Human Pathology
Volume 41, Issue 4 , Pages 594-601 , April 2010

Clear cell adenocarcinoma of the bladder and urethra: cases diffusely mimicking nephrogenic adenoma

  • Mehsati Herawi, MD, PhD

      Affiliations

    • Department of Pathology, Harper University Hospital, Wayne State University School of Medicine, and Karmanos Cancer Institute, Detroit, MI 48201, USA
    • ,
  • Peter A. Drew, MD

      Affiliations

    • University of Florida, Gainesville, FL, USA
    • ,
  • Chin-Chen Pan, MD

      Affiliations

    • Veterans General Hospital, Taipei, Taiwan
    • ,
  • Jonathan I. Epstein, MD

      Affiliations

    • The Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    • Corresponding Author InformationCorresponding author.

Received 10 September 2009 ,Revised 6 October 2009 ,Accepted 15 October 2009.

References 

  1. Alsanjari N, Lynch MJ, Fisher C, Parkinson MC. Vesical clear cell adenocarcinoma. V. Nephrogenic adenoma: a diagnostic problem. Histopathology. 1995;27:43–49
  2. Drew PA, Murphy WM, Civantos F, Speights VO. The histogenesis of clear cell adenocarcinoma of the lower urinary tract. Case series and review of the literature. Hum Pathol. 1996;27:248–252
  3. Gilcrease MZ, Delgado R, Vuitch F, Albores-Saavedra J. Clear cell adenocarcinoma and nephrogenic adenoma of the urethra and urinary bladder: a histopathologic and immunohistochemical comparison. Hum Pathol. 1998;29:1451–1456
  4. Oliva E, Young RH. Clear cell adenocarcinoma of the urethra: a clinicopathologic analysis of 19 cases. Mod Pathol. 1996;9:513–520
  5. Young RH, Scully RE. Clear cell adenocarcinoma of the bladder and urethra. A report of three cases and review of the literature. Am J Surg Pathol. 1985;9:816–826
  6. Ingram EA, DePauw P. Adenocarcinoma of the male urethra with associated nephrogen metaplasia. Case report and review of the literature. Cancer. 1985;55:160–164
  7. Oliva E, Young RH. Nephrogenic adenoma of the urinary tract: a review of the microscopic appearance of 80 cases with emphasis on unusual features. Mod Pathol. 1995;8:722–730
  8. Signori G, Tonini G, Aulenti V, et al. Clear cell adenocarcinoma of the bladder in a male patient: clinicopathologic analysis of a case. Urol Int. 2003;71:228–230
  9. Oliva E, Amin MB, Jimenez R, Young RH. Clear cell carcinoma of the urinary bladder: a report and comparison of four tumors of müllerian origin and nine of probable urothelial origin with discussion of histogenesis and diagnostic problems. Am J Surg Pathol. 2002;26:190–197
  10. Schultz RE, Bloch MJ, Tomaszewski JE, et al. Mesonephric adenocarcinoma of the bladder. J Urol. 1984;132:263–265
  11. Rodriguez-Montes CE, Alvarado-Cabrero I. Nephrogenic adenoma of the urinary bladder. A lesion that can be confused with carcinoma. Report of 4 cases. Gac Med Mex. 2001;137:67–72
  12. Malpica A, Ro JY, Troncoso P, et al. Nephrogenic adenoma of the prostatic urethra involving the prostate gland: a clinicopathologic and immunohistochemical study of eight cases. Hum Pathol. 1994;25:390–395
  13. Young RH, Scully RE. Nephrogenic adenoma. A report of 15 cases, review of the literature, and comparison with clear cell adenocarcinoma of the urinary tract. Am J Surg Pathol. 1986;10:268–275
  14. Seseke F, Zoller G, Kunze E. Clear cell adenocarcinoma of the male urethra in association with so-called nephrogenic metaplasia. Urol Int. 2001;67:104–108
  15. Sung M, Zhang S, MacLennan GT, et al. Histogenesis of clear cell adenocarcinoma in the urinary tract: Evidence of urothelial origin. Clin Cancer Res. 2008;14:1947–1955
  16. Murphy DP, Pantuck AJ, Amenta PS, et al. Female urethral adenocarcinoma: immunohistochemical evidence of more than 1 tissue of origin. J Urol. 1999;161:1881–1884
  17. Ordi J, Nogales FF, Palacin A, et al. Mesonephric adenocarcinoma of the uterine corpus. CD10 expression as evidence of mesonephric differentiation. Am J Surg Pathol. 2001;25:1540–1545
  18. Balat O, Kudelka AP, Edwards CL, et al. Malignant transformation in endometriosis of the urinary bladder: case report of clear cell adenocarcinoma. Eur J Gynaecol Oncol. 1996;17:13–16
  19. Mai KT, Yazdi HM, Perkins DG, et al. Multicentric clear cell adenocarcinoma in the urinary bladder and the urethral diverticulum: evidence of origin of clear cell adenocarcinoma of the female lower urinary tract from Müllerian duct remnants. Histopathology. 2000;36:380–382
  20. Porcaro AB, D'Amico A, Ficarra V, et al. Nephrogenic adenoma of the urinary bladder: Our experience and review of the literature. Urol Internat. 2001;166:152–155
  21. Pycha A, Main C, Reiter WJ, et al. Nephrogenic adenoma in renal transplant recipients: A truly benign lesion?. Urology. 1998;52:756–761
  22. Cheng L, Cheville JC, Sebo TJ, et al. Atypical nephrogenic metaplasia of the urinary tract: a precursor lesion?. Cancer. 2000;88:853–861
  23. Tong GX, Melamed J, Mansukhani M, et al. PAX2: a reliable marker for nephrogenic adenoma. Mod Pathol. 2006;19:356–363
  24. Hartmann A, Junker K, Dietmaier W, et al. Molecular evidence for progression of nephrogenic metaplasia of the urinary bladder to clear cell adenocarcinoma. Hum Pathol. 2006;37:117–120
  25. Skinnider BF, Oliva E, Young RH, Amin MB. Expression of alpha-methylacyl-CoA racemase (P504S) in nephrogenic adenoma: a significant immunohistochemical pitfall compounding the differential diagnosis with prostatic adenocarcinoma. Am J Surg Pathol. 2004;28:701–705
  26. Mazal PR, Schaufler R, Altenhuber-Muller R, et al. Derivation of nephrogenic adenomas from tubular cells in kidney-transplant recipients. N Engl J Med. 2002;29:653–659

PII: S0046-8177(09)00376-1

doi: 10.1016/j.humpath.2009.10.011

Human Pathology
Volume 41, Issue 4 , Pages 594-601 , April 2010

Article Tools

* Image Usage & Resolution