Human Pathology
Volume 41, Issue 4 , Pages 615-616 , April 2010

Anaplastic lymphoma kinase 1 detected by immunohistochemistry in non–small cell lung cancer: a promising feature?—reply

References 

  1. Boland JM, Erdogan S, Vasmatzis G, et al. Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcriptional up-regulation in non–small cell lung carcinomas. Hum Pathol. 2009;40:1152–1158
  2. Martelli MP, Sozzi G, Hernandez L, et al. EML4-ALK rearrangement in non–small cell lung cancer and non-tumor lung tissues. Am J Pathol. 2009;174:661–670
  3. Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non–small-cell lung cancer. Nature. 2007;448:561–566
  4. Horn L, Pao W. EML4-ALK: honing in on a new target in non–small-cell lung cancer. J Clin Oncol. 2009;27:4232–4235
  5. Soda M, Takada S, Takeuchi K, et al. A mouse model for EML4-ALK–positive lung cancer. Proc Natl Acad Sci U S A. 2008;105:19893–19897
  6. Morris SW, Kirstein MN, Valentine MB, et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science. 1995;267:316–317
  7. Lawrence B, Perez-Atayde A, Hibbard MK, et al. TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. Am J Pathol. 2000;157:377–384
  8. Chen Y, Takita J, Choi YL, et al. Oncogenic mutations of ALK kinase in neuroblastoma. Nature. 2008;455:971–974
  9. Pulford K, Lamant L, Morris SW, et al. Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1. Blood. 1997;89:1394–1404
  10. Inamura K, Takeuchi K, Togashi Y, et al. EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers. J Thorac Oncol. 2008;3:13–17
  11. Wong DW, Leung EL, So KK, et al. The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS. Cancer. 2009;115:1723–1733
  12. Takeuchi K, Choi YL, Togashi Y, et al. KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer. Clin Cancer Res. 2009;15:3143–3149
  13. Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non–small-cell lung cancer who harbor EML4-ALK. J Clin Oncol. 2009;27:4247–4253

PII: S0046-8177(09)00428-6

doi: 10.1016/j.humpath.2009.11.010

Human Pathology
Volume 41, Issue 4 , Pages 615-616 , April 2010