Human Pathology
Volume 41, Issue 5 , Pages 763-767 , May 2010

Infantile hemangioendothelioma with elevated serum α fetoprotein: report of 2 cases with immunohistochemical analysis

  • Tae-Jung Kim, MD, PhD

      Affiliations

    • Department of Hospital Pathology, College of Medicine, the Catholic University of Korea, 150-713 Seoul, Korea
    • ,
  • Youn Soo Lee, MD, PhD

      Affiliations

    • Department of Hospital Pathology, College of Medicine, the Catholic University of Korea, 150-713 Seoul, Korea
    • Corresponding Author InformationCorresponding author.
    • ,
  • Young Soo Song, MD

      Affiliations

    • Department of Pathology, College of Medicine, Hanyang University, 133-792 Seoul, Korea
    • ,
  • Chan Kum Park, MD, PhD

      Affiliations

    • Department of Pathology, College of Medicine, Hanyang University, 133-792 Seoul, Korea
    • ,
  • Sang In Shim, MD, PhD

      Affiliations

    • Department of Hospital Pathology, College of Medicine, the Catholic University of Korea, 150-713 Seoul, Korea
    • ,
  • Chang Suk Kang, MD, PhD

      Affiliations

    • Department of Hospital Pathology, College of Medicine, the Catholic University of Korea, 150-713 Seoul, Korea
    • ,
  • Kyo-Young Lee, MD, PhD

      Affiliations

    • Department of Hospital Pathology, College of Medicine, the Catholic University of Korea, 150-713 Seoul, Korea

Received 6 March 2009 ,Revised 23 April 2009 ,Accepted 13 May 2009.

References 

  1. Mortele KJ, Vanzieleghem B, Mortele B, Benoit Y, Ros PR. Solitary hepatic infantile hemangioendothelioma: dynamic gadolinium-enhanced MR imaging findings. Eur Radiol. 2002;12:862–865
  2. Lunetta P, Karikoski R, Penttila A, Sajantila A. Sudden death associated with a multifocal type II hemangioendothelioma of the liver in a 3-month-old infant. Am J Forensic Med Pathol. 2004;25:56–59
  3. Boon LM, Burrows PE, Paltiel HJ, et al. Hepatic vascular anomalies in infancy: a twenty-seven-year experience. J Pediatr. 1996;129:346–354
  4. Selby DM, Stocker JT, Waclawiw MA, Hitchcick CL, Ishak KG. Infantile hemangioendothelioma of the liver. Hepatology. 1994;20:39–45
  5. Urbach AH, Zitelli BJ, Blatt J, Gartner JC, Malatack JJ. Elevated alpha-fetoprotein in a neonate with a benign hemangioendothelioma of the liver. Pediatrics. 1987;80:596–597
  6. Seo IS, Min KW, Mirkin LD. Hepatic hemangioendothelioma of infancy associated with elevated alpha fetoprotein and catecholamine by-products. Pediatr Pathol. 1988;8:625–631
  7. Lehrnbecher T, Frauendienst-Egger G, Schrod L, Marx A, Harms D, von Stockhausen HB. Haemangioendothelioma in a preterm infant associated with highly elevated alpha-fetoprotein. Eur J Pediatr. 1996;155:423–424
  8. Han SJ, Tsai CC, Tsai HM, Chen YJ. Infantile hemangioendothelioma with a highly elevated serum alpha-fetoprotein level. Hepatogastroenterology. 1998;45:459–461
  9. Herman TE, Siegel MJ. Solitary hepatic hemangioendothelioma with extensive cystic necrosis and markedly elevated alpha-fetoprotein. J Perinatol. 2001;21:568–570
  10. Sari N, Yalcin B, Akyuz C, Haliloglu M, Buyukpamukcu M. Infantile hepatic hemangioendothelioma with elevated serum alpha-fetoprotein. Pediatr Hematol Oncol. 2006;23:639–647
  11. Riley MR, Garcia MG, Cox KL, Berquist WE, Kerner JA. Hepatic infantile hemangioendothelioma with unusual manifestations. J Pediatr Gastroenterol Nutr. 2006;42:109–113
  12. Wu JT, Book L, Sudar K. Serum alpha fetoprotein (AFP) levels in normal infants. Pediatr Res. 1981;15:50–52
  13. Chan YF, Choi AC, MA L, Leung MP. Infantile hemangioendothelioma of the liver: ultrastructural study of a type II case. Pathology. 1986;18:463–468

PII: S0046-8177(09)00431-6

doi: 10.1016/j.humpath.2009.05.019

Human Pathology
Volume 41, Issue 5 , Pages 763-767 , May 2010

Article Tools

* Image Usage & Resolution