Human Pathology
Volume 41, Issue 10 , Pages 1438-1447, October 2010

Expression of Sox2 in human cervical carcinogenesis☆

  • Jing Ji, PhD

      Affiliations

    • Department of Reproductive Medicine, the First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an 710061, The People's Republic of China
    • ,
  • Peng-Sheng Zheng, MD, PhD

      Affiliations

    • Department of Reproductive Medicine, the First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an 710061, The People's Republic of China
    • Section of Cancer Stem Cell Research, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education of People's Republic of China, Xi'an 710061, The People's Republic of China
    • Corresponding Author InformationCorresponding author. Department of Reproductive Medicine, the First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an 710061, The People's Republic of China.

Received 27 August 2009; received in revised form 12 November 2009; accepted 20 November 2009. published online 16 August 2010.

Summary 

Sox2 is a key transcription factor for embryonic development and plays a critical role in determining the fate of stem cells. Recently, Sox2 has been detected in several human tumors, indicating a potential function in tumorigenesis. We initially reported remarkably increased nuclear Sox2 staining in cervical carcinomas compared with normal cervix (P < .05). Furthermore, Sox2 staining was detected in most tumorsphere cells isolated from fresh cervical cancer tissues but not among the differentiated tumorsphere cells. When Sox2 was stably expressed in cervical cancer cells (SiHa and HeLa), Sox2-overexpressing cells had increased proliferation, clonogenicity, and tumorigenicity in vitro and in vivo than control cells. These results suggest that Sox2 may participate in carcinogenesis of cervical carcinomas and may be a potential therapeutic target molecule for cervical cancers.

Keywords: Cervical cancer, Sox2, Cancer stem cells, Carcinogenesis

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☆ This research was supported by the National Natural Science Foundation of China (30571951/C1702; 30725043/C1702).

PII: S0046-8177(10)00113-9

doi:10.1016/j.humpath.2009.11.021

Human Pathology
Volume 41, Issue 10 , Pages 1438-1447, October 2010

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