Human Pathology
Volume 41, Issue 4 , Pages 602-604 , April 2010

Candida albicans–associated necrotizing vasculitis producing life-threatening gastrointestinal hemorrhage

  • Jeremy Sargent, MD

      Affiliations

    • Department of Hematology, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland
    • ,
  • Aengus O'Marcaigh, MD

      Affiliations

    • Department of Hematology, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland
    • ,
  • Owen Smith, MD

      Affiliations

    • Department of Hematology, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland
    • ,
  • Karina Butler, MD

      Affiliations

    • Department of Infectious Disease, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland
    • ,
  • Patrick Gavin, MD

      Affiliations

    • Department of Infectious Disease, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland
    • ,
  • Maureen O’Sullivan, MD, PhD

      Affiliations

    • Department of Pathology, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland
    • Corresponding Author InformationCorresponding author.

Received 21 July 2009 ,Revised 1 September 2009 ,Accepted 15 September 2009.

References 

  1. Gözdaşoĝlu S, Ertem M, Büyükkeçeci Z, et al. Fungal infection and colonization in children with acute leukemia and lymphoma during induction therapy. Med Pediatr Oncol. 1999;32:344–348[PMID: 10219335]
  2. Rubnitz JE, Lensing S, Zhou Y, et al. Death during induction therapy and first remission of acute leukemia in childhood. The St Jude Experience. Cancer. 2004;101:1677–1684
  3. Wheeler K, Chessells JM, Bailey CC, Richards SM. Treatment related deaths during induction and in first remission in acute lymphoblastic leukemia: MRC UKALL X. Arch Dis Child. 1996;74:101–107
  4. Mantadakis E, Danilatou V, Stiakaki E, Kalmanti M. Infectious toxicity of dexamethasone during ALL remission induction chemotherapy: report of two cases and literature review. Pediatr Hematol Oncol. 2004;21:27–35
  5. Rabah R, Kupsky WJ, Haas JE. Arteritis and fatal subarachnoid hemorrhage complicating occult candida meningitis: unusual presentation in pediatric acquired immunodeficiency syndrome. Arch Pathol Lab Med. 1998;122:1030–1033
  6. Chapuis-Taillard C, Manuel O, Bille J, Calandra T, Rotman S, Tarr PE. Candida arteritis in patients who have not received organ transplants: case report and review of the literature. Clin Infect Dis. 2008;46:e106–e111
  7. Gregory RK, Powles RL, Treleaven JG, et al. Systemic candidiasis with candida vasculitis due to Candida kruzei in a patient with acute myeloid leukemia. Bone Marrow Transplant. 1999;23:103–104
  8. Hirata N, Ishibashi K, Ohta S, et al. Histopathological examination and analysis of mortality in DBA/2 mouse vasculitis induced with CAWS, a water-soluble extracellular polysaccharide fraction obtained from Candida albicans. [Article in Japanese] Yakugaku Zasshi. 2006;126:643–650
  9. Oharaseki T, Kameoka Y, Kura F, Persad AS, Suzuki K, Naoe S. Susceptibility loci to coronary arteritis in animal model of Kawasaki disease induced with Candida albicans-derived substances. Microbiol Immunol. 2005;49:181–189
  10. Ishida-Okawara A, Nagi-Miura N, Oharaseki T, et al. Neutrophil activation and arteritis induced by C albicans water-soluble mannoprotein-beta-glucan complex (CAWS). Exp Mol Pathol. 2007;82:220–226

PII: S0046-8177(09)00404-3

doi: 10.1016/j.humpath.2009.09.015

Human Pathology
Volume 41, Issue 4 , Pages 602-604 , April 2010

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