Human Pathology
Volume 41, Issue 5 , Pages 679-685 , May 2010

Clinicopathologic study of 53 metaplastic breast carcinomas: their elements and prognostic implications

  • Rin Yamaguchi, MD, PhD

      Affiliations

    • Department of Pathology, Cancer Institute of Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan
    • Department of Pathology, Kurume University School of Medicine, Kurume 830-0001, Japan
    • Corresponding Author InformationCorresponding author. Department of Pathology, Kurume University School of Medicine, Kurume 830-0011, Japan.
    • ,
  • Rie Horii, MD, PhD

      Affiliations

    • Department of Pathology, Cancer Institute of Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan
    • ,
  • Ichiro Maeda, MD, PhD

      Affiliations

    • Department of Pathology, Cancer Institute of Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan
    • ,
  • Sachie Suga, MD

      Affiliations

    • Department of Breast Oncology, Cancer Institute Hospital, Tokyo 135-8550, Japan
    • ,
  • Masujiro Makita, MD, PhD

      Affiliations

    • Department of Breast Oncology, Cancer Institute Hospital, Tokyo 135-8550, Japan
    • ,
  • Takuji Iwase, MD, PhD

      Affiliations

    • Department of Breast Oncology, Cancer Institute Hospital, Tokyo 135-8550, Japan
    • ,
  • Masahiko Oguchi, MD, PhD

      Affiliations

    • Department of Breast Radiation Oncology, Cancer Institute Hospital, Tokyo 135-8550, Japan
    • ,
  • Yoshinori Ito, MD, PhD

      Affiliations

    • Department of Cancer Chemotherapy Center, Cancer Institute Hospital, Tokyo 135-8550, Japan
    • ,
  • Futoshi Akiyama, MD, PhD

      Affiliations

    • Department of Pathology, Cancer Institute of Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan

Received 5 August 2009 ,Revised 1 October 2009 ,Accepted 8 October 2009.

References 

  1. Rosen PP. Rosen's Breast Pathology. In:  Rosen PP editors. Carcinoma with metaplasia. 2nd ed.. Philadelphia: Lippincott-Raven; 2001;p. 425–453
  2. Wargotz ES, Norris HJ. Metaplastic carcinomas of the breast. I. Matrix-producing carcinoma. Hum Pathol. 1989;20:628–635
  3. Wargotz ES, Deos PH, Norris HJ. Metaplastic carcinomas of the breast. II. Spindle cell carcinoma. Hum Pathol. 1989;20:732–740
  4. Wargotz ES, Norris HJ. Metaplastic carcinomas of the breast. III. Carcinosarcoma. Cancer. 1989;64:1490–1499
  5. Wargotz ES, Norris HJ. Metaplastic carcinomas of the breast. IV. Squamous cell carcinoma of ductal origin. Cancer. 1990;65:272–276
  6. Wargotz ES, Norris HJ. Metaplastic carcinomas of the breast: V. Metaplastic carcinoma with osteoclastic giant cells. Hum Pathol. 1990;21:1142–1150
  7. World Health Organization classification of Tumours. In:  Tavassoli FA,  Devilee P editor. Tumours of the breast and female genital organs. Pathology and genetics of tumors of the digestive system. World Health Organization Classification of Tumours. Lyon, France: IARC Press; 2003;p. 37–41
  8. Tse GM, Tan PH, Putti TC, et al. Metaplastic carcinoma of the breast: a clinicopathological review. J Clin Pathol. 2006;59:1079–1083
  9. Oberman HA. Metaplastic carcinoma of the breast. A clinicopathologic study of 29 patients. Am J Surg Pathol. 1987;11:918–929
  10. Sakamoto G, Inaji H, Akiyama F, et al. General rules for clinical and pathological recording of breast cancer. Breast Cancer. 2005;12(Suppl):S1–S27
  11. World Health Organization classification of tumours. In:  Tavassoli FA,  Devilee P editor. Tumours of the breast and female genital organs. Pathology and genetics of tumors of the digestive system. World Health Organization Classification of Tumours. Lyon, France: IARC Press; 2003;p. 100–103
  12. Gobbi H, Simpson JF, Borowsky A, et al. Metaplastic breast tumors with a dominant fibromatosis-like phenotype have a high risk of local recurrence. Cancer. 1999;85:2170–2182
  13. Sneige N, Yaziji H, Mandavilli SR, et al. Low-grade (fibromatosis-like) spindle cell carcinoma of the breast. Am J Surg Pathol. 2001;25:1009–1016
  14. Carter MR, Hornick JL, Lester S, et al. Spindle cell (sarcomatoid) carcinoma of the breast: a clinicopathologic and immunohistochemical analysis of 29 cases. Am J Surg Pathol. 2006;30:300–309
  15. Davis WG, Hennessy B, Babiera G, et al. Metaplastic sarcomatoid carcinoma of the breast with absent or minimal overt invasive carcinomatous component: a misnomer. Am J Surg Pathol. 2005;29:1456–1463
  16. Grenier J, Soria JC, Mathieu MC, et al. Differential immunohistochemical and biological profile of squamous cell carcinoma of the breast. Anticancer Res. 2007;27:547–555
  17. Chhieng C, Cranor M, Lesser ME, et al. Metaplastic carcinoma of the breast with osteocartilaginous heterologous elements. Am J Surg Pathol. 1998;22:188–194
  18. Downs-Kelly E, Nayeemuddin KM, Albarracin C, et al. Matrix-producing carcinoma of the breast: an aggressive subtype of metaplastic carcinoma. Am J Surg Pathol. 2009;33:534–541
  19. Luini A, Aguilar M, Gatti G, et al. Metaplastic carcinoma of the breast, an unusual disease with worse prognosis: the experience of European Institute of Oncology and review of the literature. Breast Cancer Res Treat. 2007;101:349–353
  20. Pezzi CM, Patel-Parekh L, Cole K, et al. Characteristics and treatment of metaplastic breast cancer: analysis of 892 cases from the national cancer data base. Ann Surg Oncol. 2007;14:166–173

PII: S0046-8177(09)00374-8

doi: 10.1016/j.humpath.2009.10.009

Human Pathology
Volume 41, Issue 5 , Pages 679-685 , May 2010

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