  Jaffe ES,  Pileri SA,  Stein H,  Thiele J,  Vardiman JW editor. WHO classification of tumours of haematopoietic and lymphoid tissues. IARC: Lyon; 2008;p. 194–195
  30. Sole F, Salido M, Espinet B, et al. Splenic marginal zone B-cell lymphomas: two cytogenetic subtypes, one with gain of 3q and the other with loss of 7q. Haematologica. 2001;86:71–77
  31. Dierlamm J, Rosenberg C, Stul M, et al. Characteristic pattern of chromosomal gains and losses in marginal zone B cell lymphoma detected by comparative genomic hybridization. Leukemia. 1997;11:747–758
  32. Oscier DG, Matutes E, Gardiner A, et al. Cytogenetic studies in splenic lymphoma with villous lymphocytes. Br J Haematol. 1993;85:487–491
  33. Hernandez JM, Garcia JL, Gutierrez NC, et al. Novel genomic imbalances in B-cell splenic marginal zone lymphomas revealed by comparative genomic hybridization and cytogenetics. Am J Pathol. 2001;158:1843–1850
  34. Martin-Subero JI, Ibbotson R, Klapper W, et al. A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation. Leukemia. 2007;21:1532–1544
  35. Chacon JI, Mollejo M, Munoz E, et al. Splenic marginal zone lymphoma: clinical characteristics and prognostic factors in a series of 60 patients. Blood. 2002;100:1648–1654

PII: S0046-8177(09)00354-2

doi: 10.1016/j.humpath.2009.09.007

Human Pathology
Volume 41, Issue 4 , Pages 540-551 , April 2010