Human Pathology
Volume 41, Issue 9 , Pages 1231-1237 , September 2010

Enteropathy-associated T-cell lymphoma—a clinicopathologic and array comparative genomic hybridization study

  • Young Hyeh Ko, MD, PhD

      Affiliations

    • Department of Pathology, Samsung Medical Center, Sungkyunkwan University, Seoul 135-710, Korea
    • Corresponding Author InformationCorresponding authors. Young Hyeh Ko is to be contacted at Department of Pathology, Samsung Medical Center, Sungkyunkwan University, Kangnamgu, Seoul, 135-710, Korea. Masao Seto, Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.
    • ,
  • Sivasundaram Karnan

      Affiliations

    • Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan
    • ,
  • Kyeong Mee Kim, MD, PhD

      Affiliations

    • Department of Pathology, Samsung Medical Center, Sungkyunkwan University, Seoul 135-710, Korea
    • ,
  • Cheol Keun Park, MD, PhD

      Affiliations

    • Department of Pathology, Samsung Medical Center, Sungkyunkwan University, Seoul 135-710, Korea
    • ,
  • Eun Suk Kang, MD, PhD

      Affiliations

    • Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University, Seoul 135-710, Korea
    • ,
  • Young Ho Kim, MD, PhD

      Affiliations

    • Division of Gastroenterology, Samsung Medical Center, Sungkyunkwan University, Seoul 135-710, Korea
    • ,
  • Won Ki Kang, MD, PhD

      Affiliations

    • Division of Gastroenterology, Samsung Medical Center, Sungkyunkwan University, Seoul 135-710, Korea
    • ,
  • Seok Jin Kim, MD, PhD

      Affiliations

    • Hemato-oncology of Internal Medicine, Samsung Medical Center, Sungkyunkwan University, Seoul 135-710, Korea
    • ,
  • Won Seog Kim, MD, PhD

      Affiliations

    • Hemato-oncology of Internal Medicine, Samsung Medical Center, Sungkyunkwan University, Seoul 135-710, Korea
    • ,
  • Woo Yong Lee, MD, PhD

      Affiliations

    • General surgery, Samsung Medical Center, Sungkyunkwan University, Seoul 135-710, Korea
    • ,
  • Ho Kyung Chun

      Affiliations

    • General surgery, Samsung Medical Center, Sungkyunkwan University, Seoul 135-710, Korea
    • ,
  • Masao Seto, MD, PhD

      Affiliations

    • Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan
    • Corresponding Author InformationCorresponding authors. Young Hyeh Ko is to be contacted at Department of Pathology, Samsung Medical Center, Sungkyunkwan University, Kangnamgu, Seoul, 135-710, Korea. Masao Seto, Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.

Received 13 July 2009 ,Revised 9 November 2009 ,Accepted 20 November 2009.

References 

  1. Isaacson PG, Chott A, Ott G. Enteropathy-associated T-cell lymphoma. In:  Swerdlow SH,  Campo E,  Harris NL,  Jaffe ES,  Pileri SA,  Stein H,  Thiele J,  Vardiman JW editor. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC; 2008;p. 289–291
  2. Isaacson PG, Du MQ. Gastrointestinal lymphoma: where morphology meets molecular biology. J Pathol. 2005;205:255–274
  3. Zettl A, deLeeuw R, Haralambieva E, Mueller-Hermelink HK. Enteropathy-type T-cell lymphoma. Am J Clin Pathol. 2007;127:701–706
  4. Deleeuw RJ, Zettl A, Klinker E, et al. Whole-genome analysis and HLA genotyping of enteropathy-type T-cell lymphoma reveals 2 distinct lymphoma subtypes. Gastroenterology. 2007;132:1902–1911
  5. Chott A, Haedicke W, Mosberger I, et al. Most CD56+ intestinal lymphomas are CD8+CD5− T-cell lymphomas of monomorphic small to medium size histology. Am J Pathol. 1998;153:1483–1490
  6. Chott A, Vesely M, Simonitsch I, Mosberger I, Hanak H. Classification of intestinal T-cell neoplasms and their differential diagnosis. Am J Clin Pathol. 1999;111:S68–74
  7. Makishima H, Komiyama Y, Asano N, Momose K, Nakamura S, Ishida F. Peripheral T-cell lymphoma following diffuse large B-cell lymphoma associated with celiac disease. Intern Med. 2008;47:295–298
  8. Tagawa H, Tsuzuki S, Suzuki R, et al. Genome-wide array-based comparative genomic hybridization of diffuse large B-cell lymphoma: comparison between CD5-positive and CD5-negative cases. Cancer Res. 2004;64:5948–5955
  9. Ota A, Tagawa H, Karnan S, et al. Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. Cancer Res. 2004;64:3087–3095
  10. Cataldo F, Montalto G. Celiac disease in the developing countries: a new and challenging public health problem. World J Gastroenterol. 2007;13:2153–2159
  11. Freeman HJ. Biopsy-defined adult celiac disease in Asian-Canadians. Can J Gastroenterol. 2003;17:433–436
  12. Han SH, Lee OY, Eun CS, et al. A case of protein-losing enteropathy associated with small bowel villous atrophy. Korean J Gastroenterol. 2007;49:31–36
  13. Makishima H, Ito T, Kodama R, et al. Intestinal diffuse large B-cell lymphoma associated with celiac disease: a Japanese case. Int J Hematol. 2006;83:63–65
  14. Wolters VM, Wijmenga C. Genetic background of celiac disease and its clinical implications. Am J Gastroenterol. 2008;103:190–195
  15. Lee KW, Oh DH, Lee C, Yang SY. Allelic and haplotypic diversity of HLA-A, -B, -C, -DRB1, and -DQB1 genes in the Korean population. Tissue Antigens. 2005;65:437–447
  16. Saito S, Ota S, Yamada E, Inoko H, Ota M. Allele frequencies and haplotypic associations defined by allelic DNA typing at HLA class I and class II loci in the Japanese population. Tissue Antigens. 2000;56:522–529
  17. Al-Toma A, Goerres MS, Meijer JW, Pena AS, Crusius JB, Mulder CJ. Human leukocyte antigen-DQ2 homozygosity and the development of refractory celiac disease and enteropathy-associated T-cell lymphoma. Clin Gastroenterol Hepatol. 2006;4:315–319
  18. Tung CL, Hsieh PP, Chang JH, Chen RS, Chen YJ, Wang JS. Intestinal T-cell and natural killer-cell lymphomas in Taiwan with special emphasis on 2 distinct cellular types: natural killer-like cytotoxic T cell and true natural killer cell. Hum Pathol. 2008;39:1018–1025
  19. Zettl A, Ott G, Makulik A, et al. Chromosomal gains at 9q characterize enteropathy-type T-cell lymphoma. Am J Pathol. 2002;161:1635–1645
  20. Yin MJ, Shao L, Voehringer D, Smeal T, Jallal B. The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. J Biol Chem. 2003;278:52454–52460
  21. Cejkova P, Zettl A, Baumgartner AK, et al. Amplification of NOTCH1 and ABL1 gene loci is a frequent aberration in enteropathy-type T-cell lymphoma. Virchows Arch. 2005;446:416–420

☆ The authors have no conflict of interest to disclosure.

☆☆ This work was supported by a grant from Samsung Biomedical Research Institute, Seoul, Korea (SBRI C-A8-202).

PII: S0046-8177(10)00050-X

doi: 10.1016/j.humpath.2009.11.020

Human Pathology
Volume 41, Issue 9 , Pages 1231-1237 , September 2010

Article Tools

* Image Usage & Resolution