Human Pathology
Volume 41, Issue 9 , Pages 1220-1230 , September 2010

Galectin-1 is a powerful marker to distinguish chondroblastic osteosarcoma and conventional chondrosarcoma

  • Anne Gomez-Brouchet, MD, PhD

      Affiliations

    • Service d'Anatomie Pathologique et Histologie-Cytologie, CHU Rangueil, 1 avenue du Prof. Jean-Poulhès TSA 50032, 31059 Toulouse cedex 9, France
    • Inserm U 858 I2MR, IRF 31, équipe 15, 1 avenue du Prof. Jean-Poulhès TSA 50032, 31059 Toulouse cedex 9, France
    • Corresponding Author InformationCorresponding author. Service d'Anatomie Pathologique et Histologie-Cytologie, CHU Rangueil, 1 avenue du Pr Jean-Poulhès TSA 50032, 31059 Toulouse cedex 9, France.
    • ,
  • Frédéric Mourcin, PhD

      Affiliations

    • Inserm UMR 631, CNRS UMR 6102, Université de la Méditerranée URM 6546, Centre d'Immunologie de Marseille Luminy, Case 906, 13288 Marseille cedex 9, France
    • ,
  • Pierre-Antoine Gourraud, PhD

      Affiliations

    • Laboratoire d'Epidémiologie et de Santé Publique, INSERM U558, Faculté de Médecine, 37, allées Jules Guesdes, 31073 Toulouse cedex, France
    • ,
  • Corinne Bouvier, MD, PhD

      Affiliations

    • Service d'Anatomie Pathologique, Hôpital La Timone 289 rue Saint-Pierre, 13005 Marseille, France
    • ,
  • Gonzague De Pinieux, MD, PhD

      Affiliations

    • Service d'Anatomie Pathologique, Hôpital Trousseau, avenue de la République, 37044 Tours cedex 9, France
    • ,
  • Sophie Le Guelec, MD

      Affiliations

    • Service d'Anatomie Pathologique et Histologie-Cytologie, CHU Rangueil, 1 avenue du Prof. Jean-Poulhès TSA 50032, 31059 Toulouse cedex 9, France
    • ,
  • Pierre Brousset, MD, PhD

      Affiliations

    • Service d'Anatomie Pathologique, CHU Purpan, 1 place Baylac, TSA 40031, 31059 Toulouse cedex 9, France
    • ,
  • Marie-Bernadette Delisle, MD, PhD

      Affiliations

    • Service d'Anatomie Pathologique et Histologie-Cytologie, CHU Rangueil, 1 avenue du Prof. Jean-Poulhès TSA 50032, 31059 Toulouse cedex 9, France
    • Inserm U 858 I2MR, IRF 31, équipe 15, 1 avenue du Prof. Jean-Poulhès TSA 50032, 31059 Toulouse cedex 9, France
    • Contributed equally to this work.
    • ,
  • Claudine Schiff, PhD

      Affiliations

    • Inserm UMR 631, CNRS UMR 6102, Université de la Méditerranée URM 6546, Centre d'Immunologie de Marseille Luminy, Case 906, 13288 Marseille cedex 9, France
    • Contributed equally to this work.

Received 14 September 2009 ,Revised 6 October 2009 ,Accepted 17 October 2009.

References 

  1. Fletcher CDM, Unni KK, Mertens F. Pathology and genetics of soft tissue and bone. Lyon: IRC Press; 2002;
  2. Huvos AG, Rosen G, Marcove RC. Primary osteogenic sarcoma: pathologic aspects in 20 patients after treatment with chemotherapy en bloc resection, and prosthetic bone replacement. Arch Pathol Lab Med. 1977;101:14–18
  3. Rosen G, Caparros B, Huvos AG, et al. Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer. 1982;49:1221–1230
  4. Picci P. Osteosarcoma (osteogenic sarcoma). Orphanet J Rare Dis. 2007;2:6
  5. Koh JS, Chung JH, Lee SY, Lee JH. Chondrosarcoma of the proximal femur with myxoid degeneration mistaken for chondromyxoid fibroma in a young adult. A case report. Acta Cytol. 2001;45:254–258
  6. Gupta K, Radhika S, Vasishta RK. Chondrosarcoma of calcanaeum in a 12-year-old male patient: a case report. Diagn Cytopathol. 2004;31:399–401
  7. Mahesha V, Goyal R, Vaiphei K, Nada R, Gupta AK. Primary chondrosarcoma of ethmoid bone in a 6-year-old child. Ann Diagn Pathol. 2006;10:154–156
  8. Komori T. Regulation of osteoblast differentiation by transcription factors. J Cell Biochem. 2006;99:1233–1239
  9. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M. Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Int J Biochem Cell Biol. 2008;40:46–62
  10. Salas S, de Pinieux G, Gomez-Brouchet A, et al. Ezrin immunohistochemical expression in cartilaginous tumours: a useful tool for differential diagnosis between chondroblastic osteosarcoma and chondrosarcoma. Virchows Arch. 2009;454:81–87
  11. Drickamer K. Two distinct classes of carbohydrate-recognition domains in animal lectins. J Biol Chem. 1988;263:9557–9560
  12. Sharon N, Lis H. Lectins as cell recognition molecules. Science. 1989;246:227–234
  13. Bourne Y, Bolgiano B, Liao DI, et al. Crosslinking of mammalian lectin (galectin-1) by complex biantennary saccharides. Nat Struct Biol. 1994;1:863–870
  14. Sanford GL, Harris-Hooker S. Stimulation of vascular cell proliferation by beta-galactoside specific lectins. FASEB J. 1990;4:2912–2918
  15. Ellerhorst J, Nguyen T, Cooper DN, Lotan D, Lotan R. Differential expression of endogenous galectin-1 and galectin-3 in human prostate cancer cell lines and effects of overexpressing galectin-1 on cell phenotype. Int J Oncol. 1999;14:217–224
  16. Rorive S, Belot N, Decaestecker C, et al. Galectin-1 is highly expressed in human gliomas with relevance for modulation of invasion of tumor astrocytes into the brain parenchyma. Glia. 2001;33:241–255[Erratum in: Glia 2001 Aug;35(2):166]
  17. Koh HS, Lee C, Lee KS, et al. CD7 expression and galectin-1-induced apoptosis of immature thymocytes are directly regulated by NF-kappaB upon T-cell activation. Biochem Biophys Res Commun. 2008;370:149–153
  18. Brandt B, Büchse T, Abou-Eladab EF, et al. Galectin-1 induced activation of the apoptotic death-receptor pathway in human Jurkat T lymphocytes. Histochem Cell Biol. 2008;129:599–609
  19. Valenzuela HF, Pace KE, Cabrera PV, et al. O-glycosylation regulates LNCaP prostate cancer cell susceptibility to apoptosis induced by galectin-1. Cancer Res. 2007;67:6155–6162
  20. Moiseeva EP, Spring EL, Baron JH, de Bono DP. Galectin 1 modulates attachment, spreading and migration of cultured vascular smooth muscle cells via interactions with cellular receptors and components of extracellular matrix. J Vasc Res. 1999;36:47–58
  21. Van den Brûle F, Califice S, Castronovo V. Expression of galectins in cancer: a critical review. Glycoconj J. 2004;19:537–542
  22. Camby I, Belot N, Lefranc F, et al. Galectin-1 modulates human glioblastoma cell migration into the brain through modifications to the actin cytoskeleton and levels of expression of small GTPases. J Neuropathol Exp Neurol. 2002;61:585–596
  23. Elola MT, Wolfenstein-Todel C, Troncoso MF, Vasta GR, Rabinovich GA. Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival. Cell Mol Life Sci. 2007;64:1679–1700
  24. Kopitz J, von Reitzenstein C, André S, et al. Negative regulation of neuroblastoma cell growth by carbohydrate-dependent surface binding of galectin-1 and functional divergence from galectin-3. J Biol Chem. 2001;276:35917–35923
  25. Andersen H, Jensen ON, Moiseeva EP, Eriksen EF. A proteome study of secreted prostatic factors affecting osteoblastic activity: galectin-1 is involved in differentiation of human bone marrow stromal cells. J Bone Miner Res. 2003;18:195–203
  26. Barondes SH, Castronovo V, Cooper DN, et al. Galectins: a family of animal beta-galactoside-binding lectins. Cell. 1994;76:597–598
  27. Camby I, Le Mercier M, Lefranc F, Kiss R. Galectin-1: a small protein with major functions. Glycobiology. 2006;16:137R–157R
  28. Thijssen VL, Postel R, Brandwijk RJ, et al. Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proc Natl Acad Sci U S A. 2006;103:15975–15980
  29. Satelli A, Rao PS, Gupta PK, Lockman PR, Srivenugopal KS, Rao US. Varied expression and localization of multiple galectins in different cancer cell lines. Oncol Rep. 2008;19:587–594
  30. Cindolo L, Benvenuto G, Salvatore P, et al. Galectin-1 and galectin-3 expression in human bladder transitional-cell carcinomas. Int J Cancer. 1999;84:39–43
  31. Chiariotti L, Berlingieri MT, Battaglia C, et al. Expression of galectin-1 in normal human thyroid gland and in differentiated and poorly differentiated thyroid tumors. Int J Cancer. 1995;64:171–175
  32. Xu XC, el-Naggar AK, Lotan R. Differential expression of galectin-1 and galectin-3 in thyroid tumors. Potential diagnostic implications. Am J Pathol. 1995;147:815–822
  33. Jung EJ, Moon HG, Cho BI, et al. Galectin-1 expression in cancer-associated stromal cells correlates tumor invasiveness and tumor progression in breast cancer. Int J Cancer. 2007;120:2331–2338
  34. Kononen J, Bubendorf L, Kallioniemi A, et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med. 1998;4:844–847
  35. Rossi B, Espeli M, Schiff C, Gauthier L. Clustering of pre-B cell integrins induces galectin-1 dependent pre-B cell receptor relocalization and activation. J Immunol. 2006;177:796–803
  36. Ludbrook J. Statistical techniques for comparing measurers and methods of measurement: a critical review. Clin Exp Pharmacol Physiol. 2002;29:527–536
  37. Malpica A, Matisic JP, Niekirk DV, et al. Kappa statistics to measure interrater and intrarater agreement for 1790 cervical biopsy specimens among twelve pathologists: qualitative histopathologic analysis and methodologic issues. Gynecol Oncol. 2005;99(3 Suppl 1):S38–S52

☆ This work was supported by the CNRS (Centre National de la Recherche Scientifique), INSERM (Institut National de la Santé et de la Recherche Médicale), and ANR (Agence Nationale de la Recherche; contract ANR-05-BLAN-3501).

PII: S0046-8177(10)00056-0

doi: 10.1016/j.humpath.2009.10.028

Human Pathology
Volume 41, Issue 9 , Pages 1220-1230 , September 2010

Article Tools

* Image Usage & Resolution