Human Pathology
Volume 41, Issue 6 , Pages 859-866 , June 2010

Decreased expression of focal adhesion kinase is associated with a poor prognosis in extrahepatic bile duct carcinoma

  • Akifumi Hayashi, MD

      Affiliations

    • Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  • ,
  • Shinichi Aishima, MD, PhD

      Affiliations

    • Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    • Corresponding Author InformationCorresponding author.
  • ,
  • Takahiro Inoue, MD, PhD

      Affiliations

    • Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  • ,
  • Kohei Nakata, MD, PhD

      Affiliations

    • Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  • ,
  • Katsuya Morimatsu, MD

      Affiliations

    • Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  • ,
  • Eishi Nagai, MD, PhD

      Affiliations

    • Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  • ,
  • Yoshinao Oda, MD, PhD

      Affiliations

    • Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  • ,
  • Masao Tanaka, MD, PhD

      Affiliations

    • Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  • ,
  • Masazumi Tsuneyoshi, MD, PhD

      Affiliations

    • Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan

Received 31 July 2009 ,Revised 11 September 2009 ,Accepted 18 September 2009.

References 

  1. Patel T. Cholangiocarcinoma. Nat Clin Pract Gastroenterol Hepatol. 2006;3:33–42
  2. Michaud DS. The epidemiology of pancreatic, gallbladder, and other biliary tract cancers. Gastrointest Endosc. 2002;56:S195–S200
  3. Shimonishi T, Sasaki M, Nakanuma Y. Precancerous lesions of intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Surg. 2000;7:542–550
  4. Verslype C, Prenen H, Van Cutsem E. The role of chemotherapy in biliary tract carcinoma. HPB (Oxford). 2008;10:164–167
  5. Schaller MD, Borgman CA, Cobb BS, et al. pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci U S A. 1992;89:5192–5196
  6. Schaller MD, Hildebrand JD, Shannon JD, et al. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol. 1994;14:1680–1688
  7. Xing Z, Chen HC, Nowlen JK, et al. Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain. Mol Biol Cell. 1994;5:413–421
  8. Chen HC, Guan JL. Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A. 1994;91:10148–10152
  9. Zhang X, Chattopadhyay A, Ji QS, et al. Focal adhesion kinase promotes phospholipase C-gamma1 activity. Proc Natl Acad Sci U S A. 1999;96:9021–9026
  10. Han DC, Guan JL. Association of focal adhesion kinase with Grb7 and its role in cell migration. J Biol Chem. 1999;274:24425–24430
  11. Cance WG, Harris JE, Iacocca MV, et al. Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res. 2000;6:2417–2423
  12. Miyazaki T, Kato H, Nakajima M, et al. FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma. Br J Cancer. 2003;89:140–145
  13. Kim SJ, Park JW, Yoon JS, et al. Increased expression of focal adhesion kinase in thyroid cancer: immunohistochemical study. J Korean Med Sci. 2004;19:710–715
  14. Sood AK, Coffin JE, Schneider GB, et al. Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion. Am J Pathol. 2004;165:1087–1095
  15. Carelli S, Zadra G, Vaira V, et al. Up-regulation of focal adhesion kinase in non-small cell lung cancer. Lung Cancer. 2006;53:263–271
  16. Itoh S, Maeda T, Shimada M, et al. Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma. Clin Cancer Res. 2004;10:2812–2817
  17. Gabriel B, zur Hausen A, Stickeler E, et al. Weak expression of focal adhesion kinase (pp125FAK) in patients with cervical cancer is associated with poor disease outcome. Clin Cancer Res. 2006;12:2476–2483
  18. Ohta R, Yamashita Y, Taketomi A, et al. Reduced expression of focal adhesion kinase in intrahepatic cholangiocarcinoma is associated with poor tumor differentiation. Oncology. 2006;71:417–422
  19. Nakanishi Y, Zen Y, Kondo S, et al. Expression of cell cycle-related molecules in biliary premalignant lesions: biliary intraepithelial neoplasia and biliary intraductal papillary neoplasm. Hum Pathol. 2008;39:1153–1161
  20. Japanese Society of Biliary Surgery. General Rules for Surgical and Pathological Studies on Cancer of the Biliary Tract. 5th ed.. Tokyo: Kanehara Shuppan; 2003;
  21. Albores-Saavedra J, Henson DE, Klimstra DS. Tumors of the gallbladder, extrahepatic bile ducts and ampulla of Vater. In:  Rosai J editors. Atlas of tumor pathology, 3rd series. Washington: Armed Forces Institute of Pathology; 2000;
  22. Albores-Saavedra J, Scoazec JC, Wittekind C, et al. Carcinoma of the gallbladder and extrahepatic bile duct. In:  Hamilton SR,  Aaltonen LA editor. World Health Organization classification of tumours. Lyon: Tumours of the Digestive System. IARC Press; 2000;p. 206–214
  23. Wakai T, Shirai Y, Moroda T, et al. Impact of ductal resection margin status on long-term survival in patients undergoing resection for extrahepatic cholangiocarcinoma. Cancer. 2005;103:1210–1216
  24. Hong SM, Cho H, Lee OJ, et al. The number of metastatic lymph nodes in extrahepatic bile duct carcinoma as a prognostic factor. Am J Surg Pathol. 2005;29:1177–1183
  25. Hong SM, Kim MJ, Cho H, et al. Superficial vs deep pancreatic parenchymal invasion in the extrahepatic bile duct carcinomas: a significant prognostic factor. Mod Pathol. 2005;18:969–975
  26. Hong SM, Hwang I, Song DE, et al. Clinical and prognostic significances of nuclear and cytoplasmic KIT expressions in extrahepatic bile duct carcinomas. Mod Pathol. 2007;20:562–569
  27. Yoshikawa D, Ojima H, Iwasaki M, et al. Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma. Br J Cancer. 2008;98:418–425
  28. Murakami S, Miyamoto M, Hida Y, et al. Caveolin-I overexpression is a favourable prognostic factor for patients with extrahepatic bile duct carcinoma. Br J Cancer. 2003;88:1234–1238
  29. Tamada S, Shibahara H, Higashi M, et al. MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma. Clin Cancer Res. 2006;12:4257–4264
  30. Lu Z, Jiang G, Blume-Jensen P, et al. Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. Mol Cell Biol. 2001;21:4016–4031
  31. Yano H, Mazaki Y, Kurokawa K, et al. Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion. J Cell Biol. 2004;166:283–295
  32. Kallergi G, Agelaki S, Markomanolaki H, et al. Activation of FAK/PI3K/Rac1 signaling controls actin reorganization and inhibits cell motility in human cancer cells. Cell Physiol Biochem. 2007;20:977–986
  33. Schaller MD. FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?. J Cell Biol. 2004;166:157–159
  34. Moissoglu K, Gelman IH. v-Src rescues actin-based cytoskeletal architecture and cell motility and induces enhanced anchorage independence during oncogenic transformation of focal adhesion kinase-null fibroblasts. J Biol Chem. 2003;278:47946–47959
  35. Ayaki M, Komatsu K, Mukai M, et al. Reduced expression of focal adhesion kinase in liver metastases compared with matched primary human colorectal adenocarcinomas. Clin Cancer Res. 2001;7:3106–3112

PII: S0046-8177(09)00434-1

doi: 10.1016/j.humpath.2009.09.018

Human Pathology
Volume 41, Issue 6 , Pages 859-866 , June 2010