« Previous
Next »
Human Pathology
Volume 41, Issue 6
, Pages 886-894
, June 2010
Oncogenic BRAF-positive dysplastic nevi and the tumor suppressor IGFBP7—challenging the concept of dysplastic nevi as precursor lesions?
References
- . Patterns of familial aggregation of three melanoma risk factors: great number of naevi, light phototype and high degree of sun exposure. Int J Epidemiol. 2000;29:408–415
- A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma. Hum Pathol. 1984;15:1147–1165
- . Melanocytic dysplastic naevi occupy the middle ground between benign melanocytic naevi and cutaneous malignant melanomas: emerging clues. J Clin Pathol. 2005;58:453–456
- Clinically recognized dysplastic nevi. A central risk factor for cutaneous melanoma. JAMA. 1997;18:1439–1444
- Management of cutaneous malignant melanoma by dermatologists of the American Academy of Dermatology. I. Survey of biopsy practices of pigmented lesions suspected as melanoma. J Am Acad Dermatol. 1995;33:441–450
- . Melanoma risk in individuals with clinically atypical nevi. Arch Dermatol. 1994;130:999–1001
- . Dysplastic nevi. N Engl J Med. 2003;349:2233–2240
- Dysplastic naevi with moderate to severe histological dysplasia: a risk factor for melanoma. Br J Dermatol. 2006;155:988–993
- High frequency of BRAF mutations in nevi. Nat Genet. 2003;33:19–20
- BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma. Cancer Res. 2003;63:3883–3885
- . BRAF kinase gene V599E mutation in growing melanocytic lesions. J Invest Dermatol. 2004;123:733–736
- . Detection of the BRAF V600E mutation in melanocytic lesions using the ligase detection reaction. J Cutan Pathol. 2005;32:334–339
- BRAF as a melanoma susceptibility candidate gene?. Cancer Res. 2003;63:3061–3065
- . Frequencies of NRAS and BRAF mutations increase from the radial to the vertical growth phase in cutaneous melanoma. J Invest Dermatol. 2009;129:1483–1488
- . BRAF mutations are common somatic events in melanocytic nevi. J Invest Dermatol. 2004;122:342–348
- . Lack of association between BRAF mutation and MAPK ERK activation in melanocytic nevi. J Invest Dermatol. 2006;126:161–166
- . Proliferative activity of primary cutaneous melanocytic tumours. Virchows Arch A Pathol Anat Histopathol. 1993;423:359–364
- . Human melanocyte senescence and melanoma susceptibility genes. Oncogene. 2003;22:3063–3069
- . Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell. 2008;132:363–374
- DNA repair, dysplastic nevi, and sunlight sensitivity in the development of cutaneous malignant melanoma. J Natl Cancer Inst. 2002;94:94–101
- . N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin. J Invest Dermatol. 1998;111:757–761
- Exon 15 BRAF mutations are uncommon in melanomas arising in non–sun-exposed sites. Clin Cancer Res. 2004;10:3444–3447
- . Genetic pathways to melanoma tumorigenesis. J Clin Pathol. 2004;57:797–801
- . Identification of novel deletion loci at 1p36 and 9p22-21 in melanocytic dysplastic and cutaneous malignant melanomas. Arch Dermatol. 2003;139:816–817
- Mutations of the BRAF gene in human cancer. Nature. 2002;417:949–954
- Analysis of ras oncogenes in malignant melanoma and precursor lesions: correlation of point mutations with differentiation phenotype. Oncogene. 1989;4:1363–1374
- . Screening of N-ras codon 61 mutations in paired primary and metastatic cutaneous melanomas: mutations occur early and persist throughout tumor progression. Clin Cancer Res. 2002;8:3468–3474
- . Frequency of UV-inducible NRAS mutations in melanomas of patients with germline CDKN2A mutations. J Natl Cancer Inst. 2003;95:790–798
- . BRAF mutation—a frequent event in benign, atypical and malignant melanocytic lesions of the skin. Am J Dermatopathol. 2003;25:365–370
- Mutations of the BRAF gene in benign and malignant melanocytic lesions. J Invest Dermatol. 2003;121:1160–1162
- Method of mutation analysis may contribute to discrepancies in reports of V599EBRAF mutation frequencies in melanocytic neoplasms. J Invest Dermatol. 2004;123:990–992
- . Mutational analysis of the BRAF gene in human congenital and dysplastic melanocytic naevi. Melanoma Res. 2005;15:401–407
- . Distribution of BRAF T1799A(V600E) mutations across various types of benign nevi: implications for melanocytic tumorigenesis. Am J Dermatopathol. 2007;29:534–537
- High frequency of BRAFV600E mutation in acquired nevi and small congenital nevi, but low frequency of mutation in medium-sized congenital nevi. J Invest Dermatol. 2006;126:2111–2118
- Differential oncogenic potential of activated RAS isoforms in melanocytes. Oncogene. 2007;26:4563–4570
- . Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations. J Invest Dermatol. 2007;127:179–182
- . Acticated ras—yet another player in melanoma?. Am J Pathol. 1996;149:739–744
- . Diagnostic assessment of two novel proliferation-specific antigens in benign and malignant melanocytic lesions. Am J Pathol. 1995;147:1615–1625
- . Comparison of pHH3, Ki-67, and survivin immunoreactivity in benign and malignant melanocytic lesions. Am J Dermatopathol. 2008;30:117–122
- . The significance of Ki-67 proliferative index and cyclin D1 expression of dysplastic nevi in the biologic spectrum of melanocytic lesions. Appl Immunohistochem Mol Morphol. 2007;15:160–164
- . Cytological atypia does not equal malignancy: an old but unappreciated truth. J Cutan Pathol. 2009;36:1014–1021
- . Ras mutations in human melanocytic lesions: K-ras activation is a frequent and early event in melanoma development. Oncogene Res. 1989;5:121–127
- N-ras mutation in human cutaneous melanoma from sun-exposed body sites. Mol Cell Biol. 1989;9:3114–3116
- . RAS mutations in human melanoma: a marker of malignant progression. J Invest Dermatol. 1994;102:285–290
PII: S0046-8177(09)00453-5
doi: 10.1016/j.humpath.2009.12.002
© 2010 Elsevier Inc. All rights reserved.
« Previous
Next »
Human Pathology
Volume 41, Issue 6
, Pages 886-894
, June 2010
